2001
DOI: 10.1073/pnas.241516998
|View full text |Cite
|
Sign up to set email alerts
|

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D 3

Abstract: Steroids destined for intracellular metabolic conversion or binding to nuclear receptors are believed to cross cell membranes by passive diffusion. According to this free hormone hypothesis, steroids bound to plasma carrier proteins are inactive because they cannot reach their intracellular targets (1). However, recent data show that carrier proteins may greatly facilitate steroid uptake by endocytosis of steroid-carrier complexes followed by intracellular release of the steroid (2, 3). Megalin, a member of th… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

8
251
1
12

Year Published

2002
2002
2021
2021

Publication Types

Select...
8
1

Relationship

2
7

Authors

Journals

citations
Cited by 300 publications
(272 citation statements)
references
References 24 publications
8
251
1
12
Order By: Relevance
“…It should also be noted that in serum in vivo, as much as 99% of 25(OH)D 3 is bound to the vitamin D binding protein (DBP), and cellular uptake of this complex in the kidney via receptormediated endocytosis is essential for vitamin D homeostasis in vivo [40,41]. Vitamin D is transduced by two separate routes of uptake; active uptake in the presence of DBP and passive uptake in the absence of DBP.…”
Section: Discussionmentioning
confidence: 99%
“…It should also be noted that in serum in vivo, as much as 99% of 25(OH)D 3 is bound to the vitamin D binding protein (DBP), and cellular uptake of this complex in the kidney via receptormediated endocytosis is essential for vitamin D homeostasis in vivo [40,41]. Vitamin D is transduced by two separate routes of uptake; active uptake in the presence of DBP and passive uptake in the absence of DBP.…”
Section: Discussionmentioning
confidence: 99%
“…Analysis of the interaction between clusterin and apoER2 was performed as described for other receptor ligands (17,18).…”
Section: Methodsmentioning
confidence: 99%
“…L'internalisation de ces complexes fait intervenir au moins un co-récepteur, la mégaline. Cette conclusion repose sur l'interaction démontrée entre cubiline et mégaline et la co-localisation étroite des deux récepteurs [6], l'effet inhibiteur des anticorps anti-mégaline sur l'internalisation de la plupart des ligands, et l'absence d'internalisation des complexes ligand-cubiline chez les souris mégaline -/- [13][14][15][16]. Le rôle physiologique de la cubiline varie en fonction du site d'expression considéré.…”
Section: Ligands Et Fonctions De La Cubilineunclassified