Cubosomes as an emerging platform for drug delivery: a review of the state of the art

Abourehab, Mohammed A.S.; Ansari, Mohammad Javed; Singh, Anshul; Hassan, Ahmed; Abdelgawad, Mohamed A.; Shrivastav, Prachi; Abualsoud, Bassam M.; Amaral, Larissa Souza; Pramanik, Sheersha

doi:10.1039/d2tb00031h

Cited by 61 publications

(28 citation statements)

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“…Over the last decade, significant effort has been focused on designing and developing extremely efficient delivery systems that release active substances selectively and in a regulated manner. [146][147][148][149] Nonetheless, due to the inadequate solubility of drugs, 150,151 weak drug adsorptive capability, and complex drugrelease settings (e.g., gastric and intestinal environments), 152 attaining the long-term release of the drugs remains difficult. 153,154 Accordingly, BC-based scaffolds have potential drug delivery applications that can overcome many of the limitations of traditional drug delivery systems.…”

Section: Recent Advances On Bacterial Cellulose For the Delivery Of A...mentioning

confidence: 99%

Bacterial cellulose as a potential biopolymer in biomedical applications: a state-of-the-art review

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Section: Recent Advances On Bacterial Cellulose For the Delivery Of A...mentioning

confidence: 99%

Bacterial cellulose as a potential biopolymer in biomedical applications: a state-of-the-art review

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“…Moreover, several studies reported a half maximal inhibitory concentration (IC50) value of monoolein-based cubosomes in the range of 30-100 µg/mL [56,[59][60][61]. Cubosomes are licensed and marketed as a non-parenteral medication in the United Kingdom and are on the US FDA's list of inactive ingredient guidelines [20,62].…”

Section: Principal Constituentsmentioning

confidence: 99%

A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

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The impact of nanotechnology on the exponential growth of several research areas, particularly nanomedicine, is undeniable. The ability to deliver active molecules to the desired site could significantly improve the efficiency of medical treatments. One of the nanocarriers developed which has drawn researchers’ attention are cubosomes, which are nanosized dispersions of lipid bicontinuous cubic phases in water, consisting of a lipidic interior and aqueous domains folded in a cubic lattice. They stand out due to their ability to incorporate hydrophobic, hydrophilic, and amphiphilic compounds, their tortuous internal configuration that provides a sustained release, and the capacity to protect and safely deliver molecules. Several approaches can be taken to prepare this structure, as well as different lipids like monoolein or phytantriol. This review paper describes the different methods to prepare nanocarriers. As it is known, the physicochemical properties of nanocarriers are very important, as they influence their pharmacokinetics and their ability to incorporate and deliver active molecules. Therefore, an extensive characterization is essential to obtain the desired effect. As a result, we have extensively described the most common techniques to characterize cubosomes, particularly nanocarriers. The exceptional properties of the cubosomes make them suitable to be used in several applications in the biomedical field, from cancer therapeutics to imaging, which will be described. Taking in consideration the outstanding properties of cubosomes, their application in several research fields is envisaged.

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“…; to the polymeric chain. However, drug delivery using hydrogels has not been free of obstacles, but continuous advancements are helping to settle on a hydrogel design competently conformed to specific drug delivery [ 10 , 11 ]. Due to several limitations of using natural hydrophilic polymers in hydrogel preparation, e.g., low thermal stability [ 12 ], absorption capacity [ 13 ], gel strength [ 3 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

Ansari

Rajendran

Mohanto

et al. 2022

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A prominent research topic in contemporary advanced functional materials science is the production of smart materials based on polymers that may independently adjust their physical and/or chemical characteristics when subjected to external stimuli. Smart hydrogels based on poly(N-isopropylacrylamide) (PNIPAM) demonstrate distinct thermoresponsive features close to a lower critical solution temperature (LCST) that enhance their capability in various biomedical applications such as drug delivery, tissue engineering, and wound dressings. Nevertheless, they have intrinsic shortcomings such as poor mechanical properties, limited loading capacity of actives, and poor biodegradability. Formulation of PNIPAM with diverse functional constituents to develop hydrogel composites is an efficient scheme to overcome these defects, which can significantly help for practicable application. This review reports on the latest developments in functional PNIPAM-based smart hydrogels for various biomedical applications. The first section describes the properties of PNIPAM-based hydrogels, followed by potential applications in diverse fields. Ultimately, this review summarizes the challenges and opportunities in this emerging area of research and development concerning this fascinating polymer-based system deep-rooted in chemistry and material science.

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Cubosomes as an emerging platform for drug delivery: a review of the state of the art

Abstract: Lipid-based drug delivery nanoparticles, including non-lamellar type, mesophasic nanostructured materials of lyotropic liquid crystals (LLCs), have been a topic of interest for researchers for their applications in encapsulation of drugs...

Cited by 61 publications

References 230 publications

Bacterial cellulose as a potential biopolymer in biomedical applications: a state-of-the-art review

Bacterial cellulose as a potential biopolymer in biomedical applications: a state-of-the-art review

A Versatile Nanocarrier—Cubosomes, Characterization, and Applications

Poly(N-isopropylacrylamide)-Based Hydrogels for Biomedical Applications: A Review of the State-of-the-Art

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