Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats

This study demonstrated the therapeutic potentials of Cucumeropsis mannii seed oil (CMSO) capable of alleviating BPA‐induced dyslipidemia and adipokine dysfunction. In this study, we evaluated the effects of CMSO on adipokine dysfunctions and dyslipidemia in bisphenol‐A (BPA)‐induced male Wistar rats. Six‐week‐old 36 albino rats of 100–200 g weight were assigned randomly to six groups, which received varied doses of BPA and/or CMSO. The administration of BPA and CMSO was done at the same time for 42 days by oral intubation. The adipokine levels and lipid profile were measured in adipose tissue and plasma using standard methods. BPA induced significant (p < .05) increases in triglycerides, cholesterol, leptin, LDL‐C, and atherogenic and coronary risk indices in adipose tissue and plasma, as well as a decrease in adiponectin and HDL‐C levels in Group II animals. BPA administration significantly (p < .05) elevated Leptin levels and reduced adiponectin levels. BPA plus CMSO reduced triglycerides, cholesterol, leptin, LDL‐C, and atherogenic and coronary risk indices while increasing adiponectin levels and HDL‐C in adipose tissue and plasma (p < .05). The results showed that BPA exposure increased adipose tissue as well as serum levels of the atherogenic index, triglycerides, cholesterol, coronary risk index, LDL‐C, leptin, and body weight with decreased adiponectin levels and HDL‐C. Treatment with CMSO reduced the toxicities caused by BPA in rats by modulating the body weight, adiponectin/leptin levels, and lipid profiles in serum and adipose tissue. This study has shown that CMSO ameliorates BPA‐induced dyslipidemia and adipokine dysfunctions. We suggest for further clinical trial to establish the clinical applications.

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“…CMSO was extracted by applying the traditional and mechanical methods of Kate et al (2014) and modified by Agu et al (2022).…”

Section: Cmso Extractionmentioning

confidence: 99%

Cucumeropsis mannii seed oil ameliorates Bisphenol‐A‐induced adipokines dysfunctions and dyslipidemia

Aja

Chiadikaobi

Agu

et al. 2023

Food Science & Nutrition

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“…Cucumeropsis mannii is indigenous to tropical Africa, especially in the West of the Great Rift Valley. It is cultivated for food and as a source of oil in this tropical region (Agu et al, 2022 ). In addition to being known as white‐seed melon and Mann's cucumeropsis in English, it is also known as ahu‐ilu in Igbo, agushi in Hausa, and elegushi in Yoruba (Koffi et al, 2008 ) in Nigeria.…”

Section: Introductionmentioning

confidence: 99%

“…The fruits and seeds can both be consumed and also employed for various industrial processes and products (Okwundu et al, 2021 ). In west African countries, various parts of the C. mannii plants have been utilized (Agu et al, 2022 ; Okwundu et al, 2021 ). Ghanaians use the juice from the flesh fruit concocted with various condiments and apply to navel of newly born infants to fast‐track the curing progression till cord vestiges drip off; equally, in Gabon, steeped leaves have been in use as a purgative to constipated suckling babies (Agu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…In west African countries, various parts of the C. mannii plants have been utilized (Agu et al, 2022 ; Okwundu et al, 2021 ). Ghanaians use the juice from the flesh fruit concocted with various condiments and apply to navel of newly born infants to fast‐track the curing progression till cord vestiges drip off; equally, in Gabon, steeped leaves have been in use as a purgative to constipated suckling babies (Agu et al, 2022 ). The Sierra Leonian cattle boys conventionally make use of the desiccated C. manni fruit shell as a horn warner (Awuchi, 2023 ; Leakey et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…The characteristic phytochemical constituents reported present in C. mannii seed and its oil according to Badifu and Ogunsua ( 1990 ) were alkaloids, phenols, flavonoids, terpenes, and tannin, which are exogenous antioxidants. Agu et al ( 2022 ) reported that Cucumeropsis mannii seed oil (CMSO) reversed altered testicular histology/biochemistry in male rats against toxicity induced by BPA. We considered that there is no limit to the exploration of plants' therapeutic potentials (Aja et al, 2014 ) and adopted the use of animal model to further enlist C. mannii seed oil potentials as an emerging therapeutic natural product.…”

Section: Introductionmentioning

confidence: 99%

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Cucumeropsis mannii seed oil protects against Bisphenol A‐induced testicular mitochondrial damages

Aja

Ogwoni

Agu

et al. 2023

Food Science & Nutrition

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There has been increasing search for the ameliorative properties of seed oils against toxicants. bisphenol A acts as an estrogenic endocrine‐disrupting chemical capable of causing male infertility. This study aimed to explore Cucumeropsis mannii seed oil effects against mitochondrial damage in rats using bisphenol A. Forty‐eight rats were randomly assigned to six groups (n = 6) of eight rats each and fed the same food and water for 6 weeks. The group A rats were given 1 mL olive oil, while the ones in group B were given bisphenol A at 100 mL/kg body weight via oral route. Group C received C. mannii seed oil 7.5 mL/kg body weight C. mannii seed oil, while group D, group E, and group F were pre‐administered bisphenol A at 100 mL/kg body weight, followed by treatment with C. mannii seed oil at 7.5, 5, and 2.5 mL/kg body weight, respectively. Antioxidant enzymes, glutathione, reactive oxygen species, testicular volume, malondialdehyde, body weight, and testicular studies were done using standard methods. The results of the bisphenol A‐administered group showed a significant decrease in the antioxidant enzymes, glutathione, body weight, and testicular volume with elevation in the levels of reactive oxygen species, malondialdehyde, and testicular indices. BPA + CMSO‐treated group showed a significant increase in GPx activity compared with BPA‐exposed rats. CMSO treatment significantly increased catalase activity in comparison with that of rats exposed to BPA. Remarkably, C. mannii seed oil and bisphenol A co‐administration significantly reversed the abnormalities observed in the dysregulated biochemical biomarkers. Our findings suggest that C. mannii seed oil has considerable antioxidant potential which can be explored in therapeutic development against systemic toxicity induced by exposure to bisphenol A. Cucumeropsis mannii seed oil protects against bisphenol A‐induced testicular mitochondria damages.

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Cucumeropsis mannii seed oil (CMSO) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A

Ogwoni,

Aja,

Eze

et al. 2024

Food Science & Nutrition

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Bisphenol A, a traditional endocrine disruptor, has been implicated in male infertility. This study investigated the effect of Cucumeropsis mannii seed oil (CMSO) on bisphenol A (BPA)‐induced biochemical toxicity in the testicular mitochondria of male albino rats. The rats were assigned randomly to six experimental groups (n = 6), A, B, C, D, E, and F. Group A received 1 mL of olive oil. Groups B and C received 100 mL/kg body weight (BW) of BPA and 7.5 mL/kg BW CMSO, respectively. Rats in groups D, E, and F received preadministered doses of 100 mL/kg BW of BPA, 5 mL/kg BW of BPA, and 2.5 mL/kg BW of CMSO, respectively, followed by 6 weeks of exposure to those doses. Some mitochondrial enzymes, mitochondrial membrane potential (MMP), mitochondria testicular protein, and body weight of rats were determined using standard methods. BPA significantly reduced succinate dehydrogenase, malate dehydrogenase, isocitrate dehydrogenase, NADH dehydrogenase, and monoamine oxidase activity. Also, BPA prominently decreased the MMP, mitochondrial testicular protein, and body weight of rats. Interestingly, coadministration of BPA and CMSO restored the dysregulated activities of the enzymes and levels of other biomarkers. We postulated that CMSO may be a promising drug for treating systemic toxicity caused by environmental toxicants such as BPA.

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Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats

Cited by 17 publications

References 63 publications

Cucumeropsis mannii seed oil ameliorates Bisphenol‐A‐induced adipokines dysfunctions and dyslipidemia

Cucumeropsis mannii seed oil ameliorates Bisphenol‐A‐induced adipokines dysfunctions and dyslipidemia

Cucumeropsis mannii seed oil protects against Bisphenol A‐induced testicular mitochondrial damages

Cucumeropsis mannii seed oil (CMSO) restores testicular mitochondrial dysfunctions by modulating the activities of dysregulated testicular mitochondrial enzymes in male albino rats exposed to bisphenol A

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