Cucurbitacin E ameliorates lipopolysaccharide-evoked injury, inflammation and MUC5AC expression in bronchial epithelial cells by restraining the HMGB1-TLR4-NF-κB signaling

Shang, Jin; Liu, Weihua; Chen, Yin; Chu, Haiping; Zhang, Meizhen

doi:10.1016/j.molimm.2019.09.008

Cited by 52 publications

(37 citation statements)

References 27 publications

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“…Comp 1 also suppressed the production of TNF-α and IL-6, and the activation of NF-κB and ERK1/2 by HMGB1 [133] Cucurbitacin E (CuE), a tetracyclic triterpene isolated from Cucurbitaceae plants, has proven to exert anti-inflammatory and immunologically regulatory activities. Recent findings highlight that CuE can ameliorate human bronchial epithelial cell insult and inflammation under LPS-stimulated asthmatic conditions by blocking the HMGB1-TLR4-NF-κB signaling [134].…”

Section: Abronia Nana S Watsonmentioning

confidence: 99%

Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review

Wyganowska‐Świątkowska¹,

Nohawica²,

Grocholewicz

et al. 2020

IJMS

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By attaching to the angiotensin converting enzyme 2 (ACE2) protein on lung and intestinal cells, Sudden Acute Respiratory Syndrome (SARS-CoV-2) can cause respiratory and homeostatic difficulties leading to sepsis. The progression from acute respiratory failure to sepsis has been correlated with the release of high-mobility group box 1 protein (HMGB1). Lack of effective conventional treatment of this septic state has spiked an interest in alternative medicine. This review of herbal extracts has identified multiple candidates which can target the release of HMGB1 and potentially reduce mortality by preventing progression from respiratory distress to sepsis. Some of the identified mixtures have also been shown to interfere with viral attachment. Due to the wide variability in chemical superstructure of the components of assorted herbal extracts, common motifs have been identified. Looking at the most active compounds in each extract it becomes evident that as a group, phenolic compounds have a broad enzyme inhibiting function. They have been shown to act against the priming of SARS-CoV-2 attachment proteins by host and viral enzymes, and the release of HMGB1 by host immune cells. An argument for the value in a nonspecific inhibitory action has been drawn. Hopefully these findings can drive future drug development and clinical procedures.

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Section: Abronia Nana S Watsonmentioning

confidence: 99%

Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review

Wyganowska‐Świątkowska¹,

Nohawica²,

Grocholewicz

et al. 2020

IJMS

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“…Finally, severe asthmatics with mucus hypersecretion may benefit from non-pharmacological treatment approaches such as bronchial thermoplasty [17], but the evidence to date needs confirmation. Due to the lack of effective treatments, a remarkable amount of research has been lately employed to identify possible potent MUC5AC inhibitory agents among natural compounds, such as flavonoids, glycoside, and steroid-like molecules, that demonstrated modulatory effects on mucin expression, secretion, and production [18,19]. Some line of evidence previously suggested that Pseudomonas aeruginosa , a microorganism frequently responsible for acute and chronic lung infections in patients with COPD or bronchiectasis, activates mucus hypersecretion and MUC5AC expression through the EGF receptor pathway [20].…”

mentioning

confidence: 99%

Mucins and Asthma: Are We Headed to the Revolutionary Road?

Santus

Radovanovic

Chiumello

2019

JCM

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Mucus represents the first line of defense of our respiratory tract and mucociliary clearance is essential for maintaining the homeostasis of airway epithelium. The latter mechanisms are altered in asthma and mucus plugging of proximal and distal airways is the main cause of death in cases of fatal asthma. Starting from the influential review performed by Luke R. Bonser and David J. Erle in 2017, we discuss the latest evidence in terms of mucins regulation and potential treatment of mucus hypersecretion and tissue remodeling in severe asthma.

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“…NF-jB acts as an important inflammatory pathway to regulate inflammation [37]. NKILA expression is activated by NF-jB pathway and directly occluded by interacting with the NF-jB/IjB complex.…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA NKILA weakens TNF-α-induced inflammation of MRC-5 cells by miR-21 up-regulation

Wang

Zhang

Sun

et al. 2020

Artificial Cells, Nanomedicine, and Biotechnology

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Background: Infantile pneumonia (IP) seriously affects the health of children. This article mainly discussed the protective effect of long non-coding RNA NKILA (lnc NKILA) on IP by detecting cell viability, apoptosis and inflammatory response of MRC5 cells. Methods: Cell counting kit-8 (CCK-8) was used to detect cell viability, while flow cytometry was used to detect cell apoptosis. The expression of apoptosis-associated factors (Bcl-2, Bax, PARP and Cleaved-PARP) and NF-jB and JNK pathway-related factors (t-IjBa, p-IjBa, t-p65, p-p65, b-actin, t-JNK and p-JNK) were tested by western blot. Otherwise, productions of inflammatory factors interleukin (IL)-1b and IL-6 were tested by enzyme-linked immunosorbent assay (ELISA) and western blot. Furthermore, RNA levels were respectively tested and changed by RT-qPCR and cell transfection. Results: Tumour necrosis factor-a (TNF-a) treatment reduced cell viability, induced cell apoptosis and promoted inflammatory factors expression. NKILA overexpression remitted TNF-a-induced injury. Moreover, NKILA positively regulated miR-21. miR-21 inhibition could weaken the functions of NKILA overexpression on TNF-a-induced injury. At last, NKILA and miR-21 were involved in the regulation of JNK and NF-jB pathways. Conclusions: NKILA overexpression remitted TNF-a-induced MRC5 cell injury by up-regulation of miR-21 and via inactivation of JNK and NF-jB signaling pathways. ARTICLE HISTORY

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Cucurbitacin E ameliorates lipopolysaccharide-evoked injury, inflammation and MUC5AC expression in bronchial epithelial cells by restraining the HMGB1-TLR4-NF-κB signaling

Cited by 52 publications

References 27 publications

Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review

Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review

Mucins and Asthma: Are We Headed to the Revolutionary Road?

Long non-coding RNA NKILA weakens TNF-α-induced inflammation of MRC-5 cells by miR-21 up-regulation

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