Cucurbitane triterpenoids from Hemsleya penxianensis

Abstract

Two new cucurbitacins, jinfushanencins A (1) and B (2), seven new cucurbitane glycosides, jinfushanosides EK (39), along with nine known analogues, were obtained from the tubers of Hemsleya penxianensis. Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Selected isolates were tested their anti-HIV-1 activities, and compound 5 showed weak anti-HIV-1 in C8166 cell (EC 50 = 5.9 μg/mL) with a selectivity index of 13.5.

Identification of 16,25- O -diacetyl-cucurbitane F and 25- O -acetyl-23,24-dihydrocucurbitacin F as novel anti-cancer chemicals

“…In this paper, we elucidated the isolation and structure of seven new saponins. Moreover, based on our research results and previous published data [4][5][6][7][8], the relationships between the nuclear magnetic resonance (NMR) characteristics and the common substituents of cucurbitane tetracyclic triterpenes were discussed.…”