Cucurbitane‐type triterpene glycosides from the fruits of <i>Momordica charantia</i>

Nguyen, Xuan Nhiem; Phan, Van Kiem; Chau, Van Minh; Ninh, Khac Ban; Nguyen, Xuan Cuong; Le, Minh Ha; Bui, Huu Tai; Tran, Hong Quang; Nguyen, Huu Tung; Kim, Young Ho

doi:10.1002/mrc.2582

Cited by 27 publications

(26 citation statements)

References 19 publications

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“…Saponins are a group of high molecularweight compounds in which the saccharide units of glycosides were linked with triterpene groups. charantosides (I-VIII), momordicosides U, V, and W were some of the major saponins identified from M. charantia fruits [38,39]. Other types of saponins like goyasaponins I, II and III have been reported in the fresh fruit of Japanese M. charantia [40].…”

Section: Cucurbitane Type Triterpenoidsmentioning

confidence: 97%

Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review

Nagarani

Abirami

Siddhuraju

2014

Food Science and Human Wellness

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Plants with potential therapeutic values have been used from time immemorial to cure various ailments and infectious diseases. Of late, scientific evidences have been provided on the potential therapeutic agent exhibited by certain traditionally used vegetable extracts. The importance of wild edible plants may be traced to antiquity but systemic studies are recent. All the Momordica species have been consumed as vegetable and traditionally used for various disorders. The whole plant parts are ascribed to possess the anti-diabetic effect in traditional medicinal system. The active constituents of Momordica plant parts were cucurbitane type triterpenoids, phenolics, glycosides, and several kinds of peptides including Momordica anti-HIV protein (MAP 30). Recent reports revealed the presence of several kinds of cucurbitane type triterpenoids in leaf, stem and fruits of Momordica species having several pharmacological activities. There is lack of scientific information available on the wild species which also having several bioactive components with potential activities. So the present review compares and highlights the current knowledge of the nutritional value, phytochemistry and physiological effects of wild species with known variety.

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Section: Cucurbitane Type Triterpenoidsmentioning

confidence: 97%

Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review

Nagarani

Abirami

Siddhuraju

2014

Food Science and Human Wellness

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“…Kuguaoside A produces potent anti-proliferative effects with IC 50 values being 12.60 ± 0.69, 19.37 ± 1.73, 15.89 ± 1.39, and 17.42 ± 0.79 μg·mL −1 , respectively [66] . Momordicoside A–E, F, F1, G, I, and K–W [67, 70–73] have been isolated and purified from MC. Momordicoside F1, F2, I, K, U ( 27–31 ) exert anti-proliferative effects against human cancer MCF-7, WiDr, HEp-2, and Doay cells [66] .…”

Section: Introductionmentioning

confidence: 99%

Bitter melon: a panacea for inflammation and cancer

Dandawate

Subramaniam

Padhyé³

et al. 2016

Chinese Journal of Natural Medicines

115

123

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Nature is a rich source of medicinal plants and their products that are useful for treatment of various diseases and disorders. Momordica charantia, commonly known as bitter melon or bitter gourd, is one of such plants known for its biological activities used in traditional system of medicines. This plant is cultivated in all over the world, including tropical areas of Asia, Amazon, east Africa, and the Caribbean and used as a vegetable as well as folk medicine. All parts of the plant, including the fruit, are commonly consumed and cooked with different vegetables, stir-fried, stuffed or used in small quantities in soups or beans to give a slightly bitter flavor and taste. The plant is reported to possess anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-obesity, and immunomodulatory activities. The plant extract inhibits cancer cell growth by inducing apoptosis, cell cycle arrest, autophagy and inhibiting cancer stem cells. The plant is rich in bioactive chemical constituents like cucurbitane type triterpenoids, triterpene glycosides, phenolic acids, flavonoids, essential oils, saponins, fatty acids, and proteins. Some of the isolated compounds (Kuguacin J, Karaviloside XI, Kuguaglycoside C, Momordicoside Q–U, Charantin, α-eleostearic acid) and proteins (α-Momorcharin, RNase MC2, MAP30) possess potent biological activity. In the present review, we are summarizing the anti-oxidant, anti-inflammatory, and anti-cancer activities of Momordica charantia along with a short account of important chemical constituents, providing a basis for establishing detail biological activities of the plant and developing novel drug molecules based on the active chemical constituents.

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“…The molecules were identified as 3-O-β-gentiobioside and 3-O-β-D-xylopyranosyl(1→4)[β-D-glucopyranosyl(1→6)]-β-D-glucopyranoside of cucurbit-5-ene-3β, 22(S), 23(R), 24(R), 25-pentol. In subsequent publications, an additional twenty-one momordicosides (C-X) were identified from fruits, seeds, vines, and roots of the bitter melon plant (21,22,43,54,56,(62)(63)(64)(65)(66). Similarly, several other triterpenoids have been identified and named from the bitter melon plant, including momordicine (I-VIII), (58,60,(67)(68)(69)(70)(71), goyaglycosides (A-H) and goyasaponins (I-III) (36), karavilagenin (A-F) and karavilosides (I-XII) (37,59,72), charantosides (I-VIII, and A-G) (30,42,73,74), kuguacin (A-S) (27,44) (78).…”

Section: Reported Ctmsmentioning

confidence: 99%