Cue Reactivity in Nicotine and Alcohol Addiction: A Cross-Cultural View

Lv, Wanwan; Wu, Qichao; Liu, Xiaoming; Chen, Ying; Song, Hongwen; Yang, Lizhuang; Zhang, Xiaochu

doi:10.3389/fpsyg.2016.01335

Cited by 53 publications

(8 citation statements)

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“…Our recent study that used resting state functional magnetic resonance imaging (rsfMRI) to study love-related changes in resting state functional connectivity provided some new and important evidences for romantic love related functional alterations in brain network (Song et al, 2015 ). Combined our previous studies about romantic love (Wang et al, 2016 ) and addiction (Zhang et al, 2009 , 2011 ; Lv et al, 2016 ; Wei et al, 2016 ), we found that romantic love and addiction have the significant differences in resting-state brain network. Therefore, systematic comparison between romantic love and addiction may be helpful to understand the similarities and differences of them, and may inspire a new possible treatment to addiction.…”

Section: Introductionsupporting

confidence: 77%

Romantic Love vs. Drug Addiction May Inspire a New Treatment for Addiction

et al. 2016

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Drug addiction is a complex neurological dysfunction induced by recurring drug intoxication. Strategies to prevent and treat drug addiction constitute a topic of research interest. Early-stage romantic love is characterized by some characteristics of addiction, which gradually disappear as the love relationship progresses. Therefore, comparison of the concordance and discordance between romantic love and drug addiction may elucidate potential treatments for addiction. This focused review uses the evidences from our recent studies to compare the neural alterations between romantic love and drug addiction, moreover we also compare the behavioral and neurochemical alterations between romantic love and drug addiction. From the behavioral comparisons we find that there are many similarities between the early stage of romantic love and drug addiction, and this stage romantic love is considered as a behavioral addiction, while significant differences exist between the later stage of romantic love and drug addiction, and this stage of romantic love eventually developed into a prosocial behavior. The neuroimaging comparisons suggest that romantic love and drug addiction both display the functional enhancement in reward and emotion regulation network. Except the similar neural changes, romantic love display special function enhancement in social cognition network, while drug addiction display special dysfunction in cognitive control network. The neurochemical comparisons show that there are many similarities in the dopamine (DA) system, while significant differences in oxytocin (OT) system for romantic love and drug addiction. These findings indicate that the functional alterations in reward and emotion regulation network and the DA system may be the neurophysiological basis of romantic love as a behavioral addiction, and the functional alterations in social cognition network and the OT system may be the neurophysiological basis of romantic love as a prosocial behavior. It seems that the OT system is a critical factor for the development of addiction. So we then discuss strategies to treat drug addiction with OT, and suggest that future research should further investigate OT system interventions aiming to improve cognitive control and/or social cognition functions, in order to develop strategies designed to more effectively treat drug addiction.

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Section: Introductionsupporting

confidence: 77%

Romantic Love vs. Drug Addiction May Inspire a New Treatment for Addiction

et al. 2016

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“…Most of the studies focus their attentions on neuroimaging effects of alcohol cue exposure. 3 – 5 In this process, neuroimaging methods were widely used to demonstrate task-specific or cue-specific alterations in regional brain activity. However, it may hamper us to insights into integrated global brain function alterations in resting-state or non-task condition when we solely focus on regional functional brain activity alterations under task-specific or cue-specific conditions because of the behavioral variability.…”

Section: Introductionmentioning

confidence: 99%

Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis

Luo¹,

Guo²,

Dai³

et al. 2017

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ObjectiveTo explore the abnormal intrinsic functional hubs in alcohol dependence using voxelwise degree centrality analysis approach, and their relationships with clinical features.Materials and methodsTwenty-four male alcohol dependence subjects free of medicine (mean age, 50.21±9.62 years) and 24 age- and education-matched male healthy controls (mean age, 50.29±8.92 years) were recruited. The alcohol use disorders identification test and the severity of alcohol dependence questionnaire (SADQ) were administered to assess the severity of alcohol craving. Voxelwise degree centrality approach was used to assess the abnormal intrinsic functional hubs features in alcohol dependence. Simple linear regression analysis was performed to investigate the relationships between the clinical features and abnormal intrinsic functional hubs.ResultsCompared with healthy controls, alcohol dependence subjects exhibited significantly different degree centrality values in widespread left lateralization brain areas, including higher degree centrality values in the left precentral gyrus (BA 6), right hippocampus (BA 35, 36), and left orbitofrontal cortex (BA 11) and lower degree centrality values in the left cerebellum posterior lobe, bilateral secondary visual network (BA 18), and left precuneus (BA 7, 19). SADQ revealed a negative linear correlation with the degree centrality value in the left precentral gyrus (R2=0.296, P=0.006).ConclusionThe specific abnormal intrinsic functional hubs appear to be disrupted by alcohol intoxication, which implicates at least three principal neural systems: including cerebellar, executive control, and visual cortex, which may further affect the normal motor behavior such as an explicit type of impaired driving behavior. These findings expand our understanding of the functional characteristics of alcohol dependence and may provide a new insight into the understanding of the dysfunction and pathophysiology of alcohol dependence.

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“…Prior research has shown that co-use of alcohol and tobacco is associated with significantly greater demand for alcohol compared with use of alcohol alone, even after controlling for differences in drinking and demographics (Amlung et al 2017;Yu rasek et al 2013). This difference is hypothesized to result from several factors including cross-commodity craving and cue reactivity, as well as alcohol priming (Drobes, 2002;Lv et al, 2016;McKee et al, 2010).…”

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confidence: 99%

Elevated Behavioral Economic Demand for Alcohol in Co-Users of Alcohol and Cannabis

Morris

Patel

Vedelago

et al. 2018

J. Stud. Alcohol Drugs

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Co-use of cannabis and alcohol is associated with increased drinking and other negative consequences relative to use of alcohol alone. One potential explanation for these differences is overvaluation of alcohol (e.g., alcohol demand) among co-users, similar to established overvaluation of alcohol among tobacco and alcohol co-users. This study examined differences in alcohol demand between an alcohol and cannabis co-user group and an alcohol-only group. Method: A large sample of adult drinkers (n = 1,643, 54% female) was recruited through an online crowdsourcing site (Amazon Mechanical Turk). Of the full sample, 476 participants reported weekly or greater cannabis use in the past 6 months (co-user group); 888 reported never using cannabis in the past 6 months (alcohol-only group). Assessments included a validated alcohol purchase task and self-report measures of alcohol and cannabis use. Results: Co-users reported significantly higher alcohol consumption across the elastic portion of the alcohol demand curve (i.e., $1.50-$9.00/drink). Analyses of covariance controlling for alcohol use and demographics revealed significantly higher breakpoint (p = .025) and Omax (p = .002) and significantly lower elasticity (p < .003) in the co-user group. Intensity and Pmax did not significantly differ between groups. Conclusions: Co-users of cannabis and alcohol overvalue alcohol compared with individuals who drink alcohol but do not use cannabis. This study is generally consistent with prior studies on alcohol and tobacco co-users, providing converging evidence that polysubstance use is associated with overvaluation of alcohol. These fi ndings have important implications for treatment and prevention, particularly in the context of changes in cannabis legalization.

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Cue Reactivity in Nicotine and Alcohol Addiction: A Cross-Cultural View

Cited by 53 publications

References 100 publications

Romantic Love vs. Drug Addiction May Inspire a New Treatment for Addiction

Romantic Love vs. Drug Addiction May Inspire a New Treatment for Addiction

Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis

Elevated Behavioral Economic Demand for Alcohol in Co-Users of Alcohol and Cannabis

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