Cultivable microbiota and pulmonary lesions in polymicrobial bovine pneumonia

Choudhary, Mamta; Choudhary, B.K.; Ghosh, R. C.; Bhoyar, Smita; Chaudhari, S. P.; Barbuddhe, Sukhadeo B.

doi:10.1016/j.micpath.2019.103577

Cited by 13 publications

(7 citation statements)

References 48 publications

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“…High resistance was detected against chloramphenicol which disagreed with (Choudhary et al, 2019) who demonstrated that 100% of P. multocida isolates were responsive to chloramphenicol. (Vassort-Bruneau et al, 1996) reported that chloramphenicol resistance is typically attributed to plasmids that encode inactivating enzymes; the chloramphenicol acetyltransferases.…”

Section: P Multocidacontrasting

confidence: 69%

Multi-Drug Resistant Pasteurella multocida and Mannheimia haemolytica Strains Isolated from Different Hosts Affected by Pneumonic Pasteurellosis in Egypt

Bahr¹,

Salib²,

Soliman³

et al. 2020

AAVS

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Advances in Animal and Veterinary Sciencesor physiological stress induced by unfavourable climatic and ecological conditions, including severely bad weather, improper management, co-mingling, overcrowding, shipping or prior infection with mycoplasma, respiratory viruses or certain other pathogens, may therefore contribute to pneumonic pasteurellosis (Tadesse et al., 2017).The acute febrile course of pneumonic pasteurellosis is characterized by death of infected animals within few days after the onset of clinical signs if they are not properly

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Section: P Multocidacontrasting

confidence: 69%

Multi-Drug Resistant Pasteurella multocida and Mannheimia haemolytica Strains Isolated from Different Hosts Affected by Pneumonic Pasteurellosis in Egypt

Bahr¹,

Salib²,

Soliman³

et al. 2020

AAVS

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“…Heart may be severely congested and there may be presence of petechial as well as haemorrhagic streaks and necrotic foci which can be visible upon removal of pericardium ( Figure 5). Rounding of heart and haemorrhages were also observed by Kapoor et al [23]. The liver is one of the severely affected organs in this disease.…”

Section: Gross Pathological Lesionssupporting

confidence: 67%

“…Pleura and alveolar septa get thickened with fibrin, oedema and infiltration of polymorphonuclear cells. [23][24][25][26]. Haemorrhages and necrosis may be evident in heart.…”

Section: Histopathological Lesionsmentioning

confidence: 99%

Pathological Changes Associated with Natural Outbreak of Swine Pasteurellosis

Choudhary¹,

Choudhary²,

Ghosh³

2020

Pests, Weeds and Diseases in Agricultural Crop and Animal Husbandry Production

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Swine pasteurellosis is usually observed in descript as well as nondescript pigs imparting in huge economic losses to the pig producers. The disease is characterized by pyrexia, dullness, staggering gait, anorexia, serous nasal discharge and dyspnoea. Case fatality rate may as high as 95% in adult animals and 100% in piglets. Typical lesions of oedematous swellings may remarkably visible in the pharyngeal region, these swellings spread to the ventral cervical region and brisket of pigs. Gross lesions include severe pneumonia and haemorrhages in lungs, petechial haemorrhages on serous membranes and other visceral organs. Lymph nodes usually get enlarged, oedematous and haemorrhagic. The blood smears from heart blood and tissue impression smears reveal teaming numbers of bipolar organisms indicating the presence of Pasteurella spp., the etiological organism. The bacteriological isolation and characterization of causative agent should be ruled out to identify by Gram’ staining for purity and bipolar morphology and biochemical characterization of the organisms. Molecular characterization necessitates to confirm Pasteurella multocida along with capsular types of the organism. Histopathological examination of lungs usually reveals typical fibrinous bronchopneumonia, multifocal suppuration and pleural thickening. Heart of some pigs may show presence of thrombi, haemorrhages and necrosed myocardium.

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“…Moreover, it has been reported that bacteria including Staphylococcus aureus and Escherichia coli are common risk factors for pneumonia in FMD ( 11 , 12 , 17 , 68 ). Moreover, multiple bacterial pathogens, such as Leclercia spp., Stenotrophononas maltophila, Staphylococcus aureus , and Staphylococcus sciur , have been identified in bovine pneumonia ( 69 , 70 ). Thus, differentially expressed proteins in the pathways of Staphylococcus aureus infection, bacterial invasion of epithelial cells, and pathogenic Escherichia coli infection were screened out.…”

Section: Discussionmentioning

confidence: 99%

ITRAQ-based quantitative proteomics analysis of forest musk deer with pneumonia

Tang

Suo²,

Li³

et al. 2022

Front. Vet. Sci.

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Pneumonia can seriously threaten the life of forest musk deer (FMD, an endangered species). To gain a comprehensive understanding of pneumonia pathogenesis in FMD, iTRAQ-based proteomics analysis was performed in diseased (Pne group) lung tissues of FMD that died of pneumonia and normal lung tissues (Ctrl group) of FMD that died from fighting against each other. Results showed that 355 proteins were differentially expressed (fold change ≥ 1.2 and adjusted P-value < 0.05) in Pne vs. Ctrl. GO/KEGG annotation and enrichment analyses showed that dysregulated proteins might play vital roles in bacterial infection and immunity. Given the close association between bacterial infection and pneumonia, 32 dysregulated proteins related to Staphylococcus aureus infection, bacterial invasion of epithelial cells, and pathogenic Escherichia coli infection were screened out. Among these 32 proteins, 13 proteins were mapped to the bovine genome. Given the close phylogenetic relationships of FMD and bovine, the protein-protein interaction networks of the above-mentioned 13 proteins were constructed by the String database. Based on the node degree analysis, 5 potential key proteins related to pneumonia-related bacterial infection in FMD were filtered out. Moreover, 85 dysregulated proteins related to the immune system process were identified given the tight connection between immune dysregulation and pneumonia pathogenesis. Additionally, 12 proteins that might function as crucial players in pneumonia-related immune response in FMD were screened out using the same experimental strategies described above. In conclusion, some vital proteins, biological processes, and pathways in pneumonia development were identified in FMD.

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Cultivable microbiota and pulmonary lesions in polymicrobial bovine pneumonia

Cited by 13 publications

References 48 publications

Multi-Drug Resistant Pasteurella multocida and Mannheimia haemolytica Strains Isolated from Different Hosts Affected by Pneumonic Pasteurellosis in Egypt

Multi-Drug Resistant Pasteurella multocida and Mannheimia haemolytica Strains Isolated from Different Hosts Affected by Pneumonic Pasteurellosis in Egypt

Pathological Changes Associated with Natural Outbreak of Swine Pasteurellosis

ITRAQ-based quantitative proteomics analysis of forest musk deer with pneumonia

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