Cultivation of Animal Cells in a New Modular Minifermenter

Weichert, Heiko; Falkenberg, Frank W.; Krane, M.; Behn, Ingrid; Hommel, U.; Nagels, H. O.

doi:10.1007/978-94-011-0437-1_145

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Culture Systems and Bioreactors Used In Tissue Engineering1

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“…In membrane bioreactors including hollow-fiber reactors (47), the miniPerm system (48) or the tecnomouse (49), cells are cultivated at tissuelike densities in a compartment, which contains one or several types of membrane for nutrient and oxygen supply and removal of toxic metabolites. Hollow-fiber systems are widely used in the production of biopharmaceuticals including monoclonal antibodies.…”

Section: Culture Systems and Bioreactors Used In Tissue Engineeringmentioning

confidence: 99%

Bioreactor design for tissue engineering

Pörtner

Nagel-Heyer

Goepfert

et al. 2005

Journal of Bioscience and Bioengineering

279

174

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Section: Culture Systems and Bioreactors Used In Tissue Engineeringmentioning

confidence: 99%

Bioreactor design for tissue engineering

Pörtner

Nagel-Heyer

Goepfert

et al. 2005

Journal of Bioscience and Bioengineering

279

174

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An Overview on Bioreactor Design, Prototyping and Process Control for Reproducible Three‐Dimensional Tissue Culture

Pörtner

Giese²

2006

Drug Testing in Vitro

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Bioreactor systems play an important role in tissue engineering, as they enable reproducible and controlled changes to be made in specifi c environmental factors. They can also provide the technical means to perform controlled studies aimed at understanding specifi c biological, chemical, or physical effects. Furthermore, bioreactors allow for a safe and reproducible production of tissue constructs. For later clinical applications, the bioreactor system should be an advantageous method in terms of low contamination risk, ease of handling, and scalability. With respect to drug screening, the main challenge is the effi cient, reproducible handling of a large quantity of tissue constructs in parallel (high-throughput screening). To date, the goals and expectations of bioreactor development have been fulfi lled only to some extent, as bioreactor design in tissue engineering is very complex and still at an early stage of development, especially for use in drug screening. In this chapter, important aspects of bioreactor design are summarized, and an overview of existing concepts is provided. An artifi cial immunosystem will be used as an example to demonstrate how an increased fundamental understanding of biological, biochemical, and engineering aspects can signifi cantly improve the properties of 3D tissue constructs.

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Cultivation of Animal Cells in a New Modular Minifermenter

Cited by 2 publications

References 1 publication

Bioreactor design for tissue engineering

Bioreactor design for tissue engineering

An Overview on Bioreactor Design, Prototyping and Process Control for Reproducible Three‐Dimensional Tissue Culture

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