Cultural Implications of Moghat (Glossostemon bruguieri) and Breastfeeding in Egypt: A Brief Narrative Review

Aboul‐Enein, Basil H.

doi:10.9730/ojccnh.org/v3n4a2

Cited by 1 publication

(1 citation statement)

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“…G. Bruguieri (moghat), family Sterculiaceae, grows wild in Iraq and Iran from where it was imported and introduced to Egypt in 1932 [24]. It is considered as a remarkable food supplement and possesses significant hypoglycemic activity [9].…”

Section: Discussionmentioning

confidence: 99%

Potential Antitumor Activity and Apoptosis Induction of Glossostemon bruguieri Root Extract against Hepatocellular Carcinoma Cells

Alwahibi

Khalil

Ibrahim

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Glossostemon bruguieri (moghat) is used as a nutritive and demulcent drink. This study was performed to investigate the antiproliferative effects of moghat root extract (MRE) and its apoptotic mechanism in hepatocellular carcinoma (HCC) cells, HepG2 and Hep3B. MTT assay, morphological changes, apoptosis enzyme linked immunosorbent assay, caspase and apoptotic activation, flow cytometry, and immunoblot analysis were employed. The IC50 of MRE for HepG2 (910 ± 6 μg/ml) and for Hep3B (1510 ± 5 μg/ml) induced significant growth-inhibitory effects against HCC cells, with no cytotoxic effect on normal hepatocytes. MRE treatment induced apoptotic effects to HepG2 cells in a caspase-dependent manner and via upregulating p53/p21 and PCNA. The upregulation of p21 was controlled by p53 expression in HepG2 but not in Hep3B despite upregulation of Bax protein in both cell lines. Interestingly, p21 may be a remarkable switch to G1 arrest in HepG2 cells, but not in Hep3B cells. In addition, Fas- and mitochondria-mediated pathways were found to be involved in MRE-induced apoptosis in Hep3B cells. The GC-MS analysis of MRE revealed two major constituents of pharmaceutical importance: the flavonoid apigenin (17.04%) and the terpenoid squalene (11.32%). The data presented in this paper introduces G. bruguieri as a promising nontoxic herb with therapeutic potential for HCC. To the authors' knowledge, the present study provides the first report on the anticancer activity of MRE on HCC cells.

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Section: Discussionmentioning

confidence: 99%