T he year 2020 witnessed the emergence and persistence of an invisible virus-COVID-19-that changed our world and has killed nearly 4 million people. 1 Human to human airborne transmission was the mechanism of death. Science led to the pathogen identification, sequencing, and creation of mRNA vaccines, and complemented by public health measures including social distancing, mask wearing, and handwashing decreased transmission.A more pernicious and longer lasting virus has lived among us for centuries and has led to countless lives lost. That virus is racism. The vector is the hate of ''Other.'' Although we are one human race, differential treatment by societal racial/ethnic categories holding one group superior to another has led to untold suffering. In the medical literature, we have identified race as a factor in disparate health outcomes. In fact, race in and of itself does not lead to disparities, but racism does.In this editorial, we aim to highlight the destructive impact of racism in science and the limits of using race as an explanatory variable. We then will discuss how best to incorporate race/ethnicity in surgical research. Finally, we suggest remedies to the race conundrum.