The health and safety of workers is the primary concern of occupational health nurses. The purpose of this study was to identify the global occupational health and safety responsibilities of occupational health nurses based in the United States and factors contributing to these global responsibilities. A total of 2,123 American Association of Occupational Health Nurses, Inc. members completed a web-based survey and were included in the study. Approximately 12% (n = 256) of the respondents worked globally. Occupational health nurses with three or four national certifications, OR (odds ratio) = 2.07, 95% confidence interval (CI) [1.08, 3.98], more than 15 years of occupational health nursing experience, OR = 1.23, 95% CI [1.08, 1.39], and a doctoral degree, OR = 2.89, 95% CI [1.40, 5.99], were most likely to work globally. Advanced practice nurses, OR = 1.55, 95% CI [1.12, 2.15], occupational health nurses who worked for large employers, OR = 1.74, 95% CI [1.29, 2.33], and those who supervised other nurses, OR = 1.74, 95% CI [1.29, 2.34], were also more likely to work globally. In contrast, occupational health nurses who personally provided direct care to workers were less likely to work globally, OR = 0.60, 95% CI [0.44, 0.81]. The findings of this study provide direction for future education, practice, and research to increase global responsibilities among occupational health nurses in the United States.