Background: There is a growing interest in exploring the prevalence of comorbid depression in patients with hypertension, and its impact on their physical functioning, quality of life, and healthcare utilization. However, limited data is available from developing countries, particularly Saudi Arabia, on the prevalence of depression in patients with hypertension. Aim: The main objective of our study was to investigate the prevalence of depression and associated factors among hypertensive patients attending a tertiary health care clinic in Jeddah, Saudi Arabia. Methods: We conducted a cross-sectional study, with 211 hypertensive patients attending the Out-Patient Department of King Abdulaziz University Hospital in Jeddah, for a period of 1-month commencing from 15th October to 14th November 2016. Hypertensive patients were given a structured questionnaire regarding socio-demographic data, associated risk factors, and the Beck Depression Inventory-1a (BDI) scale (valid in Arabic version) to assess Depression level. Blood pressure was measured using a manual mercury column sphygmomanometer. Result: 211 hypertensive patients were studied, 127 (60.2%) patients were males and 84 (39.8%) were female. The mean BDI score for all hypertensive patients in this study was 7.35 ± 11.68. The proportion of hypertensive patients with depression (BDI score ≥20) was 20.7%. Conclusion: Depression is highly prevalent in hypertensive patients in Saudi Arabia. Further research into effective management and screening for depression in hypertensive patients is warranted.