Culture-negative endocarditis with neurologic presentations and dramatic response to heparin: a case report

Sheibani, Hossein; Salari, Mohammad; Azmoodeh, Elham; Kheirieh, Amirhessam; Chaghazardi, Sara

doi:10.1186/s12879-020-05206-0

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…It’s been reported that more than 70% of survivors have different degrees of nerve injury after surgery, and the degree of disability varies [ 6 ]. As the proportion of the elderly population worldwide increases year by year, cardiovascular and cerebrovascular diseases represented by cerebral hemorrhage gradually invade the health of the elderly, which seriously impair their quality of life, and pose a serious threat to their later life [ 7 , 8 ]. Therefore, more and more people are gradually paying attention to the prevention and treatment of cardiovascular and cerebrovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The risk factors of intracranial infection in patients with intracerebral hemorrhage undergone hematoma puncture: what should we care

Han¹,

Yu²,

Liu³

et al. 2020

BMC Infect Dis

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Background Intracranial infection after puncture of cerebral hematoma in patients with intracerebral hemorrhage is very common in the department of neurosurgery, yet the relevant risks remain unknown. We attempted to analyze the risk factors of intracranial infection after puncture of cerebral hematoma, to provide insights into the management of patients with intracerebral hemorrhage after puncture of cerebral hematoma. Methods Patients with intracerebral hemorrhage after puncture of cerebral hematoma treated in our hospital from January 2017 to January 2020 were selected, the related characteristics of intracranial infection and no infection patients were compared. Logistic regression analyses were conducted to analyze the risk factors for intracranial infection after puncture of cerebral hematoma. Results A total of 925 patients with puncture of cerebral hematoma were included. The incidence of postoperative intracranial infection was 7.03%. There were significant statistical differences between the infected group and the no infection group in the American Association of Anesthesiologists (ASA) grade, length of hospital stay, consecutive operation, duration of surgery, extra-ventricular drainage (EVD) use (all p < 0.05). There was statistically significant difference in the duration of EVD between the infection and no infection groups (p = 0.002), and there was no significant difference in the frequency of EVD insertion between the two groups (p = 0.094). The length of hospital stay≥10 days (OR1.832, 1.062–3.158), consecutive operation (OR2.158, 1.358–3.430), duration of surgery≥4 h (OR1.581, 1.031–2.425), EVD use (OR1.694, 1.074–2.670), and duration of EVD ≥ 7 days (OR2.699, 1.689–4.311) were the risk factors of intracranial infection in patients with intracerebral hemorrhage after puncture of cerebral hematoma (all p < 0.05). Conclusion Clinical medical workers should take corresponding preventive measures against the different risk factors for prevention of intracranial infection in patient with puncture of cerebral hematoma.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: The risk factors of intracranial infection in patients with intracerebral hemorrhage undergone hematoma puncture: what should we care

Han¹,

Yu²,

Liu³

et al. 2020

BMC Infect Dis

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“…The absence of positive blood culture in the presence of vegetation also agrees with reports by Jiang 13 ,Ebato 14 and Sheibani and associates 15 . The negative blood culture in this case report could be due to the administration of several antimicrobials in the referring hospital.…”

Section: Discussionsupporting

confidence: 90%

Multiple Brain Abscesses In A Child With Infective Endocarditis

FWACS, FMCR,

PON, BEd, PhD,

FWACS, Mni,

et al. 2023

IJHMR

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Background: Infective endocarditis is a lethal infection affecting the endocardium of the heart and the valves.The causes are varied with staphylococcus aureus and streptococcus as the major causative agents.The triad of fever exceeding 38oc,vegetation in the heart and blood culture of the causative agents are the hallmarks of the diagnosis .The disease is known to be affect all ages with the very young age group, those with congenital heart disease and those on cardiac prosthesis as the most vulnerable. Septic emboli from the septic vegetation can spread to the brain, kidney, spleen, and lungs resulting in massive metastatic infections.It therefore has multisystemic manifestations and complications. Though neurological complications are common, brain abcess is known to be rare constituting only 1.0% of neurological complications. Objective: The study aimed at reporting occurrence of both cerebral and cerebellar micro- and macro-abscesses in a 3 year boy with infective endocarditis; a rare occurrence in the literature. Methods: This case report was carried out at University College Hospital Ibadan. Results: The boy presented with fever of 38oc for five weeks, convulsions and altered state of consciousness for ten days..In course of treatment patient however developed irritability and aggressive behaviour, which attracted the use of largactil to which he reacted with extrapyramidal signs and convulsions. Within the week he developed yellowness of the eyes and increase in abdominal girth. Patient had cranial computed tomography (CT) after plain skull X-rays and was referred to University College Hospital Ibadan as a result of the radiologically diagnosed brain abscess seen on CT images. child had grunting respiration with dyspnea, and the respiratory rate was 50/mm. However, the chest was clinically clear. In the cardiovascular system (CVS); the pulse was 140/mm, with moderate volume. The blood pressure (BP) was l60/110 mmHg. The first and second heart sounds were heard with a gallop rhythm. Cranial CT scan showed multiple ring enhancing hypodense lesions with surrounding hypodensity measuring 1cm in diameter and above with only a few measuring less than 1.0cm in both cerebral hemispheres and cerebelli in keeping with multiple cerebral and cerebellar abscesses. An echocardiography showed a brightly echogenic spot attached to the papillary muscle in the left ventricle suggesting vegetation consistent with an infective endocarditis. Retroviral test was negative for both type I and II.Blood culture — was negative, however urine culture yielded klebsiella sp. Serum urea, creatinine, Ca2+ and P04 were all elevated.The abdominal ultrasound scan confirmed the hepatosplenomegaly with decreased echogenicity but both kidneys appeared normal.There was no demonstrable ascitis. The boy was placed on antimicrobials; and had craniotomy for the drainage of the macroabscesses. He improved significantly. His renal and cardiac condition equally improved; he was subsequently discharged to continue treatment in the the paediaric outpatient. The infective endorcarditis still poses enormous challenge in management and the condition calls for multi disciplinary approach. It requires high index of suspicion for early detection; as well deployment of multiple imaging modalities by the cardiologists and radiologists to arrive at a more accurate diagnosis for effective patient management. This may save financial and material resources on part of the patients, care givers, the facility managers and the society at large.

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Culture-negative endocarditis with neurologic presentations and dramatic response to heparin: a case report

Cited by 2 publications

References 19 publications

RETRACTED ARTICLE: The risk factors of intracranial infection in patients with intracerebral hemorrhage undergone hematoma puncture: what should we care

RETRACTED ARTICLE: The risk factors of intracranial infection in patients with intracerebral hemorrhage undergone hematoma puncture: what should we care

Multiple Brain Abscesses In A Child With Infective Endocarditis

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