Culture of<i>T. whipplei</i>from the Stool of a Patient with Whipple's Disease

Raoult, Didier; Fénollar, Florence; Birg, Marie-Laure

doi:10.1056/nejmc061049

Cited by 52 publications

(34 citation statements)

References 5 publications

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“…The possibility that T. whipplei overgrowth could lead to lung disease is supported by the pulmonary manifestations of Whipple's disease and the finding that T. whipplei is abundant in the lung of subjects with other pulmonary diseases. Because T. whipplei is resistant to growth with standard culture techniques (42), its importance in HIV-associated lung disease may be underappreciated. Alternative methods to cultural techniques for detecting T. whipplei in clinical samples have been extensively developed (14), but are not typically used for patients with acquired immune deficiency syndrome.…”

Section: Discussionmentioning

confidence: 99%

Widespread Colonization of the Lung by Tropheryma whipplei in HIV Infection

Lozupone

Cota‐Gomez

Palmer

et al. 2013

Am J Respir Crit Care Med

177

160

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Section: Discussionmentioning

confidence: 99%

Widespread Colonization of the Lung by Tropheryma whipplei in HIV Infection

Lozupone

Cota‐Gomez

Palmer

et al. 2013

Am J Respir Crit Care Med

177

160

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“…14 Tropheryma whipplei is known to be viable in human fecal and saliva samples, suggesting that the bacterium might be transmitted through both fecal-oral and oro-oral routes. 26,27 Depending on the living conditions of the subjects, either method of transmission may be prevalent.…”

Section: Discussionmentioning

confidence: 99%

Looking for Tropheryma whipplei Source and Reservoir in Rural Senegal

Keïta

Mediannikov²,

Ratmanov³

et al. 2013

The American Society of Tropical Medicine and Hygiene

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Abstract. Tropheryma whipplei, the bacterium linked to Whipple's disease, is involved in acute infections and asymptomatic carriage. In rural Senegal, the prevalence of T. whipplei is generally high but is not homogeneous throughout households in the same village. We studied environmental samples collected in two Senegalese villages and conducted the survey to investigate the difference between households. Overall, the comparison between five households with very high T. whipplei prevalence and three households without any registered cases showed that the only difference was the presence of toilets in the latter (1/5 versus 3/3; P = 0.01423). Among the 1,002 environmental specimens (including domestic and synanthropic animals and dust sampled in households) tested for T. whipplei DNA, only four specimens were slightly positive. Humans are currently the predominant identified reservoir and source of T. whipplei in these populations. Limited access to toilets and exposure to human feces facilitate the fecal-oral transmission of T. whipplei.

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“…In addition, disinfection of patient samples by filtration and pretreatment with glutaraldehyde greatly improves the success rate (25). Culture of T. whipplei is complicated by the large numbers of commensal bacteria present in saliva and stool samples (7,13,27) that would infect and overgrow these bacterial cultures, thus rendering it almost impossible to reliably establish the presence of T. whipplei through culture of patient samples.…”

Section: Bacteriology Culturementioning

confidence: 99%

“…Eighty percent of relatives of carriers had positive stool samples, and 20% of relatives had positive saliva samples (16). This suggests that oral-oral and fecal-oral transmission with this bacterium occurs (25,27). In a study on gastroenteritis in 2-to 4-year-olds, a clonal outbreak of T. whipplei was found, which indicates that it is circulating in the population or their direct environment (15).…”

Section: Human Carriage and Human-to-human Transmissionmentioning

confidence: 99%

Clinical Manifestations, Treatment, and Diagnosis of Tropheryma whipplei Infections

et al. 2017

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SUMMARY Whipple's disease is a rare infectious disease that can be fatal if left untreated. The disease is caused by infection with Tropheryma whipplei, a bacterium that may be more common than was initially assumed. Most patients present with nonspecific symptoms, and as routine cultivation of the bacterium is not feasible, it is difficult to diagnose this infection. On the other hand, due to the generic symptoms, infection with this bacterium is actually quite often in the differential diagnosis. The gold standard for diagnosis used to be periodic acid-Schiff (PAS) staining of duodenal biopsy specimens, but PAS staining has a poor specificity and sensitivity. The development of molecular techniques has resulted in more convenient methods for detecting T. whipplei infections, and this has greatly improved the diagnosis of this often missed infection. In addition, the molecular detection of T. whipplei has resulted in an increase in knowledge about its pathogenicity, and this review gives an overview of the new insights in epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of Tropheryma whipplei infections.

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Culture ofT. whippleifrom the Stool of a Patient with Whipple's Disease

Cited by 52 publications

References 5 publications

Widespread Colonization of the Lung by Tropheryma whipplei in HIV Infection

Widespread Colonization of the Lung by Tropheryma whipplei in HIV Infection

Looking for Tropheryma whipplei Source and Reservoir in Rural Senegal

Clinical Manifestations, Treatment, and Diagnosis of Tropheryma whipplei Infections

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