Cumulative delivery rates after ICSI with donor spermatozoa in different age groups

Abstract

This retrospective cohort study followed a total of 364 women from their first fresh, donor intracytoplasmic sperm injection (ICSI) cycle through to up to six ICSI cycles. All patients started their treatment between January 2003 and December 2007. Live delivery after 25 weeks of gestation was the main outcome measure. The overall crude cumulative delivery rate (CDR) after six cycles was 66% while the overall expected CDR was 90%. In women aged 38-39 years, the crude and expected CDR after six cycles were 54% and 82%, respectively. In women aged 30-37 years, the crude and expected CDR after six cycles were 66% and 91%, respectively. In women aged 20-29 years the crude and expected CDR after six cycles were 81% and 93%, respectively. No significant difference was found between the CDR of patients who had a primary ICSI treatment (no previous intrauterine insemination) and patients who had previous intrauterine insemination. This study corroborates the impact of age on ICSI with donor spermatozoa.

Donor sperm insemination after failed intra-couple intracytoplasmic sperm injection

“…The dropout rate per cycle increased as a function of cycle number (Table 2). A similar result has been reported for ICSI with donor sperm [De Brucker et al 2014]. The only significant parameter associated with drop out was AID female age (Supplement 2).…”

Impact of thyroid autoimmunity on cumulative delivery rates in in vitro fertilization/intracytoplasmic sperm injection patients

“…The outcome measure associated with this method is referred to as the ''Expected cumulative delivery rate.'' The methods of this analysis have been extensively described in previous studies (12,13,14,15). Because these outcome measures cannot be transformed to a similar unit, the outcomes of both methods cannot be readily compared.…”

In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes

“…Within those whose object of evaluation was female age only, a negative relationship between IVF/ICSI outcomes and rising female age was predominant (Malizia et al, 2009;Cetinkaya et al, 2013;De Brucker et al, 2014;Tan et al, 2014;Yilmaz et al, 2017;Mahesan et al, 2018). When evaluating the success of any ART technique, the LBR is the ultimate and most desired outcome.…”

“…Since the beginning of this century, a decline in the number of children and a temporal delay in childbearing have been verified in developed countries. Among other causes, the growth in contraception, female emancipation, increase in economic wealth, personal education, life expectancy, and social normalization of divorce and mixed families, have contributed to delayed parenthood (De Brucker et al, 2014;Meijerink et al, 2016;O'Brien et al, 2017;Carrasquillo et al, 2019). Both fecundity and fertility decrease with increasing age (O'Brien et al, 2017), causally turning couples to assisted reproductive technology (ART) to conceive.…”

“…Among all the predicting factors of ART outcomes that are studied, female age is the most frequently addressed, being currently proven that increasing female age results in decreased fertility (De Brucker et al, 2014). Nevertheless, the reason for loss of fertility with female aging is not known to full extent.…”