This study investigates strategies for improving the 3D milling of Titanium Alloy Grade 5 (Ti6Al4V) by optimizing machining parameters and cutting tool engagement techniques. Ti6Al4V presents significant machining challenges due to its low machinability index (20%), which directly impacts manufacturing efficiency. High temperatures during machining, often exceeding 8820C, lead to phase transformations, creating a harder Beta lamellar equiaxed microstructure. This, coupled with the alloy's poor thermal conductivity, results in heat concentration at the cutting tool interface, accelerating thermo-chemical wear and potentially catastrophic tool failure. This study explores how controlled cooling methods, coupled with appropriate lubrication, can effectively dissipate heat and flush away chips, mitigating the detrimental effects of high temperatures. Furthermore, the selection of cutting tool materials and coatings with high thermal conductivity and chemical inertness, along with aggressive rake angles and higher relief angles, are examined as methods to improve shearing, minimize smearing, and enhance surface quality. By optimizing these parameters, this study aims to provide manufacturers with practical strategies to overcome the challenges of Ti6Al4V machining, ultimately increasing tool life and overall milling efficiency.