CuO-CNT Nanocomposite/Ionic Liquid Modified Sensor as New Breast Anticancer Approach for Determination of Doxorubicin and 5-Fluorouracil Drugs

Abstract

The amplified voltammetric sensor, a novel approach was used for the determination of two anticancer drugs (doxorubicin and 5-fluorouracil). The novel sensor was fabricated by surface amplification of carbon paste electrode (CPE) with 1-ethyl-3-methylimidazolium tetrafluoroborate (EMITFB) and CuO decorated on single wall carbon nanotubes (CuO-SWCNTs). The EMITFB/CuO-SWCNTs/CPE creates a dramatic improvement in oxidation reaction of doxorubicin in aqueous solution. The main advantages of EMITFB/CuO-SWCNTs/CPE compared with a simple sensor are an increase of about × 3.5 in current and a decrease of about 60 mV in the oxidation potential of doxorubicin. Doxorubicin and 5-fluorouracil can be oxidized at potentials of approximately 680 and 970 mV on EMITFB/CuO-SWCNTs/CPE surface that may be sufficient for the simultaneous determination of drugs in a mixture. Doxorubicin and 5-fluorouracil were observed at detection limits of 6.0 nM and 0.4 μM, respectively, on EMITFB/CuO-SWCNTs/CPE surface. EMITFB/CuO-SWCNTs/CPE was efficiently used in the detection of doxorubicin in injection and serum samples.

Doxorubicin Anticancer Drug Monitoring by ds-DNA-Based Electrochemical Biosensor in Clinical Samples

“…However, due to the drug’s adverse effects, its regulated dosage is essential in chemotherapy [ 10 ]. Therefore, its continuous measurement in biological environments following treatment is crucial and required [ 11 , 12 , 13 , 14 , 15 ]. Numerous methods have been used for this purpose, such as high-performance liquid chromatography (HPLC), spectroscopic methods, and electrochemical sensors [ 11 , 16 , 17 , 18 , 19 ].…”

A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe3O4-SWCNTs/Ionic Liquid Paste Sensor

“…Nanomaterials have created unique properties and dramatically changed various analytical treatment techniques [ 57 , 58 , 59 , 60 ]. One of the unique features of nanomaterials is their high electrical conductivity which has created favorable conditions for the design of sensitive electrochemical sensors [ 61 , 62 , 63 ]. Among these, high electrical conductivity carbon/metal nanocomposites were proposed in recent years to manufacture various electrochemical sensors [ 64 ].…”

A DNA Based Biosensor Amplified With ZIF-8/Ionic Liquid Composite for Determination of Mitoxantrone Anticancer Drug: An Experimental/Docking Investigation

“…Moreover, the highest concentrations of mitoxantrone were detected in the heart, liver, and thyroid (Fox, 2004). Assay of anticancer drugs in biological samples such as blood is one of the most important strategies available to monitor the harmful effects of such drugs on the body (Bolanowska et al, 1983;Baghayeri et al, 2014Baghayeri et al, , 2017Baghayeri et al, , 2018aBeitollahi et al, 2014;Veisi et al, 2015;Fouladgar, 2018). From the methods reported for measuring the pharmaceutical and biological compounds, electrochemical methods with more advantages such as simplicity of analysis method, low cost, and fast analysis are considered to be more important compared to the other methods (Yuan et al, 2013(Yuan et al, , 2017Mozaffari et al, 2014;Eren et al, 2015;Movaghgharnezhad and Mirabi, 2019).…”