Cuproptosis patterns in papillary renal cell carcinoma are characterized by distinct tumor microenvironment infiltration landscapes

Abstract

Cuproptosis is a novel kind of programmed cell death that has been linked to tumor development, prognosis, and responsiveness to therapy. Nevertheless, the precise function of cuproptosis-related genes (CRGs) in the tumor microenvironment (TME) remains unknown. We characterized the genetic and transcriptional changes of CRGs in papillary renal cell carcinoma (PRCC) samples and analyzed the expression patterns in two separate cohorts. We observed that two unique cuproptosis-related subgroups and three separate gene subgroups were connected with clinicopathological, prognostic, and TME features of patients. Then, a risk score for predicting overall survival (OS) was created and validated in patients with PRCC. To make the risk score more clinically useful, we created a nomogram that was very accurate. A lower risk score, which was associated with higher tumor mutation burden, and immune activity, suggested a better prognosis for OS. Additionally, the risk score was shown to be substantially linked with the drug’s susceptibility to chemotherapeutic agents. Our extensive research of CRGs in PRCC identified possible roles for them in the TME, clinicopathological features, and overall survival. These findings may help advance our knowledge of CRGs in PRCC and pave the way for improved prognosis and the creation of more effective immunotherapy therapies.

Identification of a novel cuproptosis-related pattern and its tumor microenvironment infiltration characteristics in pancreatic cancer

“…In the present study, we evaluated 19 CRGs and investigated their somatic mutation, CNV, differential expression level, PPI network, methylation analysis, and biological pathway in PC. The higher frequency mutation rate of CDKN2A and downregulated CNV level further con rmed that at the time of malignancy, CNV is the main type of somatic mutation in the DNA sequence (Zhang et al 2022). These results also suggested that CNV may interfere with the expression of 19 cuproptosis genes.…”

Cuproptosis-Related LncRNA-Based Prediction of the Prognosis and Immunotherapy Response in Papillary Renal Cell Carcinoma

“…Accumulation of copper ions has been shown to enhance cell proliferation, growth, angiogenesis and metabolism [ 13 ]. Copper ion imbalance is an critical element in the development and occurrence of cancer [ 14 ]. A novel approach to treat cancer based on copper toxicity has been mentioned by Kahlson et al [ 15 ].…”