2012
DOI: 10.1016/j.bbrc.2012.05.102
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Curative and protective effects of l-arginine on carbon tetrachloride-induced hepatotoxicity in mice

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Cited by 34 publications
(24 citation statements)
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“…In the line with our results Moustafa & Badria, (2010) who reported that l-arginine was significantly decreased serum levels of ALT, AST, lipid peroxidation and OH radicals when compared to hepatotoxic group, due to their antioxidant effect and their ability to act as a free radical scavenger and showed that severe decrease in albumin by CDDP injection tended to be normalized by the effect of l-arginine. It has been shown previously that l-arginine treatment have anti-oxidant effect in carbon tetrachloride-induced (CCl4) hepatic injury in mice [62].The current work was supported by the results of [26], in which l-arginine can ameliorate the kidney dysfunction and that was related to the improvement of the functional status of the liver . In addition to, larginine administration resulted in reversed alterations in antioxidant defense system components in liver from rats with low resistance to hypoxia [63].…”
Section: Influence Of L-arginine On Cisplatin-induced Hepatotoxicity supporting
confidence: 77%
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“…In the line with our results Moustafa & Badria, (2010) who reported that l-arginine was significantly decreased serum levels of ALT, AST, lipid peroxidation and OH radicals when compared to hepatotoxic group, due to their antioxidant effect and their ability to act as a free radical scavenger and showed that severe decrease in albumin by CDDP injection tended to be normalized by the effect of l-arginine. It has been shown previously that l-arginine treatment have anti-oxidant effect in carbon tetrachloride-induced (CCl4) hepatic injury in mice [62].The current work was supported by the results of [26], in which l-arginine can ameliorate the kidney dysfunction and that was related to the improvement of the functional status of the liver . In addition to, larginine administration resulted in reversed alterations in antioxidant defense system components in liver from rats with low resistance to hypoxia [63].…”
Section: Influence Of L-arginine On Cisplatin-induced Hepatotoxicity supporting
confidence: 77%
“…on the 1st day and administered l-arginine (200mg/ kg i.p.) [26], for 5 consecutive days. (5) Co-administered Sly with l-arginine group (curative): rats were administered single dose of CDDP (7.5 mg/ kg i.p.)…”
Section: Pharmacological Treatmentmentioning
confidence: 99%
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“…Free radicals are very reactive and harmful species that produced normally under normal metabolic conditions if excessively produced or not adequately scavenged via anti-oxidation defence system, oxidative stress state results [17]. Free radicals can damage all components of the cell especially lipids [18].…”
Section: Introductionmentioning
confidence: 99%
“…Under normal conditions, the free radicals which are produced are scavenged by a repertoire of enzymatic antioxidants like SOD, catalase, glutathione peroxidase (GPx), etc. and also by non-enzymatic antioxidants like vitamin C, a-tocopherol, cerulo-plasmin, GSH etc., thus preventing the oxidative stress 23,24 .…”
mentioning
confidence: 99%