Curative treatment of pancreatic functioning insulinoma with stereotactic ablative radiation therapy: case report

Alsuhaibani, Aws Abdulrahman; Alsuhaibani, Abdullah; Hassan, Tareq S

doi:10.18203/2349-2902.isj20215153

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Surgical resection is the preferred method for treating pancreatic insulinomas, with the choice of surgical technique depending on the tumor's localization. If surgery poses severe complications with a high risk of mortality, stereotactic ablative radiotherapy is a highly precise alternative method [11,12].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Pancreatic Insulinoma, Sleep Apnea, and Hypertension

2024

Cardiol Res Cardiovasc Med

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Introduction: Pancreatic insulinomas are rare, usually benign, small neuroendocrine tumors that occur more frequently in women, with an average age of 47 years. Insulinomas are characterized by chronic hyperinsulinemia leading to recurrent hypoglycaemia. There is evidence that hyperinsulinemia and insulin resistance may be initial events in the genesis of arterial hypertension. The presumed link between hyperinsulinemia and hypertension is more common in individuals of European descent than in those of African descent. On the other hand, sleep apnea is one of the common causes of secondary hypertension. Case presentation: In this study, we present a 61-year-old male of Roma ethnicity with pancreatic insulinoma, hyperinsulinemia, recurrent hypoglycaemia, arterial hypertension, and sleep apnea. The clinical features of insulinoma include hypoglycaemia with neuroglycopenic symptoms, including mental confusion and behavioural changes. In the case of this individual patient, due to the development of resistant hypertension accompanied by headaches and ringing in the ears, intensified antihypertensive drug therapy was implemented. However, despite these measures, blood pressure regulation remained highly challenging. Conclusion: Pancreatic insulinoma in a 61-year-old male of Roma ethnicity with neuroglycopenic symptoms and the development of paroxysmal hypertension is a rare occurrence, despite hypertension typically not being associated with insulinoma. Sleep apnea serves as an additional exacerbating factor for the onset of secondary hypertension, further complicating blood pressure regulation.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Pancreatic Insulinoma, Sleep Apnea, and Hypertension

2024

Cardiol Res Cardiovasc Med

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Stereotactic Body Radiation Therapy for Symptomatic Pancreatic Insulinoma: Two-Case Report and Literature Review

Namysl-Kaletka,

Wydmanski,

Debosz-Suwinska

et al. 2024

Current Oncology

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Insulinoma is the most common functional neuroendocrine tumor of the pancreas, with the main clinical symptom being hypoglycemia. The standard treatment is surgery, but some patients are not eligible for surgery, while in those operated on, the risk of perioperative complications is up to 30%. Diazoxide treatment to prevent hypoglycemia is effective only in 50% of patients. To prevent tumor growth and hormonal excess, stereotactic radiotherapy may be an alternative to surgical treatment. In our paper, we present two cases of patients with insulinoma treated successfully with stereotactic body radiation therapy (SBRT).

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Curative treatment of pancreatic functioning insulinoma with stereotactic ablative radiation therapy: case report

Cited by 2 publications

References 15 publications

A Rare Case of Pancreatic Insulinoma, Sleep Apnea, and Hypertension

A Rare Case of Pancreatic Insulinoma, Sleep Apnea, and Hypertension

Stereotactic Body Radiation Therapy for Symptomatic Pancreatic Insulinoma: Two-Case Report and Literature Review

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