Curcumin–amino acid conjugates: Synthesis, antioxidant and antimutagenic attributes

Parvathy, K. S.; Negi, Pradeep Singh; Srinivas, P.

doi:10.1016/j.foodchem.2009.10.047

Cited by 81 publications

(55 citation statements)

References 22 publications

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“…Previous curcumin prodrugs have been synthesized with amino acids and piperic acid as promoieties. 29,30 Recently, polymeric prodrugs with drug molecules conjugated to a polymer backbone such as polyethylene glycol (PEG) and polyvinylpyrrolidone have shown promise in drug delivery. [31][32][33] The use of PEG as a promoiety to attach to drug molecules known as PEGylation is an accepted strategy for human therapy that takes advantage of the safety profile of PEG.…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Carboxylic Ester Spacers on Chemical Stability, Release Characteristics, and Anticancer Activity of Mono-PEGylated Curcumin Conjugates

Wichitnithad

Nimmannit

Callery

et al. 2011

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Effects of Different Carboxylic Ester Spacers on Chemical Stability, Release Characteristics, and Anticancer Activity of Mono-PEGylated Curcumin Conjugates

Wichitnithad

Nimmannit

Callery

et al. 2011

Journal of Pharmaceutical Sciences

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“…For example, structural modification or cyclodextrin complexation has been used as molecular strategies to enhance the oral bioavailability of curcumin. 35,36 Researchers have also investigated nanoscale formulations of curcumin, such as liposomes, microemulsions, and micelles, for potential therapeutic applications. [37][38][39][40][41][42] The nanoscale effect by which such drug delivery systems improve the oral performance of curcumin involves increasing the surface area and interactions of curcumin, thereby providing better water dispersibility to enhance its absorption.…”

Section: Resultsmentioning

confidence: 99%

Silica-coated flexible liposomes as a nanohybrid delivery system for enhanced oral bioavailability of curcumin

Li¹,

Zhang²,

Su³

et al. 2012

IJN

107

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Abstract:We investigated flexible liposomes as a potential oral drug delivery system. However, enhanced membrane fluidity and structural deformability may necessitate liposomal surface modification when facing the harsh environment of the gastrointestinal tract. In the present study, silica-coated flexible liposomes loaded with curcumin (CUR-SLs) having poor water solubility as a model drug were prepared by a thin-film method with homogenization, followed by the formation of a silica shell by the sol-gel process. We systematically investigated the physical properties, drug release behavior, pharmacodynamics, and bioavailability of CUR-SLs. CURSLs had a mean diameter of 157 nm and a polydispersity index of 0.14, while the apparent entrapment efficiency was 90.62%. Compared with curcumin-loaded flexible liposomes (CURFLs) without silica-coatings, CUR-SLs had significantly higher stability against artificial gastric fluid and showed more sustained drug release in artificial intestinal fluid as determined by in vitro release assays. The bioavailability of CUR-SLs and CUR-FLs was 7.76-and 2.35-fold higher, respectively, than that of curcumin suspensions. Silica coating markedly improved the stability of flexible liposomes, and CUR-SLs exhibited a 3.31-fold increase in bioavailability compared with CUR-FLs, indicating that silica-coated flexible liposomes may be employed as a potential carrier to deliver drugs with poor water solubility via the oral route with improved bioavailability.

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“…In the case of many foods such as different cultivars of apple, honey, and various vegetables, the extracted or purified bio-actives did not show good correlation between the antioxidant and antimutagenic activities [20,21,[50][51][52][53][54][55]. However, some antimutagenic compounds which are not potent antioxidants on their own but can be converted into molecules that display good antioxidant activity as reported in case of several amino acid conjugates of curcumin demonstrated very high antimutagenic activity against NaN 3 and methyl methanesulfonate (MMS) in Ames test [56].…”

Section: Fruits and Vegetables As Dietary Sources Of Antimutagensmentioning

confidence: 99%

Fruits and Vegetables as Dietary Sources of Antimutagens

Gautam¹,

Saxena²,

Kumar³

2016

J Food Chem Nanotechnol

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Mutation is the process leading to heritable changes in the genetic material of an organism and caused mainly by the external factors, including chemical and physical agents, or can also occur spontaneously due to errors in DNA replication, repair, and recombination. Agents contributing to the mutagenic burden in the environment could be from industrial sources, wide spectrum applications of biocides in the agriculture, and other contaminants. As many of these mutagenic chemicals can induce severe disorders in humans including cancer and a large spectrum of inherited diseases, it is important to detect such mutagenic agents precisely and rapidly, and also look for an approach to combat them. Natural occurring dietary antimutagens primarily from health protective foods such as fruits and vegetables could provide a mechanism to counteract the deleterious effect of these mutagens. The World Health Organization (WHO) indicates that one-third of all cancer deaths are preventable and that diet is closely linked to cancer prevention. These health protective phytochemicals particularly antimutagenic ones could provide an effective solution to these concerns. The current review deals with understanding of the mutagenic events, methods of its analysis and a brief compilation of the existing scientific findings related to the dietary sources having potential to counteract the effects of the mutagenic exposures from different sources. The review would provide an opportunity to look into the science, think about the possible future perspectives and mechanism to translate the outcome of the scientific research for benefits of the mankind.

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Curcumin–amino acid conjugates: Synthesis, antioxidant and antimutagenic attributes

Cited by 81 publications

References 22 publications

Effects of Different Carboxylic Ester Spacers on Chemical Stability, Release Characteristics, and Anticancer Activity of Mono-PEGylated Curcumin Conjugates

Effects of Different Carboxylic Ester Spacers on Chemical Stability, Release Characteristics, and Anticancer Activity of Mono-PEGylated Curcumin Conjugates

Silica-coated flexible liposomes as a nanohybrid delivery system for enhanced oral bioavailability of curcumin

Fruits and Vegetables as Dietary Sources of Antimutagens

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