Curcumin analogues as possible anti-proliferative &amp; anti-inflammatory agents

Katsori, Anna-Maria; Chatzopoulou, Maria; Dimas, Kostas; Kontogiorgis, Christos; Patsilinakos, Alexandros; Trangas, Theoni; Hadjipavlou‐Litina, Dimitra

doi:10.1016/j.ejmech.2011.03.060

Cited by 83 publications

(64 citation statements)

References 83 publications

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“…3 for the H-bond donating enolic proton. Some of the proteins that curcumin interacts with through the b-diketone moiety that may bear relevance to cancer include DNA methyltransferase 1 (Yoo and Medina-Franco, 2011), aldose reductase 1 and 2 (Muthenna et al, 2009), lipoxygenase (Katsori et al, 2011), 20S proteasome (Milacic et al, 2008), tubulin , cyclooxygenase (COX)-2 (Selvam et al, 2005) (sections III. E.1.e and III.E.7), glycogen synthase kinase-3 b (GSK3b) (Bustanji et al, 2009) (section III.E.1.b.ii), and glyoxalase I .…”

Section: A Curcumin Structure: Implications On Intermolecular Interamentioning

confidence: 99%

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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Section: A Curcumin Structure: Implications On Intermolecular Interamentioning

confidence: 99%

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Golen²,

et al. 2013

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“…Carrageenan-induced acute inflammation in rats causes increase the proinflammatory cytokine TNF-α, that are activated in certain inflammatory conditions [76]- [78].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Some Antibiotics in Curing Resistant <i>Escherichia coli</i> Infection

El-Banna¹,

El-Aziz²,

El-Mahdy³

et al. 2015

JBM

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There is growing interest in re-evaluation of older antibiotics with the wide spread of pathogen resistance, especially gram negative bacteria, which impair treatment of some infections. In contrast various studies have reported that some antibiotics have efficacy in clearing resistant bacterial infections. On account of that it was interesting to evaluate the efficacy of erythromycin, chloramphenicol and/or tenoxicam in curing and/or relieving wound infection of highly resistant Escherichia coli and investigate the possible mechanisms beyond their antibacterial activity. This was achieved through evaluating highly resistant E. coli strains in vitro using agar dilution and in vivo rat models of E. coli infected wound and acute inflammation by carrageenin, where possible mechanisms were evaluated through measuring immunological mediators and histopathological examination. This study revealed that in vivo, erythromycin alone or in combination with tenoxicam significantly improved the healing of infected skin wounds with E. coli irresspective of resistancy in vitro. In addition to the improvement of immunological mediators involved in inflammatory reaction, oxidative stress and in cytokines expression as response to the bacterial infection in vivo. On the other hand chloramphenicol neither alone nor in combination with tenoxicam, achieved any significant effect. Tenoxicam didn't show antimicrobial activity alone nor in combination with tested antibiotics in vitro, but it has shown synergestic activity in combination with tested antibiotics in vivo. Thus we concluded that immunomodulatory activity of erythromycin through anti-inflammatory and antioxidant effects was the possible mechanisms by which this antibiotic had healed infection with resistant E. coli in vivo, despite its resistancy to this antibiotic in vitro.

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“…Curcumin (Curcuma longa) is well established biologically active natural material derived from turmeric plants. Curcumin has been shown to exhibit various potential applications in medicinal chemistry [26][27][28]. Some researchers were proved that functionalization of modified curcumin has been exhibited better biological activities than raw curcumin.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antimicrobial Activity of Green-Synthesized Manganese Oxide Nanoparticles and Comparative Studies With Curcuminaniline Functionalized Nanoform

Jayandran

Balasubramanian

2017

Asian J Pharm Clin Res

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Objective: Metal oxide nanoparticles are widely attracted researchers due to their potential applications in a variety of fields, especially medicinal importance. It has been shown that biofunctionalization of metal nanoparticles with the specified bioactive materials produces the significantly improved bioactive materials with the essential biological properties and advanced features. According to the reports, manganese oxide nanoparticles (MONPs) possess highly magnetic properties leads to develop for use in research and biomedical applications. In this evaluation, we focused on the synthesis of MONPs through a green methodology and their antimicrobial activity changes when functionalized with curcuminaniline derived from turmeric plants.Methods: First, curcumin has been isolated from turmeric plant (BSR-01) to synthesize curcuminaniline biomaterial. On the other hand, manganese nanoparticles are synthesized by the green synthesis method using lemon extract and curcumin. Finally, the synthesized curcuminaniline is functionalized with MONPs. The synthesized nanoparticles are characterized by ultraviolet-visible, Fourier transform infrared, scanning electron microscope and transmission electron microscopy techniques. The antimicrobial activity of the obtained nonfunctionalized and biofunctionalized nanoforms are tested against some Gram-negative and Gram-positive bacterial strains as well as fungal strains. Results:The morphological studies represented that MONPs are of eclipsed and spherical morphology with size about 50±5 nm and biofunctionalized nanoparticles are of spherical morphology with size about 50±10 nm. The antibacterial and antifungal tests revealed that biofunctionalized MONPs are exhibited significantly higher antimicrobial activity. Conclusion:This investigation clearly demonstrated that MONPs are shown significantly higher biocidal activity when biofunctionalized with modified curcumin material. This may help in the future medicinal and pharmaceutical industries to develop new inventions.

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Curcumin analogues as possible anti-proliferative & anti-inflammatory agents

Cited by 83 publications

References 83 publications

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Efficacy of Some Antibiotics in Curing Resistant <i>Escherichia coli</i> Infection

Evaluation of Antimicrobial Activity of Green-Synthesized Manganese Oxide Nanoparticles and Comparative Studies With Curcuminaniline Functionalized Nanoform

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Curcumin analogues as possible anti-proliferative & anti-inflammatory agents

Cited by 83 publications

References 83 publications

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

Efficacy of Some Antibiotics in Curing Resistant &lt;i&gt;Escherichia coli&lt;/i&gt; Infection

Evaluation of Antimicrobial Activity of Green-Synthesized Manganese Oxide Nanoparticles and Comparative Studies With Curcuminaniline Functionalized Nanoform

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Efficacy of Some Antibiotics in Curing Resistant <i>Escherichia coli</i> Infection