Curcumin and inflammatory bowel diseases: From in vitro studies to clinical trials

Fallahi, Farzaneh; Borran, Sarina; Ashrafizadeh, Milad; Zarrabi, Ali; Pourhanifeh, Mohammad Hossein; Mahabady, Mahmood Khaksary; Sahebkar, Amirhossein; Mirzaei, Hamed

doi:10.1016/j.molimm.2020.11.016

Cited by 46 publications

(30 citation statements)

References 115 publications

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“…The most investigated bioactive compound from this point of view is curcumin. In inflamed intestine, curcumin can interact with transient potential vanilloid receptor 1 (TRPV1) improving the visceral hyperalgesia and colitis in mice (81). These results corroborate previous observations, which showed the curcumin ability to suppress the membrane TRPV1 upregulation induced by phorbol myristate acetate in the HEK293 cell line (81).…”

Section: Inflammatory Bowel Diseasesupporting

confidence: 88%

“…According to the recent epidemiological studies, countries such as the United States, the United Kingdom and the Northern Europe have a higher incidence rate of IBD comparing to the developing countries. However, recently, it has been recorded in an increase of incidence and prevalence of IBD also in developing countries with a higher frequency for UC with respect to the CD (81). There are many pharmacological approaches available to treat IBD (cyclosporine, corticosteroids, 5-aminosalicylic acid, mercaptopurines, anti-TNF-α and azathioprine).…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

“…Considering this, researchers are increasingly interested in natural bioactive compounds, which possess strong anti-inflammatory and antioxidant activities, as new promising strategies to treat the IBD (81). The most investigated bioactive compound from this point of view is curcumin.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

“…In inflamed intestine, curcumin can interact with transient potential vanilloid receptor 1 (TRPV1) improving the visceral hyperalgesia and colitis in mice (81). These results corroborate previous observations, which showed the curcumin ability to suppress the membrane TRPV1 upregulation induced by phorbol myristate acetate in the HEK293 cell line (81). Moreover, curcumin has a strong suppressive role in NLRP3 inflammasome activation in mice, down-regulating the dextran sulfate sodium (DSS)-induced K + efflux, intracellular ROS formation and cathepsin B release (81).…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

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The pharmacological basis of the curcumin nutraceutical uses: an update

Canistro¹,

Chiavaroli²,

Cicia³

et al. 2021

Pharm Adv

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Curcumin is the major phytoconstituent found in the rhizomes of Curcuma longa L. Preparations derived from the rhizome of the plant, referred as turmeric, have been used for centuries in the traditional Indian system of medicine. The recent literature has shown curcumin as one of the most interesting pleiotropic nutraceuticals capable of interacting with different molecular targets involved in chronic diseases. The present review summarizes and critically discusses the very recent literature published between 2018 and 2021. We focused on the preclinical pharmacological actions of curcumin in relation to its possible clinical application in several pathophysiological states and disturbances including inflammation and pain, as well as metabolic, cardiovascular, dermatological, and central nervous system diseases. The most relevant molecular targets of curcumin, such as transcription factors, pro-inflammatory mediators, enzymes, and protein kinase as well as pharmacokinetics in humans are also reviewed.

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Section: Inflammatory Bowel Diseasesupporting

confidence: 88%

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

See 2 more Smart Citations

The pharmacological basis of the curcumin nutraceutical uses: an update

Canistro¹,

Chiavaroli²,

Cicia³

et al. 2021

Pharm Adv

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“…CUR had shown activity against many inflammatory diseases, such as arthritis [17] and inflammatory bowel disease [18]. However, the poor water solubility of CUR limits its physiological effects and current research has suggested many possible ways to rationalize its efficacy [19,20].…”

Section: Discussionmentioning

confidence: 99%

Comparative Study on Curcumin Loaded in Golden Pompano (Trachinotus blochii) Head Phospholipid and Soybean Lecithin Liposomes: Preparation, Characteristics and Anti-Inflammatory Properties

Gao

Liu

et al. 2021

Molecules

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In this study, we compared the characteristics and in vitro anti-inflammatory effects of two curcumin liposomes, prepared with golden pompano head phospholipids (GPL) and soybean lecithin (SPC). GPL liposomes (GPL-lipo) and SPC liposomes (SPC-lipo) loaded with curcumin (CUR) were prepared by thin film extrusion, and the differences in particle size, ζ-potential, morphology, and storage stability were investigated. The results show that GPL-lipo and SPC-lipo were monolayer liposomes with a relatively small particle size and excellent encapsulation rates. However, GPL-lipo displayed a larger negative ζ-potential and better storage stability compared to SPC-lipo. Subsequently, the effects of phospholipids in regulating the inflammatory response of macrophages were evaluated in vitro, based on the synergistic effect with CUR. The results showed that both GPL and SPC exerted excellent synergistic effect with CUR in inhibiting the lipopolysaccharide (LPS)-induced secretion of nitric oxide (NO), reactive oxygen species (ROS), and pro-inflammatory genes (tumor necrosis factor (TNF)-α, interleukin 1β (IL-β), and interleukin 6 (IL-6)) in RAW264.7 cells. Interestingly, GPL-lipo displayed superior inhibitory effects, compared to SPC-lipo. The findings provide a new innovative bioactive carrier for development of stable CUR liposomes with good functional properties.

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