Curcumin and Selenium Prevent Lipopolysaccharide/Diclofenac-Induced Liver Injury by Suppressing Inflammation and Oxidative Stress

Curcumin Prevents Cyclophosphamide-Induced Lung Injury in Rats by Suppressing Oxidative Stress and Apoptosis

“…According to previous studies, CUR has revealed many pharmacological activities, including anticancer, anti-inflammatory, antioxidant, and wound healing properties [20][21][22][23][24]48,49]. Therefore, we aimed to explore its protective effect against CP-induced lung injury in rats.…”

“…These findings demonstrated the antioxidant and anti-apoptosis potential of CUR. Accordingly, previous work from Mahmoud's lab revealed the antioxidant ant anti-apoptotic effects of CUR in gentamicin-, lead acetate-, and lipopolysaccharide/diclofenac-intoxicated rats [21][22][23][24]. In these studies, CUR prevented tissue injury, suppressed lipid peroxidation, DNA damage, inflammation, and pro-apoptotic proteins, and boosted antioxidants defenses [21][22][23][24].…”

“…So, it received great consideration among scientists and researchers. CUR exerts in vivo and in vitro antioxidant effects through different mechanisms and it has the ability to neutralize ROS and reactive nitrogen species (RNS) [20][21][22][23][24]. CUR inhibits ROS across several cellular and animal models of different disorders [20][21][22][23][24][25].…”

“…CUR exerts in vivo and in vitro antioxidant effects through different mechanisms and it has the ability to neutralize ROS and reactive nitrogen species (RNS) [20][21][22][23][24]. CUR inhibits ROS across several cellular and animal models of different disorders [20][21][22][23][24][25]. It decreases the expression rates of certain proteins and lipid oxidation markers, prevents the rise in oxidative derivative compounds, and increases the levels of SOD, reduced glutathione (GSH), GPx, and CAT [20][21][22][23][24].…”

“…CUR inhibits ROS across several cellular and animal models of different disorders [20][21][22][23][24][25]. It decreases the expression rates of certain proteins and lipid oxidation markers, prevents the rise in oxidative derivative compounds, and increases the levels of SOD, reduced glutathione (GSH), GPx, and CAT [20][21][22][23][24]. In addition, CUR has the ability to modulate and control several signaling pathways resulting in accelerating apoptosis, antiproliferation, and cytotoxicity of different cancer cells [26].…”