Curcumin Antagonizes Glucose Fluctuation-Induced Renal Injury by Inhibiting Aerobic Glycolysis via the miR-489/LDHA Pathway

Xiao-mei, FU; Zhang, Jianfang; Huang, Xuanjie; Mo, Zhifeng; Sang, Ziyang; Duan, Wenfei; Huang, Wenfeng

doi:10.1155/2021/6104529

Cited by 7 publications

(6 citation statements)

References 54 publications

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“…In diabetic mice and human patients, Sas et al demonstrated the upregulation of glycolytic enzymes accompanied by increased glucose metabolism in kidneys ( 50 ). More recently, aerobic glycolysis was implicated in kidney injury caused by glucose fluctuation ( 51 , 52 ). These studies suggest the involvement of aerobic glycolysis or the Warburg effect in the development of renal diseases.…”

Section: Regulation Of Glucose Metabolism In Kidney Diseasesmentioning

confidence: 99%

Glucose Metabolism in Acute Kidney Injury and Kidney Repair

Wen

Liu

et al. 2021

Front. Med.

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The kidneys play an indispensable role in glucose homeostasis via glucose reabsorption, production, and utilization. Conversely, aberrant glucose metabolism is involved in the onset, progression, and prognosis of kidney diseases, including acute kidney injury (AKI). In this review, we describe the regulation of glucose homeostasis and related molecular factors in kidneys under normal physiological conditions. Furthermore, we summarize recent investigations about the relationship between glucose metabolism and different types of AKI. We also analyze the involvement of glucose metabolism in kidney repair after injury, including renal fibrosis. Further research on glucose metabolism in kidney injury and repair may lead to the identification of novel therapeutic targets for the prevention and treatment of kidney diseases.

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Section: Regulation Of Glucose Metabolism In Kidney Diseasesmentioning

confidence: 99%

Glucose Metabolism in Acute Kidney Injury and Kidney Repair

Wen

Liu

et al. 2021

Front. Med.

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“… 34 The condition of DKD patients was improved when LDHA was used as a therapeutic target. 31 , 35 However, serum lactate levels in DKD patients are higher than those in healthy controls, which may be affected by the use of drugs, like ARB drugs. 31 This suggests the necessity for larger sample and multicenter studies to detect serum lactate levels, while also paying attention to the effects of drugs on lactate metabolism.…”

Section: Discussionmentioning

confidence: 99%

Development of Serum Lactate Level-Based Nomograms for Predicting Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

Jiang,

Ma,

Chen

et al. 2024

DMSO

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Purpose To establish nomograms integrating serum lactate levels and traditional risk factors for predicting diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients. Patients and methods A total of 570 T2DM patients and 100 healthy subjects were enrolled. T2DM patients were categorized into normal and high lactate groups. Univariate and multivariate logistic regression analyses were employed to identify independent predictors for DKD. Then, nomograms for predicting DKD were established, and the model performance was evaluated using the area under the receiver operating characteristic curve (AUC), calibration, and decision curve analysis (DCA). Results T2DM patients exhibited higher lactate levels compared to those in healthy subjects. Glucose, platelet, uric acid, creatinine, and hypertension were independent factors for DKD in T2DM patients with normal lactate levels, while diabetes duration, creatinine, total cholesterol, and hypertension were indicators in high lactate levels group ( P <0.05). The AUC values were 0.834 (95% CI, 0.776 to 0.891) and 0.741 (95% CI, 0.688 to 0.795) for nomograms in both normal lactate and high lactate groups, respectively. The calibration curve demonstrated excellent agreement of fit. Furthermore, the DCA revealed that the threshold probability and highest Net Yield were 17–99% and 0.36, and 24–99% and 0.24 for the models in normal lactate and high lactate groups, respectively. Conclusion The serum lactate level-based nomogram models, combined with traditional risk factors, offer an effective tool for predicting DKD probability in T2DM patients. This approach holds promise for early risk assessment and tailored intervention strategies.

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“…One of the actions of miR-489 is to regulate apoptosis by targeting 3’-UTR of IGF-I, which inhibits its expression [ 54 ]. Also, glucose fluctuations reduce miR-489 expression [ 55 ]. In this way, this miRNA function appear to be related to glucose metabolism.…”

Section: Discussionmentioning

confidence: 99%

High body energy reserve influences extracellular vesicles miRNA contents within the ovarian follicle

et al. 2023

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Aiming to evaluate the effects of increased body energy reserve (BER) in Nellore cows’ reproductive efficiency, cows were fed with different nutritional plans to obtain animals with high BER (HBER; Ad libitum diet) and moderate BER (MBER: cows fed 70% of HBER group ingestion). To evaluate the BER, cows were weekly weighted and evaluated for subcutaneous fat thickness and insulin serum concentration along the experimental period. At the end of the experimental period, animals were submitted to estrous synchronization and artificial insemination. Animals were slaughtered approximately 120 h after ovulation induction and the reproductive tracts were collected for embryo recovery and samples collection. Cumulus-oocyte-complexes (COC) and follicular fluid were collected from 3–6 mm in diameter ovarian follicles to perform miRNA analysis of cumulus cells (CC) and extracellular vesicles from follicular fluid (EV FF). As expected, differences were observed among MBER and HBER groups for body weight, fat thickness, and insulin serum concentration. HBER animals showed lower ovulation and embryo recovery rates compared to MBER animals. Different miRNAs were found among CC and EV FF within groups, suggesting that the BER may influence follicular communication. This suggests that small follicles (3–6 mm diameter) are already under BER effects, which may be greater on later stages of follicular development.

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Curcumin Antagonizes Glucose Fluctuation-Induced Renal Injury by Inhibiting Aerobic Glycolysis via the miR-489/LDHA Pathway

Cited by 7 publications

References 54 publications

Glucose Metabolism in Acute Kidney Injury and Kidney Repair

Glucose Metabolism in Acute Kidney Injury and Kidney Repair

Development of Serum Lactate Level-Based Nomograms for Predicting Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

High body energy reserve influences extracellular vesicles miRNA contents within the ovarian follicle

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