Curcumin as a modulator of oxidative stress during storage: A study on plasma

Hsieh, Carl; Chandni, Ahuja; Neha, Kumari; Trishna, S.; Vani, R.

doi:10.1016/j.transci.2013.12.015

Cited by 9 publications

(11 citation statements)

References 25 publications

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“…The levels of antioxidant enzyme and protein such as GSH, GSH-Px, and catalase were significantly increased at the beginning of the storage period and throughout the storage time, which was consistent with previous studies [ 39 ]. However, we observed that the addition of resveratrol, caffeic acid, and tannic acid protects the levels of GSH, GSH-Px, and catalase in stored blood and activates them during the first two weeks of storage time.…”

Section: Resultssupporting

confidence: 92%

The Relationship of Oxidation Sensitivity of Red Blood Cells and Carbonic Anhydrase Activity in Stored Human Blood: Effect of Certain Phenolic Compounds

Huyut

Şekeroğlu

Balahoroğlu

et al. 2016

BioMed Research International

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It has been reported that many modifications occur with the increase of oxidative stress during storage in erythrocytes. In order to delay these negative changes, we evaluated whether the addition of substances likely to protect antioxidant capacity in stored blood would be useful. Therefore, we investigated the effects of resveratrol, tannic acid, and caffeic acid in lipid peroxidation and antioxidant capacity of erythrocytes in stored blood. Donated blood was taken into four CPD containing blood bags. One bag was used as the control, and the others were supplemented with caffeic acid (30 μg/mL), resveratrol (30 μg/mL), and tannic acid (15 μg/mL), respectively. Erythrocyte lipid peroxidation, sensitivity to oxidation, glutathione levels and carbonic anhydrase, glutathione peroxidase, and catalase activities were measured on days 0, 7, 14, 21, and 28. In the control group, erythrocyte malondialdehyde levels and sensitivity to oxidation were increased whereas glutathione, glutathione peroxidase, and catalase levels were decreased (p < 0.05). Resveratrol and caffeic acid prevented malondialdehyde accumulation and preserved glutathione, glutathione peroxidase, and catalase activities in erythrocytes. We demonstrated that resveratrol, caffeic acid, and tannic acid in stored blood could decrease the sensitivity to oxidation of erythrocytes in vitro but did not exhibit such effects on CA activity.

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Section: Resultssupporting

confidence: 92%

The Relationship of Oxidation Sensitivity of Red Blood Cells and Carbonic Anhydrase Activity in Stored Human Blood: Effect of Certain Phenolic Compounds

Huyut

Şekeroğlu

Balahoroğlu

et al. 2016

BioMed Research International

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“…P-SH increased in samples with higher concentrations of curcumin, indicating that few free radicals were successfully scavenged by curcumin (15,16,(18)(19)(20)(21)(22)25,29); this also indicated the reversibility of the disulfide groups to reduced SH. Similar results were observed in plasma from stored blood (64). In erythrocytes, Band 3, a protein containing six SH groups, is prone to oxidative damage.…”

Section: Discussionsupporting

confidence: 84%

Prospects of curcumin as an additive in storage solutions: a study on erythrocytes

2016

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“…There are many efficient antioxidants which can reduce the OS induced by storage [ 13 – 15 ]. For example, antioxidant effects of vitamin C (ascorbic acid) have been demonstrated in many experiments in vitro [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition to scavenging ROS and reactive nitrogen species, vitamin C can regenerate other small molecule antioxidants, such as α -tocopherol, glutathione (GSH), urate, and β -carotene, from their respective radical species [ 20 ]. Studies have reported the various changes that occur in different storage solutions, the effect of curcumin on plasma [ 15 ] and the effect of vitamin C on storage in erythrocytes [ 21 – 25 ]. However, the utilization of plasma as a mode of assessing the changes in blood, during storage with ascorbic acid as an additive, has not been explored.…”

Section: Introductionmentioning

confidence: 99%

Prospects of Vitamin C as an Additive in Plasma of Stored Blood

Vani

Ravikumar

Hsieh

et al. 2015

Advances in Hematology

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There is a dire necessity to improve blood storage and prolong shelf-life of blood. Very few studies have focused on oxidative stress (OS) in blood and its influence on plasma with storage. This study attempts to (i) elucidate the continuous changes occurring in plasma during storage through oxidant levels and antioxidant status and (ii) evaluate the influence of vitamin C (VC) as an additive during blood storage. Blood was drawn from male Wistar rats and stored for 25 days at 4°C. Blood samples were divided into control and experimental groups. Plasma was isolated every 5 days and the OS markers, antioxidant enzymes, lipid peroxidation, and protein oxidation products, were studied. Catalase activity increased in all groups with storage. Lipid peroxidation decreased in VC (10) but was maintained in VC (30) and VC (60). Although there were variations in all groups, carbonyls were maintained towards the end of storage. Advanced oxidation protein products (AOPP) increased in VC (30) and were maintained in VC (10) and VC (60). Sulfhydryls were maintained in all groups. Vitamin C could not sufficiently attenuate OS and hence, this opens the possibilities for further studies on vitamin C in combination with other antioxidants, in storage solutions.

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Curcumin as a modulator of oxidative stress during storage: A study on plasma

Cited by 9 publications

References 25 publications

The Relationship of Oxidation Sensitivity of Red Blood Cells and Carbonic Anhydrase Activity in Stored Human Blood: Effect of Certain Phenolic Compounds

The Relationship of Oxidation Sensitivity of Red Blood Cells and Carbonic Anhydrase Activity in Stored Human Blood: Effect of Certain Phenolic Compounds

Prospects of curcumin as an additive in storage solutions: a study on erythrocytes

Prospects of Vitamin C as an Additive in Plasma of Stored Blood

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