Curcumin as a putative antidepressant

Seo, Ho Jun; Wang, Sheng Min; Han, Changsu; Lee, Soo Jung; Patkar, Ashwin A.; Masand, Prakash S.; Pae, Chi Un

doi:10.1586/14737175.2015.1008457

Cited by 38 publications

(28 citation statements)

References 98 publications

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“…Therefore, it seems reasonable to assume that observed high efficacy of CLE in protecting stress triggered alterations in body weight and core temperature is mainly due to its ability to stimulate AMPK inside the gastrointestinal tract. However, the question whether or not other known bioactivities of curcuminoids observed in cellular and other in vitro models are also involved in often reported analgesics and antidepressants like efficacies of curcuminoids5, 40 still remain open or speculative only.…”

Section: Discussionmentioning

confidence: 99%

Effects of turmeric curcuminoids and metformin against central sensitivity to pain in mice

Verma

Mundkinajeddu

Agarwal

et al. 2017

Journal of Traditional and Complementary Medicine

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The reported experimental study was conducted to compare the effects of repeated daily oral doses of curcuminoids (CLE) with metformin as potential antidepressants and analgesics. Effects of a single and ten daily oral doses of CLE (5, 20, 80 mg/kg/day) and of 50 mg/kg/day metformin (MET) were compared in mice hot plate test (HPT) for analgesics. On the 11th treatment day, all animals were subjected to foot shock stress triggered hyperthermia test, and on the 12th treatment day to tail suspension test (TST) for antidepressants. Immediately thereafter, their blood levels of glucose, insulin and cortisol were quantified. Dose dependent analgesic activity of CLE was observed in HPT, whereas the metformin dose tested suppressed only pain hypersensitivity in the test. But statistically significant effects of both of them were observed in TST, and both of them also afforded protections against body weight loss and slight elevation in core temperatures induced by daily handling and repeated testing. CLE or metformin had no significant effects in foot shock stress triggered transient hyperthermic responses or on blood glucose, insulin and cortisol levels. Reported results reveal that curcuminoids as well as metformin are stress response modifiers with antidepressants like activities, but only low dose curcuminoids possess centrally acting analgesics like activities. They suggest that the bio-assay system used in this study is well suited for identifying curcuminoids like plant metabolites with analgesic and anti-stress activities, and that low dose curcuminoids are more effective as analgesics than low dose metformin.

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Section: Discussionmentioning

confidence: 99%

Effects of turmeric curcuminoids and metformin against central sensitivity to pain in mice

Verma

Mundkinajeddu

Agarwal

et al. 2017

Journal of Traditional and Complementary Medicine

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“…In animal study, chronic and systemic administration of infliximab (TNF-α inhibitor) decreases depression and anxiety-like behavior in rat model of chronic mild stress (Karson et al, 2013). Culcumin is also a natural product with strong anti-inflammatory and antioxidant effects (Seo et al, 2015). Doxycycline and minocylcine, which belong to the tetracycline family of antibiotics, also have strong anti-inflammatory effects, which may have antidepressant effects (Levine et al, 1996).…”

Section: Potential Treatment Associated With the Regulation Of Neuroimentioning

confidence: 99%

The role of neuroinflammation on pathogenesis of affective disorders

Rhie¹,

Jung²,

Shim³

2020

J Exerc Rehabil

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Accumulating evidence suggests that neuroinflammation plays an important role in etiology of psychiatric disorders. Neuronflammation involves a combination of psychological, neuroendocrine, and nervous systems resulting in changes of neurotransmitter metabolism, dysregulation of the hypothalamus-pituitary-adrenal axis, pathologic microglial cell activation, impaired neuroplasticity, and structural and functional brain changes affecting cognition and emotional behavior. Inflammatory cytokines have been postulated to be the possible link and culprit in the disruption of these systems. The outcome of any type of dysregulation of the immune system in the brain might lead to occurrence of depression, anxiety. This review focuses on the possible impact of dysregulated cytokine networks which may cause pathogenesis of affective disorders such as depression and anxiety.

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“…Although the antidepressant mechanisms of curcumin on mental disorders are not yet entirely elucidated, there has been more and more research focusing on related studies in recent years. 26,115,116 As one of the most rapidly growing fields in the psychiatric research, different mechanisms for the antidepressant effects of curcumin have been proposed, as shown in Figure 1. In the past decades, growing evidence has supported…”

Section: Mechanisms Of Curcuminmentioning

confidence: 99%

Curcumin in antidepressant treatments: An overview of potential mechanisms, pre‐clinical/clinical trials and ongoing challenges

Zhang

2020

Basic Clin Pharma Tox

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Depression is one of the most common but serious psychiatric disorders affecting millions of people globally, which has become increasingly prevalent during the past few decades. To alleviate this challenging health and social burden, various therapeutic strategies have been developed to achieve efficient treatments for depression. In particular, plenty of chemical ingredients of natural origin have been investigated as new direct antidepressants or served as adjuvants to improve the current treatment outcomes of existing antidepressant drugs. Among them, curcumin, a natural compound derived from the herb Curcuma longa, exhibits a wide range of pharmacological properties and has been considered a potent antidepressant drug with diverse mechanisms including monoaminergic imbalances (associated with serotonin, dopamine, noradrenaline and glutamate), effect on neurotransmitters, neuroprogression, the hypothalamic‐pituitary‐adrenal (HPA) axis disturbances, dysregulated inflammation and immune pathways, oxidative and nitrosative stress, and mitochondrial disturbances. In this review, multiple potential mechanisms of curcumin for treating depression demonstrated in either animal or human studies are summarized. To better understand the significant role of curcumin, specific emphasis will be placed on the aetiopathogenesis of depression. Finally, current pre‐clinical/clinical trials and ongoing challenges of curcumin used for antidepressant treatments will be discussed and their future outlooks will be briefly presented.

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Curcumin as a putative antidepressant

Cited by 38 publications

References 98 publications

Effects of turmeric curcuminoids and metformin against central sensitivity to pain in mice

Effects of turmeric curcuminoids and metformin against central sensitivity to pain in mice

The role of neuroinflammation on pathogenesis of affective disorders

Curcumin in antidepressant treatments: An overview of potential mechanisms, pre‐clinical/clinical trials and ongoing challenges

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