Curcumin assisted green synthesis of silver and zinc oxide nanostructures and their antibacterial activity against some clinical pathogenic multi-drug resistant bacteria

El-Kattan, Noura; Emam, Ahmed N.; Mansour, Ahmed S.; El-Razik, A. B. Abd; Allam, Kamilia A M; Riad, Nadia Youssef; Ibrahim, S. A.

doi:10.1039/d2ra00231k

Cited by 31 publications

(6 citation statements)

References 110 publications

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“…However, the application of curcumin has been limited in the production of ZnO NPs due to low water solubility and sensitivity to heat, light, and alkaline. Various methods have been reported for the green synthesis of ZnO NPs from curcumin using hydroxides or chemical mediators [ 21 , 22 , 23 , 24 , 25 ]. However, several disadvantages including time consumption [ 25 ], the toxicity of the chemicals used as a mediator [ 23 , 25 , 26 ], and the large size of ZnO NPs [ 21 ] are the major limitations of these methods.…”

Section: Introductionmentioning

confidence: 99%

Phytofabrication and Characterisation of Zinc Oxide Nanoparticles Using Pure Curcumin

Alallam

Doolaanea²,

Alfatama

et al. 2023

Pharmaceuticals

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Zinc oxide and curcumin, on their own and in combination, have the potential as alternatives to conventional anticancer drugs. In this work, zinc oxide nanoparticles (ZnO NPs) were prepared by an eco-friendly method using pure curcumin, and their physicochemical properties were characterised. ATR-FTIR spectra confirmed the role of curcumin in synthesising zinc oxide curcumin nanoparticles (Green-ZnO-NPs). These nanoparticles exhibited a hexagonal wurtzite structure with a size and zeta potential of 27.61 ± 5.18 nm and −16.90 ± 0.26 mV, respectively. Green-ZnO-NPs showed good activity towards studied bacterial strains, including Escherichia coli, Staphylococcus aureus and methicillin-resistant Staphylococcus aureus. The minimum inhibitory concentration of Green-ZnO-NPs was consistently larger than that of chemically synthesised ZnO NPs (Std-ZnO-NPs) or mere curcumin, advocating an additive effect between the zinc oxide and curcumin. Green-ZnO-NPs demonstrated an efficient inhibitory effect towards MCF-7 cells with IC50 (20.53 ± 5.12 μg/mL) that was significantly lower compared to that of Std-ZnO-NPs (27.08 ± 0.91 μg/mL) after 48 h of treatment. When Green-ZnO-NPs were tested against Artemia larvae, a minimised cytotoxic effect was observed, with LC50 being almost three times lower compared to that of Std-ZnO-NPs (11.96 ± 1.89 μg/mL and 34.60 ± 9.45 μg/mL, respectively). This demonstrates that Green-ZnO-NPs can be a potent, additively enhanced combination delivery/therapeutic agent with the potential for anticancer therapy.

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Section: Introductionmentioning

confidence: 99%

Phytofabrication and Characterisation of Zinc Oxide Nanoparticles Using Pure Curcumin

Alallam

Doolaanea²,

Alfatama

et al. 2023

Pharmaceuticals

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“…According to El-Kattan et al, curcumin-capped ZnO-NPs effectively against a broad range of clinically pathogenic bacteria. The occurrence can be attributed to the increased hydrophobicity of ZnO-NPs, causing strong penetration into the bacteria [ 43 ]. The role of bioactive materials as capping agents in modulating the cytotoxicity of ZnO-NPs has frequently been demonstrated [ 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis, characterization, and antiparasitic effects of zinc oxide nanoparticles-eugenol nanosuspension against Toxoplasma gondii infection

Cheraghipour,

Khudair Khalaf,

Moradpour

et al. 2023

Heliyon

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“…Antimicrobial agents, particularly antibiotics, are used to combat bacterial infections [119]. Bacteria have evolved and developed resistance to antibiotics throughout time as a result of their overuse or inadequate usage [120]. Antibacterial antibiotic resistance is one of the leading causes of treatment failure.…”

Section: Antibacterial Propertiesmentioning

confidence: 99%

Curcumin: Overview of Extraction Methods, Health Benefits, and Encapsulation and Delivery Using Microemulsions and Nanoemulsions

Ciuca

Racoviţǎ

2023

IJMS

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Curcumin is the principal curcuminoid found in the rhizomes of turmeric. Due to its therapeutic action against cancer, depression, diabetes, some bacteria, and oxidative stress, it has been used widely in medicine since ancient times. Due to its low solubility, the human organism cannot completely absorb it. Advanced extraction technologies, followed by encapsulation in microemulsion and nanoemulsion systems, are currently being used to improve bioavailability. This review discusses the different methods available for curcumin extraction from plant material, methods for the identification of curcumin in the resulting extracts, its beneficial effects on human health, and the encapsulation techniques into small colloidal systems that have been used over the past decade to deliver this compound.

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Curcumin assisted green synthesis of silver and zinc oxide nanostructures and their antibacterial activity against some clinical pathogenic multi-drug resistant bacteria

Abstract: Curcumin-assisted synthesized Ag and ZnO NPs showed significant antibacterial activity with lower minimum inhibitory concentration (MIC) against the multi-drug resistance bacteria and biocompatibility compared to traditionally used antibiotics.

Cited by 31 publications

References 110 publications

Phytofabrication and Characterisation of Zinc Oxide Nanoparticles Using Pure Curcumin

Phytofabrication and Characterisation of Zinc Oxide Nanoparticles Using Pure Curcumin

Synthesis, characterization, and antiparasitic effects of zinc oxide nanoparticles-eugenol nanosuspension against Toxoplasma gondii infection

Curcumin: Overview of Extraction Methods, Health Benefits, and Encapsulation and Delivery Using Microemulsions and Nanoemulsions

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