Curcumin associated poly(allylamine hydrochloride)-phosphate self-assembled hierarchically ordered nanocapsules: size dependent investigation on release and DPPH scavenging activity of curcumin

Abstract

Curcumin associated poly(allylamine hydrochloride) crosslinks with dipotassium phosphate and silica nanoparticles to form nanocapsule that shows DPPH scavenging activity and releases curcumin triggered by pH.

Improved bioavailability of curcumin in liposomes prepared using a pH-driven, organic solvent-free, easily scalable process

“…1,2 These properties make curcumin suitable as a nutraceutical or pharmaceutical; however, the use of curcumin in food and pharmaceuticals is restricted by its poor water solubility, high susceptibility to degradation and low oral bioavailability. 3 To overcome these problems, curcumin has been incorporated into various carrier systems including nanoparticles, 4 emulsions, 5 halloysite particles, [6][7][8] capsules, 9,10 excipient emulsions, [11][12][13] and liposomes. 14,15 Liposomes are self-assembled spherical vesicles with one or more concentric phospholipid bilayers that encapsulate a fraction of the surrounding aqueous medium.…”

Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury

“…(Patra and Sleem, 2013) have developed a novel method for encapsulation of curcumin by synthesizing microcapsule containing self-assembled nanoparticles using poly (l-lysine), trisodium citrate and silica sol. Mouslmani et al (Mouslmani M, 2015) developed hierarchically ordered nanocapsule structures by crosslinking curcumin associated poly (allylamine hydrochloride) with dipotassium phosphate and subsequently congregates with silica nanoparticles (Mouslmani M, 2015). Excitingly, curcumin loaded in exosomes was not only found more stable, highly soluble and highly concentrated in the blood but also appeared to express more therapeutic potentials (Sun et al, 2010; Zhuang et al, 2011).…”

Redox-sensitive mesoporous silica nanoparticles functionalized with PEG through a disulfide bond linker for potential anticancer drug delivery

“…[7][8] However, the premature release from MSNs, which could cause the serious side effects due to the global distribution, is undesired. [19][20] In addition, It would markedly enhance the specificity and efficacy of the cancer treatment to employ specific novel drugs along with functionalized MSNs. The MSNs, especially functionalized with stimuli responsive materials, could deliver a specific drug to the homologous target site.…”