Curcumin attenuates inflammatory responses by suppressing TLR4-mediated NF-κB signaling pathway in lipopolysaccharide-induced mastitis in mice

The Protective Role of Curcumin in Zymosan-Induced Multiple Organ Dysfunction Syndrome in Mice

“…IL-1b has the ability to increase the level of TNF-a in inflammatory cascades. Previous studies demonstrated that TNF-a, IL-6, and IL-1b may be involved in promoting the local or systemic inflammatory process (24,31,32). In the present study, the level of TNF-a, IL-6, and IL-1b increased significantly in the plasma samples after administration of zymosan compared with treatment group (Fig.…”

“…Another study concluded that curcumin may attenuate the MODS caused by endotoxemia (23). Moreover, a study conducted by Fu et al indicated that curcumin could attenuate inflammatory responses by suppressing TLR4-mediated NF-kB signaling pathway (24). Similarly, inhibition of activation of NF-kB induced by curcumin is mediated by IkBa kinase and ATK, resulting in the suppression of NF-kB dependent gene production (25,26).…”

“…TNF-a is the earliest and primary endogenous mediator of inflammatory reaction (24). IL-6, a pleiotropic cytokine, is produced by monocytes and macrophages and is involved in vascular inflammation and immune reaction.…”

Baicalein attenuates inflammatory responses by suppressing TLR4 mediated NF-κB and MAPK signaling pathways in LPS-induced mastitis in mice

“…Bergenin and salidroside attenuates inflammatory responses by suppressing NF-κB and MAPK signaling pathways [28,29]. Curcumin attenuates inflammatory responses by suppressing TLR4 signaling pathways [30]. Cyaniding-3-O-β-glucoside inhibits inflammatory responses by regulating liver X receptor (LXR) [13].…”

Curcumin prevents diabetic nephropathy against inflammatory response via reversing caveolin-1 Tyr14 phosphorylation influenced TLR4 activation

“…Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is the main active component of turmeric extracted from the roots of the Curcuma longa plant, and has been used for centuries in treating inflammatory ailments and conditions [5][6][7]. But the molecular mechanisms by which curcumin supplementation may inhibit or delay diabetes-associated kidney inflammation and other complications are not known.…”