Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells

Dai, Chongshan; Li, Bin; Zhou, Yan; Li, Daowen; Zhang, Shen; Li, Hui; Xiao, Xilong; Tang, Shusheng

doi:10.1016/j.fct.2016.06.025

Cited by 80 publications

(57 citation statements)

References 54 publications

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“…Induction of CHOP expression is most sensitive to ER stress condition and led to DNA damage [45]. Overexpression of GADD34 can initiate or enhance apoptosis through various signals [47,48]. It has been reported that the pro-apoptotic Bax and the anti-apoptotic Bcl-2 proteins regulate the mitochondrial apoptotic pathway [49,50].…”

Section: Discussionmentioning

confidence: 99%

Polyphenolic Extract of Euphorbia supina Attenuates Manganese-Induced Neurotoxicity by Enhancing Antioxidant Activity through Regulation of ER Stress and ER Stress-Mediated Apoptosis

Bahar

Lee

Bhattarai

et al. 2017

IJMS

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Manganese (Mn) is an important trace element present in human body, which acts as an enzyme co-factor or activator in various metabolic reactions. While essential in trace amounts, excess levels of Mn in human brain can produce neurotoxicity, including idiopathic Parkinson’s disease (PD)-like extrapyramidal manganism symptoms. This study aimed to investigate the protective role of polyphenolic extract of Euphorbia supina (PPEES) on Mn-induced neurotoxicity and the underlying mechanism in human neuroblastoma SKNMC cells and Sprague-Dawley (SD) male rat brain. PPEES possessed significant amount of total phenolic and flavonoid contents. PPEES also showed significant antioxidant activity in 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and reducing power capacity (RPC) assays. Our results showed that Mn treatment significantly reduced cell viability and increased lactate dehydrogenase (LDH) level, which was attenuated by PPEES pretreatment at 100 and 200 µg/mL. Additionally, PPEES pretreatment markedly attenuated Mn-induced antioxidant status alteration by resolving the ROS, MDA and GSH levels and SOD and CAT activities. PPEES pretreatment also significantly attenuated Mn-induced mitochondrial membrane potential (ΔΨm) and apoptosis. Meanwhile, PPEES pretreatment significantly reversed the Mn-induced alteration in the GRP78, GADD34, XBP-1, CHOP, Bcl-2, Bax and caspase-3 activities. Furthermore, administration of PPEES (100 and 200 mg/kg) to Mn exposed rats showed improvement of histopathological alteration in comparison to Mn-treated rats. Moreover, administration of PPEES to Mn exposed rats showed significant reduction of 8-OHdG and Bax immunoreactivity. The results suggest that PPEES treatment reduces Mn-induced oxidative stress and neuronal cell loss in SKNMC cells and in the rat brain. Therefore, PPEES may be considered as potential treat-ment in Mn-intoxicated patients.

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Section: Discussionmentioning

confidence: 99%

Polyphenolic Extract of Euphorbia supina Attenuates Manganese-Induced Neurotoxicity by Enhancing Antioxidant Activity through Regulation of ER Stress and ER Stress-Mediated Apoptosis

Bahar

Lee

Bhattarai

et al. 2017

IJMS

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“…In another study by Dai et al (2016), pre-treatment of L02 cells with curcumin (5 µM) for 2 h resulted in significantly reduced QCT-induced oxidative stress, mitochondrial dysfunction and apoptosis [86]. In addition, inducible nitric oxide synthase (iNOS) mRNA and activity and nitric oxide (NO) production were decreased with curcumin pre-treatment, indicating reduced oxidative stress.…”

Section: Effects Of Curcumin: In Vitro Hepatocyte Studiesmentioning

confidence: 97%

“…In addition, inducible nitric oxide synthase (iNOS) mRNA and activity and nitric oxide (NO) production were decreased with curcumin pre-treatment, indicating reduced oxidative stress. NF-kB mRNA level was reduced, while Nrf2 and heme oxygenase-1 (HO-1) mRNA levels were increased with curcumin treatment, suggesting reduced inflammatory and oxidative injury ( Table 2) [86].…”

Section: Effects Of Curcumin: In Vitro Hepatocyte Studiesmentioning

confidence: 99%

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

2020

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Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by insulin resistance and hyperglycemia. Current preventative and treatment strategies for T2DM and insulin resistance lack in efficacy resulting in the need for new approaches to prevent and manage/treat the disease better. In recent years, epidemiological studies have suggested that diets rich in fruits and vegetables have beneficial health effects including protection against insulin resistance and T2DM. Curcumin, a polyphenol found in turmeric, and curcuminoids have been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, neuroprotective, immunomodulatory and antidiabetic properties. The current review (I of II) summarizes the existing in vitro studies examining the antidiabetic effects of curcumin, while a second (II of II) review summarizes evidence from existing in vivo animal studies and clinical trials focusing on curcumin’s antidiabetic properties.

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“…; Dai et al. ). Significantly, blue light oxidative‐induced toxicity to ARPE19 cells is blunted by both curcumin and red light (Fig.…”

Section: Discussionmentioning

confidence: 98%

Blue light negatively affects the survival of ARPE19 cells through an action on their mitochondria and blunted by red light

Núñez-Álvarez¹,

Suárez-Barrio²,

Olmo-Aguado³

et al. 2018

Acta Ophthalmologica

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Blue light affects mitochondrial function and also the development tight junctions between ARPE19 cells, which results in a loss of cell viability. Importantly, red light delivered after a blue light insult is significantly blunted. These findings argue for the therapeutic use of red light as a noninvasive procedure to attenuate insults caused by blue light and other insults to retinal pigment epithelial cell mitochondria that are likely to occur in age-related macular degeneration.

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Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells

Cited by 80 publications

References 54 publications

Polyphenolic Extract of Euphorbia supina Attenuates Manganese-Induced Neurotoxicity by Enhancing Antioxidant Activity through Regulation of ER Stress and ER Stress-Mediated Apoptosis

Polyphenolic Extract of Euphorbia supina Attenuates Manganese-Induced Neurotoxicity by Enhancing Antioxidant Activity through Regulation of ER Stress and ER Stress-Mediated Apoptosis

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

Blue light negatively affects the survival of ARPE19 cells through an action on their mitochondria and blunted by red light

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