Curcumin Augments Gemcitabine Cytotoxic Effect on Pancreatic Adenocarcinoma Cell Lines

Lev-Ari, Shahar; Vexler, Akiva; Starr, Alexander; Ashkenazy-Voghera, Maia; Greif, Joel; Aderka, Dan; Ben‐Yosef, Rami

doi:10.1080/07357900701359577

Cited by 116 publications

(58 citation statements)

References 38 publications

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“…Studies have shown co-treatments of curcumin and gemcitabine [37], beta-phenylethyl isothiocyanate [38], epigallocatechin gallate [39], and taxol [40] were synergistically cytotoxic to cancer cells. We attempted to examine whether the combinations of curcumin and DNICs also had a synergistic cytotoxic effect against melanoma cells.…”

Section: Cytotoxicity Of Dnics Combined With Curcuminmentioning

confidence: 98%

Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells

Wen

Shiau

et al. 2010

Journal of Organometallic Chemistry

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Section: Cytotoxicity Of Dnics Combined With Curcuminmentioning

confidence: 98%

Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells

Wen

Shiau

et al. 2010

Journal of Organometallic Chemistry

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“…In particular, CUR has demonstrated a potent ability to increase the efficacy of conventional cancer therapies and to chemosensitize cells of colorectal, HNSCC, pancreatic, bladder, and breast tumors [122,123,124,125,126,127,128,129,130]. Shakibadei et al demonstrated that CUR increased the effect of 5-fluorouracil (5-FU) against the colorectal cancer cell lines HCT116 and HCT116+ch3 (complemented with chromosome 3).…”

Section: Combinations Of Polyphenols and Anticancer Drugs: In Vitrmentioning

confidence: 99%

In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment

Fantini

Benvenuto

Masuelli

et al. 2015

IJMS

286

236

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Carcinogenesis is a multistep process triggered by genetic alterations that activate different signal transduction pathways and cause the progressive transformation of a normal cell into a cancer cell. Polyphenols, compounds ubiquitously expressed in plants, have anti-inflammatory, antimicrobial, antiviral, anticancer, and immunomodulatory properties, all of which are beneficial to human health. Due to their ability to modulate the activity of multiple targets involved in carcinogenesis through direct interaction or modulation of gene expression, polyphenols can be employed to inhibit the growth of cancer cells. However, the main problem related to the use of polyphenols as anticancer agents is their poor bioavailability, which might hinder the in vivo effects of the single compound. In fact, polyphenols have a poor absorption and biodistribution, but also a fast metabolism and excretion in the human body. The poor bioavailability of a polyphenol will affect the effective dose delivered to cancer cells. One way to counteract this drawback could be combination treatment with different polyphenols or with polyphenols and other anti-cancer drugs, which can lead to more effective antitumor effects than treatment using only one of the compounds. This report reviews current knowledge on the anticancer effects of combinations of polyphenols or polyphenols and anticancer drugs, with a focus on their ability to modulate multiple signaling transduction pathways involved in cancer.

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“…The enhanced growth inhibition has been found to be associated with significant down-regulation of COX-2 expression under the combination treatment condition. Curcumin also increased the inhibitory effect of gemcitabine on pancreatic cancer cell proliferation, and potentiated pro-apoptotic activity of gemcitabine through the down-regulation of COX-2 and p-ERK1/2 (53). In addition, curcumin analog CDF with higher bioavailability has been synthesized and the effect of CDF on COX-2 expression and pancreatic cancer growth have been tested.…”

Section: Nutraceuticals For Pancreatic Cancer Treatmentmentioning

confidence: 99%

The Role of Nutraceuticals in Pancreatic Cancer Prevention and Therapy

Li¹,

Go²,

Sarkar³

2015

Pancreas

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Pancreatic cancer is one of the most aggressive malignancies in US adults. The experimental studies have found that antioxidant nutrients could reduce oxidative DNA damage, suggesting that these antioxidants may protect against pancreatic carcinogenesis. Several epidemiologic studies showed that dietary intake of antioxidants was inversely associated with the risk of pancreatic cancer, demonstrating the inhibitory effects of antioxidants on pancreatic carcinogenesis. Moreover, nutraceuticals, the anti-cancer agents from diet or natural plants, have been found to inhibit the development and progression of pancreatic cancer through the regulation of cellular signaling pathways. Importantly, nutraceuticals also up-regulate the expression of tumor suppressive miRNAs and down-regulate the expression of oncogenic miRNAs, leading to the inhibition of pancreatic cancer cell growth and pancreatic Cancer Stem Cell (CSC) self-renewal through modulation of cellular signaling network. Furthermore, nutraceuticals also regulate epigenetically deregulated DNAs and miRNAs, leading to the normalization of altered cellular signaling in pancreatic cancer cells. Therefore, nutraceuticals could have much broader use in the prevention and/or treatment of pancreatic cancer in combination with conventional chemotherapeutics. However, more in vitro mechanistic experiments, in vivo animal studies, and clinical trials are needed to realize the true value of nutraceuticals in the prevention and/or treatment of pancreatic cancer.

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Curcumin Augments Gemcitabine Cytotoxic Effect on Pancreatic Adenocarcinoma Cell Lines

Cited by 116 publications

References 38 publications

Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells

Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells

In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment

The Role of Nutraceuticals in Pancreatic Cancer Prevention and Therapy

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