Curcumin-containing liposomes stabilized by thin layers of chitosan derivatives

Karewicz, Anna; Bielska, Dorota; Łoboda, Agnieszka; Gzyl-Malcher, Barbara; Bednář, Jan; Józkowicz, Alicja; Dulak, Józef; Nowakowska, Maria

doi:10.1016/j.colsurfb.2013.03.059

Cited by 115 publications

(67 citation statements)

References 27 publications

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“…Chitosan also explains fungistatic, haemostatic, and antitumor effects [70]. In this regard stable vesicles for efficient curcumin encapsulation, delivery, and controlled release have been obtained by coating of liposomes with thin layer of newly synthesized chitosan derivatives [71]. Some special derivatives of chitosan were studied such as the cationic, hydrophobic, and cationic-hydrophobic derivatives.…”

Section: Chitosansmentioning

confidence: 99%

“…In this regard, the liposomes coated with cationic-hydrophobic chitosan derivatives were the main promising curcumin carriers. They can easily enter cell membrane and release curcumin in a controlled approach, and the biological investigations showed that such organizations are nontoxic for normal murine fibroblasts while toxic for murine melanoma tumors [71]. …”

Section: Chitosansmentioning

confidence: 99%

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Nanotechnology-Applied Curcumin for Different Diseases Therapy

Ghalandarlaki

Alizadeh

Ashkani-Esfahani

2014

BioMed Research International

235

132

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Curcumin is a lipophilic molecule with an active ingredient in the herbal remedy and dietary spice turmeric. It is used by different folks for treatment of many diseases. Recent studies have discussed poor bioavailability of curcumin because of poor absorption, rapid metabolism, and rapid systemic elimination. Nanotechnology is an emerging field that is potentially changing the way we can treat diseases through drug delivery with curcumin. The recent investigations established several approaches to improve the bioavailability, to increase the plasma concentration, and to enhance the cellular permeability processes of curcumin. Several types of nanoparticles have been found to be suitable for the encapsulation or loading of curcumin to improve its therapeutic effects in different diseases. Nanoparticles such as liposomes, polymeric nanoparticles, micelles, nanogels, niosomes, cyclodextrins, dendrimers, silvers, and solid lipids are emerging as one of the useful alternatives that have been shown to deliver therapeutic concentrations of curcumin. This review shows that curcumin's therapeutic effects may increase to some extent in the presence of nanotechnology. The presented board of evidence focuses on the valuable special effects of curcumin on different diseases and candidates it for future clinical studies in the realm of these diseases.

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Section: Chitosansmentioning

confidence: 99%

Section: Chitosansmentioning

confidence: 99%

Nanotechnology-Applied Curcumin for Different Diseases Therapy

Ghalandarlaki

Alizadeh

Ashkani-Esfahani

2014

BioMed Research International

235

132

View full text Add to dashboard Cite

show abstract

“…Liposomes coated with cationic-hydrophobic chitosan can easily penetrate cell membrane and release CUR in a controlled manner [58]. Biological studies indicated that such systems are non-toxic for murine fibroblasts (NIH3T3), while toxic toward murine melanoma (B16F10) cell line [58].…”

Section: Liposomesmentioning

confidence: 99%

“…Biological studies indicated that such systems are non-toxic for murine fibroblasts (NIH3T3), while toxic toward murine melanoma (B16F10) cell line [58]. Similarly, a cationic liposome-PEG-PEI complex (LPPC) was used as a carrier for the encapsulation of CUR to give CUR/ LPPC.…”

Section: Liposomesmentioning

confidence: 99%

Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: current state-of-the-art

Ahmad

Alkahtani

Akhter

et al. 2015

Journal of Drug Targeting

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Comprehensive pharmacological screening of curcumin (CUR) has given the evidence that it is an excellent naturally occurring therapeutic moiety for cancer. It is very well tolerated with insignificant toxicity even after high doses of oral administration. Irrespective of its better quality as an anticancer agent, therapeutic application of CUR is hampered by its extremely low-aqueous solubility and poor bioavailability, rapid clearance and low-cellular uptake. A simple means of breaking up the restrictive factor of CUR is to perk-up its aqueous solubility, improve its bioavailability, protect it from degradation, and metabolism and potentiate its targeting capacity towards the cancer cell. The development in the field of nanomedicine has made excellent progresses toward enhancing the bioavailability of lipophilic drugs like CUR. Nanoparticles (NPs) are capable to deliver the CUR at specific area and thereby prevent it from physiological degradation and systemic clearance. In recent year, an assortment of nanomedicine-based novel drug delivery system has been designed to potentiate the bioavailability of CUR towards anticancer therapy. In this review, we discuss the recent development in the field of nanoCUR (NanoCur), including polymeric micelles, liposome, polymeric NPs, nanoemulsion, nanosuspension, solid lipid NPs (SLNPs), polymer conjugates, nanogel, etc. in anticancer application.

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“…Being highly lipophilic and hence unsuitable for intravenous application, curcumin is a good candidate for incorporation into nanoparticulate drug delivery systems that could make parenteral application feasible (Bansal et al, 2011;Sou, 2012). Curcumin has been formulated in liposomes (Barui et al, 2014;Berginc et al, 2014;Chen et al, 2012;Drakalska et al, 2014;Gosangari and Watkin, 2012;Karewicz et al, 2013;Li et al, 2012;Pandelidou et al, 2011;Tang et al, 2013), nanoemulsions (Ganta and Amiji, 2009), solid lipid nanoparticles (Gota et al, 2010), nanosuspensions (Gao et al, 2010), polymeric nanoparticles Khalil et al, 2013;Misra and Sahoo, 2011), etc.…”

mentioning

confidence: 99%

Curcumin loaded pH-sensitive hybrid lipid/block copolymer nanosized drug delivery systems

Jelezova

Drakalska

Momekova

et al. 2015

European Journal of Pharmaceutical Sciences

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Curcumin is a perspective drug candidate with pleiotropic antineoplastic activity, whose exceptionally low aqueous solubility and poor pharmacokinetic properties have hampered its development beyond the preclinical level. A possible approach to overcome these limitations is the encapsulation of curcumin into nano-carriers, incl. liposomes. The present contribution is focused on feasibility of using hybrid pH-sensitive liposomes, whereby curcumin is entrapped as a free drug and as a water soluble inclusion complex with PEGylated tertbutylcalix[4]arene, which allows the drug to occupy both the phospholipid membranes and the aqueous core of liposomes. The inclusion complexes were encapsulated in dipalmithoylphosphathydilcholine:cholesterol liposomes, whose membranes were grafted with a poly(isoprene-b-acrylic acid) diblock copolymer to confer pH-sensitivity. The liposomes were characterized by DLS, ζ-potential measurements, cryo-TEM, curcumin encapsulation efficacy, loading capacity, and in vitro release as a function of pH. Free and formulated curcumin were further investigated for cytotoxicity, apoptosis-induction and caspase-8, and 9 activation in chemosensitive HL-60 and its resistant sublines HL-60/Dox and HL-60/CDDP. Formulated curcumin was superior cytotoxic and apoptogenic agent vs. the free drug. The mechanistic assay demonstrated that the potent proapoptotic effects of pH-sensitive liposomal curcumin presumably mediated via recruitment of both extrinsic and intrinsic apoptotic pathways in both HL-60 and HL-60/CDDP cells.

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Curcumin-containing liposomes stabilized by thin layers of chitosan derivatives

Cited by 115 publications

References 27 publications

Nanotechnology-Applied Curcumin for Different Diseases Therapy

Nanotechnology-Applied Curcumin for Different Diseases Therapy

Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: current state-of-the-art

Curcumin loaded pH-sensitive hybrid lipid/block copolymer nanosized drug delivery systems

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