Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines

Nakamura, Keiichiro; Yasunaga, Yutaka; Segawa, Tomio; Ko, Daejin; Moul, Judd W.; Srivastava, Shiv; Rhim, Johng S.

doi:10.3892/ijo.21.4.825

Cited by 96 publications

(98 citation statements)

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“…2,3 Recently, curcumin has become a focus of interest with regard to its possible antitumor effects in prostate cancer. [12][13][14][15][16][17][18] This study shows for the first time, to our knowledge, that curcumin exerts an inhibitory effect on the invasiveness of DU-145 prostate cancer cells, and confirms this via both in vitro and in vivo testing.…”

Section: Discussionsupporting

confidence: 76%

“…The results of previous studies have revealed that curcumin exerts pleiotropic effects on prostate cancer cells; however, its functions in invasion and metastasis have yet to be clearly elucidated. [12][13][14][15][16][17][18] Therefore, we assessed the effects of curcumin on the in vitro invasion of prostate cancer cells (DU-145), and further attempted to determine, using a tumor xenograft model, whether curcumin effected an inhibition of prostate cancer cell invasiveness.…”

Section: Introductionmentioning

confidence: 99%

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The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo

Hong

Ahn

Bae

et al. 2006

Prostate Cancer Prostatic Dis

152

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Curcumin has become a focus of interest with regard to its antitumor effects in prostate cancer; however, the effects of this agent on invasion and metastasis remain less well understood. Matrix metalloproteinases (MMPs) are important prerequisite for tumor invasion and metastasis. In this study, we evaluated the effects of curcumin on prostate cancer cells (DU-145) invasion in both in vitro and in vivo. We utilized zymography and ELISA in order to determine the MMP-2 and MMP-9 activity. Matrigel invasion assay was performed to assess cellular invasion. We developed a xenograft model to examine tumorigenicity. Curcumin treatment resulted not only in a significant reduction in the expression of MMP-2 and MMP-9, but also effected the inhibition of invasive ability in vitro. Curcumin was shown to induce a marked reduction of tumor volume, MMP-2, and MMP-9 activity in the tumor-bearing site. The metastatic nodules in vivo were significantly fewer in the curcumintreated group than untreated group. Curcumin appears to constitute a potential agent for the prevention of cancer progression, or at least of the initial phase of metastasis, in prostate cancer.

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo

Hong

Ahn

Bae

et al. 2006

Prostate Cancer Prostatic Dis

152

View full text Add to dashboard Cite

show abstract

“…Recently, it has been reported that curcumin inhibits the expression of AR as well as AR-related cofactors. [21][22][23] In this study, we also showed that curcumin was shown to decrease AR expression, in a dose-dependent manner. However, the molecular mechanism by which curcumin regulates the AR is not completely understood.…”

Section: Discussionsupporting

confidence: 67%

“…19,20 Although the mechanisms associated with curcumin for chemoprevention in prostate cancer have not been fully elucidated, it is conceivable that the effects are on the AR at least in part. [21][22][23] Curcumin has been shown to downregulate the expression of AR and AR-binding activity to the androgen-response element. 21,22 In addition, curcumin inhibits PSA and its analog also acts as an AR antagonist.…”

Section: Introductionmentioning

confidence: 99%

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Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells

Choi

Lim

Hong

2010

Prostate Cancer Prostatic Dis

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Recently, studies have investigated the significance of the Wnt/b-catenin pathway in prostate cancer. The transcriptional activity of the androgen receptor (AR) is modulated by interaction with coregulators, one of which is b-catenin. Curcumin, a dietary yellow pigment of Curcuma longa, has emerged as having a chemopreventive role. Although curcumin has been shown to inhibit AR expression, its molecular mechanism has not been fully elucidated. In this study, whether curcumin mediates the Wnt/b-catenin signaling pathway with regard to AR/b-catenin interactions was studied. Curcumin was shown to induce significant inhibition of AR expression in a dose-dependent manner. Marked curcumin-induced suppression of b-catenin was shown in the nuclear and cytoplasmic extracts as well as whole cell lysates. Further analysis revealed that phosphorylation of Akt and glycogen synthase kinase-3b were attenuated, but phosphorylated b-catenin was increased after curcumin treatment. Finally, cyclin D1 and c-myc, the target gene of the b-catenin/T-cell factor transcriptional complex, were also decreased. These findings suggest that curcumin modulates the Wnt/b-catenin signaling pathway and might have a significant role in mediating inhibitory effects on LNCaP prostate cancer cells.

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Curry spice curcumin and prostate cancer

Kurien¹,

Scofield

2009

Molecular Nutrition Food Res

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Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines

Cited by 96 publications

References 0 publications

The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo

The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo

Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells

Curry spice curcumin and prostate cancer

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