Curcumin down-regulates Ets-1 and Bcl-2 expression in human endometrial carcinoma HEC-1-A cells

Yu, Zhaoning; Shah, Dinesh

doi:10.1016/j.ygyno.2007.05.024

Cited by 47 publications

(21 citation statements)

References 33 publications

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“…Given curcumin's low side-effect profile, it has been evaluated as a therapeutic agent in a wide array of diseases with demonstrated efficacy (20). As a cancer therapy agent, curcumin has molecular function at the transcriptional level (NF-kB, STAT, AP-1, PPAR-g, Egr-1, b-catenin, and Nrf-2 signaling pathways), and has demonstrated efficacy as an inductor of apoptosis in multiple human cancers including skin (45), leukemia (46), colon (47), liver (48), breast (49), lymphoma (50), neuroblastoma (51), pancreatic (52), lung (52), endometrial (53), and ovarian (54). In human leiomyomas, there is evidence of a disruption in apoptosis, resulting in tumor growth (28); and various potential leiomyoma therapies, including gonadotropin-releasing hormone (GnRH) agonists (55), CDB-2914 (56), cetrorelix (57), asoprisnil (58), genestein/TKS050 (59), 2-methoxyestradiol (60), raloxifene (61), and ciglitizone (62), have demonstrated efficacy by regulating apoptosis in leiomyomas.…”

Section: Figurementioning

confidence: 99%

Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression

Malik

Mendoza

Payson

et al. 2009

Fertility and Sterility

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Section: Figurementioning

confidence: 99%

Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression

Malik

Mendoza

Payson

et al. 2009

Fertility and Sterility

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“…Bcl-2 is the most important gene suppressing tumor cell apoptosis [13,14] , which is mapped to chromosome 18. In lymphoma, Bcl-2 is expressed in excess under the control of immunoglobulin heavy chain gene which is translocated to chromosome 14.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of suppression on proliferation of QGY cell by oxaliplatin

Zuo

Zhang

et al. 2007

Chin. J. Cancer Res.

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Objective:To observe the effects of oxaliplatin(L-OHP) on proliferation of human hepatoma cell line QGY in vitro and to investigate the mechanism. Methods: The inhibition of proliferation in QGY cell was assayed by MTT-test. Morphologic changes were observed under light microscope and electronic microscope. Distribution of cell cycle and apoptosis were analyzed using flow cytometry. The expressions of cell cycle proteins and apoptosis-associated proteins were detected with immuno-histochemical technique. Results: Oxaliplatin could inhibit the proliferation of QGY cells and the inhibition depended on the exposure time and dose. The cells showed morphologic changes of the early stage of apoptosis under the light microscope: the shrunk round cells, condensed cytoplasma and pycnosis of nucleus. Apoptotic cells and apoptotic body could be found under the transmission electronic microscope. The analysis of cell cycle indicated that oxaliplatin blocked cells at S and G 2 /M phases and the cells of G 0 /G l phase reduced. When treated with oxaliplatin for 72h, the expressions of cyclin A and Bax were up-regulated, mutant type P53, Bcl-2 and Myc were down-regulated, and Fas was not changed. Conclusion: Oxaliplatin could inhibit the proliferation of the hepatoma cell lines. Cells were blocked at S and G 2 /M phases. The apoptosis was related to the up-regulation of Bax and down-regulation of mutant type P53, Bcl-2 and Myc. Oxaliplatin could not induce apoptosis through the Fas pathway. Key words：Oxaliplatin；Hepatocellular carcinoma；ProliferationOxaliplatin (L-OHP) [chemical name: L-cis-1, 2-diaminocyclohexanemalonato platinum (II)] is one of the third generation platin compounds. Preclinical studies have demonstrated that this drug suppresses many kinds of human and murine tumor cells, and that various cisplatin-resistant tumor cell strains exhibit no cross-resistance to it. Clinical data demonstrate that in the treatment of many kinds of tumors, oxaliplatin, used alone or in combination with other drugs, exhibits good therapeutic effect and tolerance, few toxic or side effects, high chemotherapeutic index, and wide margin ⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯⎯ of safety [1][2][3][4][5][6] . Nevertheless, in vivo and in vitro effects of oxaliplatin in human liver tumor has rarely been reported. In this study, we investigated the effect of oxaliplatin on in vitro proliferation of QGY cells (a human hepatocellular carcinoma (HCC) cell strain) to provide theoretical basis for the clinical treatment of HCC with oxaliplatin. MATERIALS AND METHODS Cell Line and Culture ConditionsQGY cells were provided by the Institute of Hepatitis Viral of the Second Affiliated Hospital, Chongqing University of Medical Sciences. QGY cells were cultured in RPMI1640 medium containing 10% calf serum in air with 5%CO 2 at 37°C.

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“…The transcription factor Ets-1 regulates the expression of factors involved in angiogenesis such as VEGF. Its expression can be inhibited by curcumin in human carcinomas of the endometrium [68]. PMA is an inducer of COX-2 expression.…”

Section: Regulation At the Transcriptional Levelmentioning

confidence: 96%

“…Many compounds modulate the expression of COX-2 by interfering with MAPK signaling pathways. Indeed, phosphorylation of p38 and ERK can be inhibited by curcumin, extracted from the root of Curcuma longa, which has antiinflammatory and anticancer effects [68], by resveratrol, a compound mainly found in red wine and grapes [69] and by epigallocatechin gallate (EGCG) [70], a polyphenol from green tea.…”

Section: Regulation At the Transcriptional Levelmentioning

confidence: 99%

Anti-Inflammatory and Anticancer Drugs from Nature

Orlikova

Legrand

Panning

et al. 2013

Cancer Treatment and Research

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Over the centuries, plant extracts have been used to treat various diseases. Until now, natural products have played an important role in anticancer therapy as there are more than 500 compounds from terrestrial and marine plants or microorganisms, which have antioxidant, antiproliferative, or antiangiogenic properties and are therefore able to reduce tumor growth. The recent discovery of new natural products has been accelerated by novel technologies (high throughput screening of natural products in plants, animals, marine organisms, and microorganisms). Vincristine, irinotecan, etoposide, and paclitaxel are examples of compounds derived from plants that are used in cancer treatment. Similarly, actinomycin D, mitomycin C, bleomycin, doxorubicin, and L-asparaginase are drugs derived from microorganisms. In this review, we describe the molecular mechanisms of natural compounds with anti-inflammatory and anticancer activities.

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Curcumin down-regulates Ets-1 and Bcl-2 expression in human endometrial carcinoma HEC-1-A cells

Cited by 47 publications

References 33 publications

Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression

Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression

Mechanism of suppression on proliferation of QGY cell by oxaliplatin

Anti-Inflammatory and Anticancer Drugs from Nature

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