Curcumin in the treatment of urological cancers: Therapeutic targets, challenges and prospects

Hashemi, Mehrdad; Mirzaei, Sepideh; Barati, Maryamsadat; Hejazi, Elahe Sadat; Kakavand, Amirabbas; Entezari, Maliheh; Salimimoghadam, Shokooh; Kalbasi, Alireza; Rashidi, Mohsen; Taheriazam, Afshin; Sethi, Gautam

doi:10.1016/j.lfs.2022.120984

Cited by 27 publications

(8 citation statements)

References 294 publications

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“…Prostate, renal, and bladder cancer (BCa) are the most common tumors of the urinary system [ 1 ]. Urinary system tumors account for approximately 10% of total tumor incidence, with prostate cancer accounting for 29% of male cancer cases [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The function and mechanisms of action of circular RNAs in Urologic Cancer

et al. 2023

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Kidney, bladder, and prostate cancer are the three major tumor types of the urologic system that seriously threaten human health. Circular RNAs (CircRNAs), special non-coding RNAs with a stabile structure and a unique back-splicing loop-forming ability, have received recent scientific attention. CircRNAs are widely distributed within the body, with important biologic functions such as sponges for microRNAs, as RNA binding proteins, and as templates for regulation of transcription and protein translation. The abnormal expression of circRNAs in vivo is significantly associated with the development of urologic tumors. CircRNAs have now emerged as potential biomarkers for the diagnosis and prognosis of urologic tumors, as well as targets for the development of new therapies. Although we have gained a better understanding of circRNA, there are still many questions to be answered. In this review, we summarize the properties of circRNAs and detail their function, focusing on the effects of circRNA on proliferation, metastasis, apoptosis, metabolism, and drug resistance in kidney, bladder, and prostate cancers.

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Section: Introductionmentioning

confidence: 99%

The function and mechanisms of action of circular RNAs in Urologic Cancer

et al. 2023

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“…Doxorubicin, an important component of combination therapy for muscle‐invasive BC, interferes with cell cycle progression and leads to cancer cell death 49 . Curcumin has a wide range of anticancer activities; it can inhibit the proliferation of BC cells, induce the apoptosis of BC cells, prevent the metastasis of BC cells, promote the antitumor immune response, and enhance the effect of chemotherapeutic drugs when used in combination with chemical drugs 50–52 . However, curcumin has the disadvantage of low bioavailability, and the development of curcumin nanoparticles may significantly improve this problem 53 .…”

Section: Discussionmentioning

confidence: 99%

“…49 Curcumin has a wide range of anticancer activities; it can inhibit the proliferation of BC cells, induce the apoptosis of BC cells, prevent the metastasis of BC cells, promote the antitumor immune response, and enhance the effect of chemotherapeutic drugs when used in combination with chemical drugs. [50][51][52] However, curcumin has the disadvantage of low bioavailability, and the development of curcumin nanoparticles may significantly improve this problem. 53 We found that the mRNA levels of CYP1B1 were reduced after curcumin treatment.…”

Section: F I G U R Ementioning

confidence: 99%

Construction of endothelial cell signatures for predicting the diagnosis, prognosis and immunotherapy response of bladder cancer via machine learning

Fu,

Sun,

Shi

et al. 2024

J Cellular Molecular Medi

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We subtyped bladder cancer (BC) patients based on the expression patterns of endothelial cell (EC) ‐related genes and constructed a diagnostic signature and an endothelial cell prognostic index (ECPI), which are useful for diagnosing BC patients, predicting the prognosis of BC and evaluating drug sensitivity. Differentially expressed genes in ECs were obtained from the Tumour Immune Single‐Cell Hub database. Subsequently, a diagnostic signature, a tumour subtyping system and an ECPI were constructed using data from The Cancer Genome Atlas and Gene Expression Omnibus. Associations between the ECPI and the tumour microenvironment, drug sensitivity and biofunctions were assessed. The hub genes in the ECPI were identified as drug candidates by molecular docking. Subtype identification indicated that high EC levels were associated with a worse prognosis and immunosuppressive effect. The diagnostic signature and ECPI were used to effectively diagnose BC and accurately assess the prognosis of BC and drug sensitivity among patients. Three hub genes in the ECPI were extracted, and the three genes had the closest affinity for doxorubicin and curcumin. There was a close relationship between EC and BC. EC‐related genes can help clinicians diagnose BC, predict the prognosis of BC and select effective drugs.

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“…Xie et al [ 503 ] reported that curcumin together with photodynamic therapy have been confirmed as effective in many kinds of cancer cells in vitro and animal models. It has been extensively applied in cancer treatment because of its ability to trigger cell death and suppress metastasis [ 504 ]. Mahjoob and Stochaj [ 505 ] reported that curcumin improves aging-related cellular and organ dysfunctions.…”

Section: The Health Benefits Of Curcuminoids (Curcumin Demethoxycurcu...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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Curcumin in the treatment of urological cancers: Therapeutic targets, challenges and prospects

Cited by 27 publications

References 294 publications

The function and mechanisms of action of circular RNAs in Urologic Cancer

The function and mechanisms of action of circular RNAs in Urologic Cancer

Construction of endothelial cell signatures for predicting the diagnosis, prognosis and immunotherapy response of bladder cancer via machine learning

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

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