Curcumin increased the differentiation rate of neurons in neural stem cells via wnt signaling in vitro study

Chen, Fei; Wang, Hao-Xiang; Xiang, Xin; Yuan, Jingkun; Chu, Weihua; Xue, Xingsen; Zhu, Haitao; Ge, Hongfei; Zou, Mingming; Feng, Hua; Lin, Jiangkai

doi:10.1016/j.jss.2014.06.026

Cited by 44 publications

(30 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CUR might be a good agent for preventing intervention, reducing the episode relapse and the oxidative stress associated with the manic phase of BD. Chen et al 37 demonstrated the relationship between the neuroprotective effects of CUR and the classical wnt signaling pathway using Spragueee-Dawley rats. Neural stem cells from the anterior two-third of the fetal rat brain were passage three times using the half media replacement method and identified using cellular immunofluorescence.…”

Section: Biological Activities Of Curcuminoidsmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

730

413

View full text Add to dashboard Cite

In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis. Different clinical trials also suggest a potential therapeutic role for curcuminoids in numerous chronic diseases such as colon cancer, lung cancer, breast cancer, inflammatory bowel diseases. The aim of this review is to summarize the chemistry, analog, metal complex, formulations of curcuminoids and their biological activities.

show abstract

Section: Biological Activities Of Curcuminoidsmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

730

413

View full text Add to dashboard Cite

show abstract

“…In vitro studies have shown that 0.5 μM curcumin increases the differentiation rate of neurons in neural stem cells via Wnt signaling pathway (132). It’s also reported curcumin can enhance EB directed differentiation of H-9 human embryonic stem cells (hESCs).…”

Section: The Importance Of Dose In the In Vitro And In Vivo Chemoprevmentioning

confidence: 99%

In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

Ramirez

Zhang

et al. 2017

AAPS J

View full text Add to dashboard Cite

According to the National Center of Health Statistics, cancer was the culprit of nearly 600,000 deaths in 2016 in the United States. It is by far one of the most heterogeneous diseases to treat. Treatment for metastasized cancers remains a challenge despite modern diagnostics and treatment regimens. For this reason, alternative approaches are needed. Chemoprevention using dietary phytochemicals such as triterpenoids, isothiocyanates, and curcumin in the prevention of initiation and/or progression of cancer poses a promising alternative strategy. However, significant challenges exist in the extrapolation of in vitro cell culture data to in vivo efficacy to animal models and particularly to human. In this review, the dose at which these phytochemicals elicit a response in vitro and in vivo of a multitude of cellular signaling pathways will be reviewed highlighting Nrf2-mediated anti-oxidative stress, anti-inflammation, epigenetics, cytoprotection, differentiation, and growth inhibition. The in vitro-in vivo dose response of phytochemicals can vary due in part to the cell line/animal model used, the assay system of the biomarker used for the readout, chemical structure of the functional analog of the phytochemical, and the source of compounds used for the treatment study. While the dose response varies across different experimental designs, the chemopreventive efficacy appears to remain and demonstrates the therapeutic potential of triterpenoids, isothiocyanates, and curcumin in cancer prevention and in health in general.

show abstract

“…A number of studies showed that curcumin or its loaded nanoparticles promote proliferation and differentiation of adult-born neurons in the dentate gyrus of both normal and diseased mice (Xu et al, 2007;Kim et al, 2008;Dong et al, 2012;Tiwari et al, 2014). However, controversial findings have been obtained on the ability of curcumin in promoting neuronal differentiation of embryonic stem cells (Yanes et al, 2010;Chen et al, 2014). Furthermore, curcumin was shown to induce neuritogenesis in neuroblastoma cells or culture neurons at doses between 10-20 lM, which is $20 times high than its optimal concentration to promote neural progenitor proliferation (Kim et al, 2008;Liao et al, 2012;Lu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

A natural diarylheptanoid promotes neuronal differentiation via activating ERK and PI3K-Akt dependent pathways

et al. 2015

View full text Add to dashboard Cite

Curcumin increased the differentiation rate of neurons in neural stem cells via wnt signaling in vitro study

Cited by 44 publications

References 20 publications

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

A natural diarylheptanoid promotes neuronal differentiation via activating ERK and PI3K-Akt dependent pathways

Contact Info

Product

Resources

About