Curcumin induces a nuclear factor-erythroid 2-related factor 2-driven response against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters

Charoensuk, Lakhanawan; Pinlaor, Porntip; Prakobwong, Suksanti; Hiraku, Yusuke; Laothong, Umawadee; Ruangjirachuporn, Wipaporn; Yongvanit, Puangrat; Pinlaor, Somchai

doi:10.1016/j.ijpara.2010.12.011

Cited by 48 publications

(27 citation statements)

References 36 publications

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“…Therefore, the cycle is perpetuated. Previous studied found that the past use of praziquantel associated with OV infection (Saengsawang et al, 2013) and in hamsters infected with ov reported repeated infection and drug treatment can increase the risk of CCA (Charoensuk et al, 2011). Contrast with study of supot kamsa-ard et al (2013) found that praziquantel treatment and CCA was not statistical significant with a pooled OR of 1.8 (95%CI; 0.81 to 4.16).…”

Section: Introductionmentioning

confidence: 89%

Prevalence and Risk Factors for Opisthorchis viverrini Infections in Upper Northeast Thailand

Thaewnongiew¹,

Singthong²,

Kutchamart³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Opisthorchis viverrini is an ongoing public health problem in Northeast Thailand. Despite continuous efforts for decades by healthcare organizations to overcome this problem, infection rates remain high. To enable related personnel to identify and address the various issues effectively, a cross-sectional study was performed to investigate prevalence and risk factors for opisthorchiasis. The target group was 3,916 Thai residents of Northeast Thailand who were 15 or over. Participants were recruited using the 30 clusters sampling technique. The data were gathered through questionnaires, focus group discussions, in-depth interviews, and stool examinations for parasite eggs (using the Modified Kato Katz method). The data were analyzed using descriptive and inference statistics; in order to ascertain the risk factors and test them using the odds ratio and multiple logistic regressions. The prevalence of opisthorchiasis was 22.7% (95%CI: 0.26 to 0.24). The province with the highest prevalence was Nakhorn Phanom (40.9%; female to male ratio =1:1.2). The age group with the highest prevalence was 40-49 year olds. All age groups had a prevalence >20%. Four of seven provinces had a prevalence >20%. The factors related to opisthorchiasis were (a) sex, (b) age (especially > 50), (c) proximity and duration living near a water body, and (d) eating raw and/or fermented fish. In order to reduce the prevalence of opisthorchiasis, the focus in populations living in upper Northeast Thailand should be changing their eating behaviors as appropriate to their tradition and context.

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Section: Introductionmentioning

confidence: 89%

Prevalence and Risk Factors for Opisthorchis viverrini Infections in Upper Northeast Thailand

Thaewnongiew¹,

Singthong²,

Kutchamart³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Current therapies for age-related degenerative diseases have been jeopardized owing to several setbacks in DNA and/or protein delivery. Curcumin is a pharmacologically safe agent 10, 11 with many activities including a powerful antioxidant function and anti-inflammatory properties. 12, 13 This agent has been found to induce expression of the antioxidant enzymes in various cell types.…”

mentioning

confidence: 99%

“…14, 15, 16 Curcumin mediates its effects by modulating several important molecular targets, including transcription factors NF- κ B, Ap1 and specificity protein 1 (Sp1). 15, 17, 18, 19 Recently, curcumin has been shown to suppress NF- κ B activation 10, 14 and activate the transcription factor Sp1. Sp1 is a stress-inducible, antideath transcriptional factor with a wide spectrum of beneficial activity, which it exerts by binding to a GC-rich element (or GC-box) in the promoter of target genes.…”

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confidence: 99%

Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress

et al. 2011

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Peroxiredoxin 6 (Prdx6) is a pleiotropic oxidative stress-response protein that defends cells against reactive oxygen species (ROS)-induced damage. Curcumin, a naturally occurring agent, has diversified beneficial roles including cytoprotection. Using human lens epithelial cells (hLECs) and Prdx6-deficient cells, we show the evidence that curcumin protects cells by upregulating Prdx6 transcription via invoking specificity protein 1 (Sp1) activity against proapoptotic stimuli. Curcumin enhanced Sp1 and Prdx6 mRNA and protein expression in a concentration-dependent manner, as evidenced by western and real-time PCR analyses, and thereby negatively regulated ROS-mediated apoptosis by blunting ROS expression and lipid peroxidation. Bioinformatic analysis and DNA–protein binding assays disclosed three active Sp1 sites (−19/27, −61/69 and −82/89) in Prdx6 promoter. Co-transfection experiments with Sp1 and Prdx6 promoter–chloramphenicol acetyltransferase (CAT) constructs showed that CAT activity was dramatically increased in LECs or Sp1-deficient cells (SL2). Curcumin treatment of LECs enhanced Sp1 binding to its sites, consistent with curcumin-dependent stimulation of Prdx6 promoter with Sp1 sites and cytoprotection. Notably, disruption of Sp1 sites by point mutagenesis abolished curcumin transactivation of Prdx6. Also, curcumin failed to activate Prdx6 expression in the presence of Sp1 inhibitors, demonstrating that curcumin-mediated increased expression of Prdx6 was dependent on Sp1 activity. Collectively, the study may provide a foundation for developing transcription-based inductive therapy to reinforce endogenous antioxidant defense by using dietary supplements.

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“…144 A recent study demonstrated that curcumin may exert chemopreventative potential in cases of oxidative/nitrative stress following praziquantel treatment of liver fluke infections. 145 Curcumin administered to Opisthorchis viverrini-infected, praziquantel-treated hamsters significantly decreased eosinophil infiltration; increased mononuclear cell infiltration; increased transcriptional and translational expression of Nrf2, Nrf2-regulated stress pathway genes, and HO-1; increased the ferric antioxidant activity of the plasma; decreased oxidative/nitrative stress markers; and suppressed NF-κB activity. 145 Interestingly, a study investigating the antioxidant effects of curcumin discovered that the compound potentiated doxorubicin toxicity towards normal cardiac muscle cells by stimulating doxorubicin-mediated ROS production and modulating the expression of anti-and pro-apoptotic proteins in favor of apoptosis induction.…”

Section: Toxicologymentioning

confidence: 95%

Pharmacological and clinical properties of curcumin

Beevers¹,

Huang

2011

BTAT

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The polyphenol natural product curcumin has been the subject of numerous studies over the past decades, which have identified and characterized the compound's pharmacokinetic, pharmacodynamic, and clinical pharmacological properties. In in vitro and in vivo model systems, curcumin displays potent pharmacological effects, by targeting many critical cellular factors, through a diverse array of mechanisms of action. Despite this tremendous molecular versatility, however, the clinical application of curcumin remains limited due to poor pharmacokinetic characteristics in human beings. The current trend is to develop and utilize unique delivery systems, chemical derivatives, and chemical analogs to circumvent these pharmacological obstacles, in order to optimize the conditions for curcumin as a chemopreventive and chemotherapeutic agent in diseases such as cancer, diabetes, obesity, Alzheimer's disease, and inflammatory disorders. The present work seeks to review recent studies in the basic pharmacological principles and potential clinical applications of curcumin.

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Curcumin induces a nuclear factor-erythroid 2-related factor 2-driven response against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters

Cited by 48 publications

References 36 publications

Prevalence and Risk Factors for Opisthorchis viverrini Infections in Upper Northeast Thailand

Prevalence and Risk Factors for Opisthorchis viverrini Infections in Upper Northeast Thailand

Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress

Pharmacological and clinical properties of curcumin

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