Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling

Du, Yifan; Long, Qi; Zhang, Lin; Shi, Ying; Liu, Xioagang; Li, Xudong; Guan, Bin; Tian, Yanchao; Wang, Xinyang; Li, Lei; He, Dalin

doi:10.3892/ijo.2015.3202

Cited by 98 publications

(74 citation statements)

References 61 publications

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“…We and others have previously demonstrated that CAF‐induced EMT is dependent on a proinflammatory signaling leading to HIF1α stabilization in normoxic condition (Du et al, ; Gandellini et al, ; Giannoni et al, ; Luo et al, ). By an, in silico analysis of miR‐1247 promoter we highlighted the existence of three hypoxia responsive elements and three HIF1α ancillary sequence binding site (Supporting Information Figure 1a).…”

Section: Resultsmentioning

confidence: 88%

Stromal‐induced downregulation of miR‐1247 promotes prostate cancer malignancy

Taddei

Cavallini

Ramazzotti

et al. 2018

Journal Cellular Physiology

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Cancer progression is strictly dependent on the relationship between tumor cells and the surrounding stroma, which supports cancer malignancy promoting several crucial steps of tumor progression, including the execution of the epithelial to mesenchymal transition (EMT) associated with enhancement in cell invasion, resistance to both anoikis and chemotherapeutic treatments. Recently it has been highlighted the central role of microRNAs (miRNAs) as regulators of tumor progression. Notably, in several tumors a strong deregulation of miRNAs is observed, supporting proliferation, invasion, and metabolic reprogramming of tumor cells. Here we demonstrated that cancer‐associated fibroblasts induce a downregulation of miR‐1247 in prostate cancer (PCa) cells. We proved that miR‐1247 repression is functional for the achievement of EMT and increased cell invasion as well as stemness traits. These phenomena contribute to promote the metastatic potential of PCa cells as demonstrated by increased lung colonization in in vivo experiments. Moreover, as a consequence of miR‐1247 downregulation, we observed a correlated increased expression level of neuropilin‐1, a miR‐1247 target involved as a coreceptor in the epidermal growth factor receptor signaling. Taken together, our data highlight miR‐1247 as a potential target for molecular therapies aimed to block the progression and diffusion of PCa.

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Section: Resultsmentioning

confidence: 88%

Stromal‐induced downregulation of miR‐1247 promotes prostate cancer malignancy

Taddei

Cavallini

Ramazzotti

et al. 2018

Journal Cellular Physiology

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“…IL-6 is expressed principally in T cells, fibroblast, macrophages, and mast cells; however, it could also be detected interacting with its receptor in prostatic cells [18]. Miličević et al in 2015 showed that IL-6 is expressed in epithelial and basal prostatic cells from normal, prostatic, and BPH and in premalignant and malignant epithelial cells as well as in some stromal cells [19].…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Effect of Dialyzable Leukocyte Extract in Autoimmune Prostatitis: Evaluation in Animal Model

Pérez-Alvarado

Gómez

Reyes

et al. 2017

BioMed Research International

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Objective. To evaluate the anti-inflammatory properties of Dialyzable Leukocyte Extract (DLE) in a murine model of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Methods. Histopathological characterization, prostatein Enzyme-Linked Immunosorbent Assay, and immunohistochemical analysis for CD45, TNF-α, IFN-γ, IL-6, IL-17, and IL-4 molecules were done in prostatic Wistar rats treated with DLE, placebo, or Dexamethasone. Results. Histopathological analysis of animals induced to prostatitis showed inflammatory infiltrate, mainly constituted by leucocytes and mast cells as well as Benign Prostatic Hyperplasia. Serum prostatein concentrations were 14 times higher than those displayed by healthy animals. After DLE and Dexamethasone treatments, the inflammatory infiltrate decreased; the tissue morphology was similar to that of a normal prostate, and the prostatein decreased to the basal levels of healthy animals. DLE treatment produced a decreased expression of the cell surface marker CD45 and the proinflammatory cytokines TNF-α, IFN-γ, IL-6, and IL-17. On the other hand, the expression of anti-inflammatory cytokine IL-4 increased in both the Dexamethasone and DLE groups. Conclusion. DLE is able to modulate the inflammatory response in Experimental Autoimmune Prostatitis (EAP).

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“…Moreover, the signals resulting from the downstream of this interconnection can lead to the self‐renewal of cancer cells and make them resistant to apoptosis by activating the anti‐apoptotic PI3K/AKT pathway . Additionally, the signals resulting from this interaction can increase the expression of HIF and activate the matrix metalloproteinases (MMP), which altogether enhance angiogenesis and the movement of cancer cells from their origin to other sites . In general, CXCR4 and CXCL12 factors in cancer patients can be used as diagnostic markers to evaluate the differentiation rate of MSC‐derived CAF cells (Figure ).…”

Section: The Role Of Chemokines In Pre‐metastatic and Metastatic Nichesmentioning

confidence: 99%

Role of chemokines in metastatic niche: new insights along with a diagnostic and prognostic approach

Rezaeeyan

Shirzad

McKee

et al. 2018

APMIS

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Chemokines are cytokines that are involved in the movement of leukocytes and the occurrence of immune responses. It has recently been noted that these cytokines play a role in the movement of cancer cells to different parts of the body and create a suitable environment [i.e. (pre) metastatic niche] for their growth and proliferation. We studied the role of chemokines in the metastasis of cancer cells, as well as their involvement in the proliferation and growth of these cells. Relevant literature was identified by a PubMed search (2005-2017) of English language papers using the terms 'chemokine,' 'metastasis niche,' and 'organotropism.' Based on the nature of cancer cells, the expression of chemokine receptors on these cells leads to metastasis to various organs, which ultimately causes changes in different signaling pathways. Finally, the targeting of chemokines on cancer cells could prevent the metastasis of cancer cells toward different organs.

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Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling

Cited by 98 publications

References 61 publications

Stromal‐induced downregulation of miR‐1247 promotes prostate cancer malignancy

Stromal‐induced downregulation of miR‐1247 promotes prostate cancer malignancy

Anti-Inflammatory Effect of Dialyzable Leukocyte Extract in Autoimmune Prostatitis: Evaluation in Animal Model

Role of chemokines in metastatic niche: new insights along with a diagnostic and prognostic approach

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