Curcumin loaded Ag–TiO<sub>2</sub>-halloysite nanotubes platform for combined chemo-photodynamic therapy treatment of cancer cells

Nyankson, Emmanuel; Awuzah, Dominic; Tiburu, Elvis K.; Efavi, Johnson Kwame; Agyei‐Tuffour, Benjamin; Paemka, Lily

doi:10.1039/d2ra05777h

Cited by 13 publications

(3 citation statements)

References 63 publications

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“…For these tests, we used the 1:1 resveratrol/HNTs–kojic acid and 1:100 curcumin/HNTs–kojic acid loading ratios to appreciate the drugs’ release better. Consistent with the literature [ 30 , 35 , 49 , 50 ], up to 10 h, the release kinetics was relatively fast (about 40% for the resveratrol and 20% for the curcumin), after which the release became slower, with a waiver of 50% and about 30% in 20 h for the resveratrol and the curcumin, respectively, to reach 60% for the resveratrol and the 45% for the curcumin at 40 h. The latter drug was characterized by a slower kinetics compared to resveratrol. The quick drug release in the first hours was due to the rapid dissolution of the drugs adsorbed in the nanotubes of the halloysite, while the other drug molecules were gradually released from the sample surface, and this delivery was also affected by the diffusion phenomena.…”

Section: Resultssupporting

confidence: 91%

Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity

et al. 2023

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Bacterial involvement in cancer’s development, along with their impact on therapeutic interventions, has been increasingly recognized. This has prompted the development of novel strategies to disrupt essential biological processes in microbial cells. Among these approaches, metal-chelating agents have gained attention for their ability to hinder microbial metal metabolism and impede critical reactions. Nanotechnology has also contributed to the antibacterial field by offering various nanomaterials, including antimicrobial nanoparticles with potential therapeutic and drug-delivery applications. Halloysite nanotubes (HNTs) are naturally occurring tubular clay nanomaterials composed of aluminosilicate kaolin sheets rolled multiple times. The aluminum and siloxane groups on the surface of HNTs enable hydrogen bonding with biomaterials, making them versatile in various domains, such as environmental sciences, wastewater treatment, nanoelectronics, catalytic studies, and cosmetics. This study aimed to create an antibacterial material by combining the unique properties of halloysite nanotubes with the iron-chelating capability of kojic acid. A nucleophilic substitution reaction involving the hydroxyl groups on the nanotubes’ surface was employed to functionalize the material using kojic acid. The resulting material was characterized using infrared spectroscopy (IR), thermogravimetric analysis (TGA), energy-dispersive X-ray spectroscopy (EDX), and scanning electron microscopy (SEM), and its iron-chelating ability was assessed. Furthermore, the potential for drug loading—specifically, with resveratrol and curcumin—was evaluated through ultraviolet (UV) analysis. The antibacterial assay was evaluated following CLSI guidelines. The results suggested that the HNTs–kojic acid formulation had great antibacterial activity against all tested pathogens. The outcome of this work yielded a novel bio-based material with dual functionality as a drug carrier and an antimicrobial agent. This innovative approach holds promise for addressing challenges related to bacterial infections, antibiotic resistance, and the development of advanced therapeutic interventions.

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Section: Resultssupporting

confidence: 91%

Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity

et al. 2023

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“…Nyankson [54] CUR Synergistic anticancer effect of curcumin and Ag-TiO 2 based phototherapy; Controlled release.…”

Section: Cervical Cancer Helamentioning

confidence: 99%

“…Nyankson's exploration delved into the realm of curcumin‐Ag‐TiO 2 ‐HNT composites, [ 54 ] which sought to exploit the synergistic anticancer effects that emerge from the interplay of chemo‐ and photothermal therapies. While providing limited insight into the composite's anticancer effect and biocompatibility, this study nonetheless casts a promising light on the potential of HNT‐based composites to usher in targeted and personalized paradigms within cancer therapy.…”

Section: Halloysite Nanotubes In Cancer Treatmentmentioning

confidence: 99%

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Jiang,

Sun,

Liu

et al. 2023

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Halloysite nanotubes (HNTs) have emerged as a highly regarded choice in biomedical research due to their exceptional attributes, including superior loading capacity, customizable surface characteristics, and excellent biocompatibility. HNTs feature tubular structures comprising alumina and silica layers, endowing them with a large surface area and versatile surface chemistries that facilitate selective modifications. Moreover, their substantial pore volume and wide range of pore sizes enable efficient entrapment of diverse functional molecules. This comprehensive review highlights the broad biomedical application spectrum of HNTs, shedding light on their potential as innovative and effective therapeutic agents across various diseases. It emphasizes the necessity of optimizing drug delivery techniques, developing targeted delivery systems, rigorously evaluating biocompatibility and safety through preclinical and clinical investigations, exploring combination therapies, and advancing scientific understanding. With further advancements, HNTs hold the promise to revolutionize the pharmaceutical industry, opening new avenues for the development of transformative treatments.

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Confinement of Lauric Acid into the Lumen of Halloysite Nanotubes

Obele,

Barroso‐Bujans

2024

Part & Part Syst Charact

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Molecules confined within nanometer‐scale environments frequently exhibit a distinct physical response in contrast to those found in bulk conditions. In this study, intercalates of lauric acid (LA) are synthesized within halloysite nanotubes (HNT), successfully trapping 12 wt.% of LA within the internal HNT tube, as demonstrated by transmission electron microscopy (TEM), and wide‐angle and small‐angle X‐ray scattering (WAXS/SAXS) techniques. Furthermore, it is noted that the confinement of LA within the HNT lumen resulted in a significant reduction in LA crystallinity, consistent with the impact of geometric constraints on crystallization behavior. The presence of a significant amorphous phase in the intercalates proved beneficial for the gradual release of LA into water, as evidenced by pH changes. Remarkably, the necessity of employing a vacuum method and extended contact time (72 h) for the physical entrapment of LA in ethanol within the HNT lumen is found to be unnecessary, as similar physical characteristics are observed in an intercalate generated without vacuum and with very short contact time (<1 h). Finally, it is observed that the source of HNT is crucial in determining the final properties of the confined material.

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Curcumin loaded Ag–TiO₂-halloysite nanotubes platform for combined chemo-photodynamic therapy treatment of cancer cells

Abstract: The synergy between photogenerated reactive oxygen species and the anticancer potency of curcumin was examined by exposing HeLa cancer cells to irradiated curcumin loaded halloysite nanotubes-Ag–TiO2 nanomaterial. 0% cell viability was obtained.

Cited by 13 publications

References 63 publications

Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity

Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Confinement of Lauric Acid into the Lumen of Halloysite Nanotubes

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Curcumin loaded Ag–TiO2-halloysite nanotubes platform for combined chemo-photodynamic therapy treatment of cancer cells

Abstract: The synergy between photogenerated reactive oxygen species and the anticancer potency of curcumin was examined by exposing HeLa cancer cells to irradiated curcumin loaded halloysite nanotubes-Ag–TiO2 nanomaterial. 0% cell viability was obtained.

Cited by 13 publications

References 63 publications

Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity

Total Bio-Based Material for Drug Delivery and Iron Chelation to Fight Cancer through Antimicrobial Activity

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Confinement of Lauric Acid into the Lumen of Halloysite Nanotubes

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Curcumin loaded Ag–TiO₂-halloysite nanotubes platform for combined chemo-photodynamic therapy treatment of cancer cells