Curcumin-loaded biocompatible thermoresponsive polymeric nanoparticles for cancer drug delivery

Rejinold, N. Sanoj; Muthunarayanan, M.; Divyarani, V.V.; Sreerekha, P.R.; Chennazhi, K.P.; Nair, Shantikumar V.; Tamura, Hiroshi; Jayakumar, R.

doi:10.1016/j.jcis.2011.04.006

Cited by 231 publications

(126 citation statements)

References 22 publications

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“…최근에는 메밀, 작약근, 장미꽃, 콩나물 자엽, 정향, 백자인, 녹차, 강황(심황, 울금), 검정콩 종피, 도라지 (길경), 동백 꽃잎 추출물 등과 같은 유용성 천연유래 항균 물질(Antimicrobial)을 전달체(Delivery System)에 담아 생리활성 및 효능을 극대화하기 위하여 나노크기 (Nano-Size)의 전달체를 만들려는 연구가 활발히 진행 되고 있다 [12][13][14][15][16][17][18][19][20][21]. 일반적으로 항균력이 높은 물질들은 피부에 자극을 주어 알레르기(Allergy)나 염증을 유발 하는 성분을 포함하고 있는 경우가 많기 때문에, 이러 한 유용성 항균 물질의 보호 및 저장 안정성 향상을 위하여 캡슐화(Encapsulation)하는 것이 가장 일반적인 방법으로 알려져 있으며 [22][23], 항균 물질을 캡슐화 함으로서 물리적 장벽을 제공해 주어 외부 환경으로부 터 보호하고 피부에 직접 닿을 시에도 자극과 독성을 감소시키거나 없앨 수 있다 [22,24].…”

Section: 서 론unclassified

Preparation of Hydrophobic Antimicrobal Compounds Encapsulated Nanoparticles Using Alkoxysilane-functionalized Amphiphilic Polymer Precursor and Their Antimicrobial Properties

Kim¹,

Kim²

2017

Adhesion and Interface

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In this study, nanoparticles which encapsulated hydrophobic antimicrobial compounds with 50wt% of payload and 70%of solid content were prepared. These nanoparticles could be dispersed at water as well as various medium. Water dispersible organic-inorganic (O-I) hybrid nanoparticles were first prepared using alkoxysilane-functionalized amphiphilic polymer precursors through a conventional sol-gel process. Hydrophobic antimicrobial compound, Eugenol encapsulated nanoparticles were prepared using these O-I hybrid nanoparticles through a new nanoprecipitation process. The effect of various preparation on the size of nanoparticles, amount of payload, antimicrobial activity, and release rate of encapsulated compounds was investigated. All eugenol-encapsulated O-I nanoparticles regardless of preparation condition showed the same minimal inhibitory concentration (MIC) (50mg/ml) and 99% of antimicrobial activity for every strain. Their antimicrobial activity could maintain longer than two weeks. Especially, eugenol-encapsulated O-I nanoparticles prepared using tetraethoxysilane (TEOS) exhibited the highest payload (50wt%) and the lowest release rate which was owing to higher inorganic content in the O-I nanoparticles. And these O-I nanoparticles dispersed in hexanediol (HD) showed the highest antimicrobial activity and solid content (70wt%) because HD acted as a solvent as well as a antimicrobial agent.

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Section: 서 론unclassified

Preparation of Hydrophobic Antimicrobal Compounds Encapsulated Nanoparticles Using Alkoxysilane-functionalized Amphiphilic Polymer Precursor and Their Antimicrobial Properties

Kim¹,

Kim²

2017

Adhesion and Interface

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“…Furthermore, serum stability and intratumoral accumulation were significantly improved (Li et al, 2012). Rejinold et al (2011) designed a highly stable curcuminloaded thermosensitive NP drug delivery system based on chitosan-g-poly(N-vinylcaprolactam) (TRC-Nps), which showed preferential cytotoxicity toward cancerous cells and seemed to be more beneficial when combined with hyperthermia. Gong et al (2009a) introduced a thermosensitive polyethylene glycol-poly("-caprolactone)-polyethylene glycol (PEG-PCL-PEG, PECE) hydrogel, which remains in the soluble phase at low temperatures (10 C) but forms a gel at body temperature upon injection.…”

Section: Thermosensitive Polymersmentioning

confidence: 99%

Classification of stimuli–responsive polymers as anticancer drug delivery systems

et al. 2014

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Although several anticancer drugs have been introduced as chemotherapeutic agents, the effective treatment of cancer remains a challenge. Major limitations in the application of anticancer drugs include their nonspecificity, wide biodistribution, short half-life, low concentration in tumor tissue and systemic toxicity. Drug delivery to the tumor site has become feasible in recent years, and recent advances in the development of new drug delivery systems for controlled drug release in tumor tissues with reduced side effects show great promise. In this field, the use of biodegradable polymers as drug carriers has attracted the most attention. However, drug release is still difficult to control even when a polymeric drug carrier is used. The design of pharmaceutical polymers that respond to external stimuli (known as stimuli-responsive polymers) such as temperature, pH, electric or magnetic field, enzymes, ultrasound waves, etc. appears to be a successful approach. In these systems, drug release is triggered by different stimuli. The purpose of this review is to summarize different types of polymeric drug carriers and stimuli, in addition to the combination use of stimuli in order to achieve a better controlled drug release, and it discusses their potential strengths and applications. A survey of the recent literature on various stimuli-responsive drug delivery systems is also provided and perspectives on possible future developments in controlled drug release at tumor site have been discussed.

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“…For instance, 5-flourouracil-loaded chitosan-g-PNVCL nanoparticles [88], gliclazide-loaded chitosan microparticles [89], rifampicin-and hydroxyurea-loaded chitosan microspheres [90], and exotoxin-chitosan microparticles obtained by spray drying were developed using TPP as a cross-linker [91].…”

Section: Pentasodium Tripolyphosphatementioning

confidence: 99%

“…Nanoparticles showed an excellent hemocompatibility after 4 h of incubation with erythrocytes, thus suggesting that intravenous administration of these formulations may be possible. In addition, it has been reported that the modified chitosan may be useful for both hydrophobic [88] and hydrophilic drug encapsulation [45] via a thermosensitive drug release mechanism. Also, nanoparticles produced with chitosan modified with PNIPAAm-COOH (chitosan-g-PNIPAAm) were developed for the delivery of curcumin [127].…”

Section: Nanoparticles Produced With Chitosan-grafted Thermosensitivementioning

confidence: 99%

Approaches for Functional Modification or Cross‐Linking of Chitosan

Anitha

Rejinold

Bumgardner

et al. 2012

Chitosan‐Based Systems for Biopharmaceuticals

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Curcumin-loaded biocompatible thermoresponsive polymeric nanoparticles for cancer drug delivery

Cited by 231 publications

References 22 publications

Preparation of Hydrophobic Antimicrobal Compounds Encapsulated Nanoparticles Using Alkoxysilane-functionalized Amphiphilic Polymer Precursor and Their Antimicrobial Properties

Preparation of Hydrophobic Antimicrobal Compounds Encapsulated Nanoparticles Using Alkoxysilane-functionalized Amphiphilic Polymer Precursor and Their Antimicrobial Properties

Classification of stimuli–responsive polymers as anticancer drug delivery systems

Approaches for Functional Modification or Cross‐Linking of Chitosan

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