Curcumin Loaded Ethosomal Vesicular Drug Delivery System for the Treatment of Melanoma Skin Cancer

Kollipara, Radha Krishna; Tallapaneni, Vyshnavi; Sanapalli, Bharat Kumar Reddy; G, Vinoth Kumar; Karri, Veera Venkata Satyanarayana Reddy

doi:10.5958/0974-360x.2019.00298.1

Cited by 18 publications

(11 citation statements)

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“…It is proven that the ethosome gel containing curcumin is a better formulation and requires studies in the future. In an ex vivo study, the result showed the curcumin-loaded ethosomal gel showed better treatment than in-house PTX gel in terms of drug deposition on the skin which was >60% in 12 h, whereas in-house PTX gel is shown the drug deposition was <60% in 12 h. In a nutshell, curcumin-loaded ethosomal gel allowed for the retention of curcumin in the deeper skin layers for a prolonged period, which helped completely eradicate the melanoma cells without inducing any painful sensation on the skin [103].…”

Section: Ethosomesmentioning

confidence: 95%

“…In the another study, Kollipara et al prepared curcumin-loaded ethosomes by using a hot method with a slight modification by employing probe sonication [103]. The different formulations' excipients demonstrated a different variation that affected the formulation characteristics in which the optimized curcumin-loaded ethosomes (F4) showed the zeta potential (−11.9 mV), with the smallest vesicle size (197.7 nm), as well as good polydispersity index (0.34).…”

Section: Ethosomesmentioning

confidence: 99%

“…Based on the studies discussed above, when PTX was loaded into ethosome, it was shown to prolong the drug releases to the target site to kill the cancer cell [98,103]. Moreover, there was a comparison between the curcumin-loaded ethosome and in-house PTX-loaded ethosome in these studies.…”

Section: Ethosomesmentioning

confidence: 99%

“…Moreover, ethosome displays as a highly efficient carrier to deliver the drug through the skin for the management of skin cancer [107]. For example, ethosomes act as a drug carrier for various therapeutic agents, such as 5-FU, PTX, mitoxantrone, berberine chloride, evodiamine, ferrous chlorophyll, fisetin, and curcumin [98][99][100][101][102][103][104]. Therefore, ethosome can be an efficient drug delivery in the treatment of skin cancer.…”

Section: Ethosomesmentioning

confidence: 99%

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Site-Specific Vesicular Drug Delivery System for Skin Cancer: A Novel Approach for Targeting

Pandey

Choudhury

Gorain

et al. 2021

Gels

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Skin cancer, one of the most prevalent cancers worldwide, has demonstrated an alarming increase in prevalence and mortality. Hence, it is a public health issue and a high burden of disease, contributing to the economic burden in its treatment. There are multiple treatment options available for skin cancer, ranging from chemotherapy to surgery. However, these conventional treatment modalities possess several limitations, urging the need for the development of an effective and safe treatment for skin cancer that could provide targeted drug delivery and site-specific tumor penetration and minimize unwanted systemic toxicity. Therefore, it is vital to understand the critical biological barriers involved in skin cancer therapeutics for the optimal development of the formulations. Various nanocarriers for targeted delivery of chemotherapeutic drugs have been developed and extensively studied to overcome the limitations faced by topical conventional dosage forms. A site-specific vesicular drug delivery system appears to be an attractive strategy in topical drug delivery for the treatment of skin malignancies. In this review, vesicular drug delivery systems, including liposomes, niosomes, ethosomes, and transfersomes in developing novel drug delivery for skin cancer therapeutics, are discussed. Firstly, the prevalence statistics, current treatments, and limitations of convention dosage form for skin cancer treatment are discussed. Then, the common type of nanocarriers involved in the research for skin cancer treatment are summarized. Lastly, the utilization of vesicular drug delivery systems in delivering chemotherapeutics is reviewed and discussed, along with their beneficial aspects over other nanocarriers, safety concerns, and clinical aspects against skin cancer treatment.

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Section: Ethosomesmentioning

confidence: 95%

Section: Ethosomesmentioning

confidence: 99%

Section: Ethosomesmentioning

confidence: 99%

Section: Ethosomesmentioning

confidence: 99%

See 2 more Smart Citations

Site-Specific Vesicular Drug Delivery System for Skin Cancer: A Novel Approach for Targeting

Pandey

Choudhury

Gorain

et al. 2021

Gels

View full text Add to dashboard Cite

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“…A controlled release of the lipophilic chemical curcumin was accomplished by loading it into the vesicles and then introducing it into the ethosomal gel. The ethosomal gel had good skin deposition, which allowed curcumin to stay in the skin's deeper layers for a longer duration of time, aiding in the full destruction of melanoma cells without inflicting significant discomfort to the skin (Krishna Kollipara et al, 2019).…”

Section: Therapeutic Potential Of Herbal Ethosomesmentioning

confidence: 99%

Ethosomes and their monotonous effects on Skin cancer disruption

Shinde

Page

Bhattacharya

2023

Front. Nanotechnol.

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Skin cancer is one of the most prominent diseases, affecting all continents worldwide, and has shown a significant rise in mortality and prevalence. Conventional therapy, including chemotherapy and surgery, has a few drawbacks. The ethosomal systems would be thoroughly reviewed in this compilation, and they would be classified based on constituents: classical ethosomes, binary ethosomes, and transethosomes. Ethosomes systems are model lipid vesicular carriers with a substantial portion of ethanol. The impacts of ethosomal system components, preparation techniques, and their major roles in selecting the final characteristics of these nanocarriers are comprehensively reviewed in this chapter. The special techniques for ethosomes, including the cold approach, hot approach, injection method, mechanical dispersion method, and conventional method, are explained in this chapter. Various evaluation parameters of ethosomes were also explained. Furthermore, ethosomal gels, patches, and creams can be emphasised as innovative pharmaceutical drug formulations. Some hybrid ethosomal vesicles possessing combinatorial cancer therapy using nanomedicine could overcome the current drug resistance of specific cancer cells. Through the use of repurpose therapy, phytoconstituents may be delivered more effectively. A wide range of in vivo models are employed to assess their effectiveness. Ethosomes have provided numerous potential skin cancer therapeutic approaches in the future.

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