Curcumin-loaded polysaccharide nanoparticles: Optimization and anticariogenic activity against Streptococcus mutans

Abstract

Curcumin was loaded into different polysaccharide nanoparticles chitosan, alginate and starch, using the desolvation method. Curcumin-loaded nanoparticles exhibited enhanced solubility in aqueous solutions comparing with free curcumin. Effects of formulation parameters such as curcumin concentration and different volumes of ethanolic solution were affected the particle size and loading efficiency. Under optimum conditions, curcumin-loaded chitosan, starch and alginate nanoparticles with mean particles sizes of 66.3, 61.1 and 78.8nm, and maximum loading efficiencies of 11.9%, 14.3% and 13.35% were achieved, respectively. Additionally, the minimum inhibitory concentration for chitosan, starch and alginate nanoparticles against the microorganism, Streptococcus mutans, were 0.114, 0.204 and 0.204mg/mL, respectively. Curcumin was observed to release from nanoparticles under physiological pH over a period of 96h. The effect of curcumin-loaded nanoparticles on S. mutans biofilms was assessed on dental models. According to the results, curcumin-loaded chitosan nanoparticles hold promises for being used in dental decay fighting products.

Curcumin-Loaded Starch Micro/Nano Particles for Biomedical Application: The Effects of Preparation Parameters on Release Profile

“…Besides this, some other improvements were obtained in our research. For example, %EEs achieved in our research were higher than %EE of curcumin‐loaded starch nanoparticles prepared by Maghsoudi et al The maximum %EE obtained by our experiments was 42.44 ± 0.2% which was much higher compared to their results (14.3%). This improvement in our research was due to the addition of pluronic F‐127 to the curcumin ethanolic solution used for drug loading in the starch micro/nano particles.…”

“…There are some reports in the literature on encapsulation of curcumin in the starch particles . However, none of them have examined the starch particles as drug carriers for osteosarcoma treatment.…”

Citric‐acid modified banana starch nanoparticles as a novel vehicle for β‐carotene delivery

“…Finally, Table shows the ξ ‐potential values of all the loaded and unloaded banana starch nanoparticles. As shown in Table , all the nanoparticles studied showed a slightly negative ξ ‐potential, a behavior that has been reported for other native and modified starch nanoparticles . Although no significant difference ( P > 0.05) exists between the loaded nanoparticles and their respective unloaded counterparts, the citric‐acid modified nanoparticles showed slightly lower ξ ‐potential values; this is probably due to the presence of the hydroxyl groups in the citric acid molecules, which are more easily hydrolyzable than those in the starch molecules.…”

“…As shown in Table 1, all the nanoparticles studied showed a slightly negative -potential, a behavior that has been reported for other native and modified starch nanoparticles. [38][39][40] Although no significant difference (P > 0.05) exists between the loaded nanoparticles and their respective unloaded counterparts, the citric-acid modified nanoparticles showed slightly lower -potential values; this is probably due to the presence of the hydroxyl groups in the citric acid molecules, which are more easily hydrolyzable than those in the starch molecules. All the nanoparticles studied showed -potential values greater than the generally accepted value for stable particle systems (−30 mV), indicating that the starch nanoparticle dispersions tend to precipitate rapidly.…”

Applications of nano-materials in diverse dentistry regimes

“…These ndings indicate that curcumin-loaded chitosan NPs could be applied in dental decay ghting products. 112 Covarrubias et al designed a study to develop hybrid NPs (CuCh NP) containing copper NPs with a chitosan shell. Antimicrobial features of CuCh NP have been evaluated against Streptococcus mutans, which is a major bacterium causing tooth decay and their activities could be compared to the oral antimicrobial agents, including cetylpyridinium chloride and chlorhexidine.…”