Curcumin-loaded redox-responsive mesoporous silica nanoparticles for targeted breast cancer therapy

Li, Nana; Wang, Zhi; Zhang, Yongtai; Zhang, Kai; Xie, Jianxu; Liu, Ying; Li, Wan-Si

doi:10.1080/21691401.2018.1473412

Cited by 53 publications

(38 citation statements)

References 42 publications

(49 reference statements)

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“…Similarly, in another study, Li et al developed MSN modified with PEI-FA (MSN-PEI-FA) and hyaluronic acid (MSN-HA) via disulphide bonds to achieve FA receptoror CD44-targeting. 101 Figure 6 Schematic representation comparing cytotoxic effect of (A) pure curcumin and (B) curcumin loaded MCM-41on SCC-25 cells. MCM-41-CUR was achieved via hydrogen-bond interaction and showed higher cytotoxicity.…”

Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

<p>Nano Encapsulated Curcumin: And Its Potential for Biomedical Applications</p>

Chen¹,

Lu²,

Lee³

et al. 2020

IJN

141

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Curcumin, a yellow-colored polyphenol extracted from the rhizome of turmeric root, is commonly used as a spice and nutritional supplement. It exhibits many pharmacological activities such as anti-inflammatory, anti-bacterial, anti-cancer, anti-Alzheimer, and anti-fungal. However, the therapeutic application of curcumin is limited by its extremely low solubility in aqueous buffer, instability in body fluids, and rapid metabolism. Nano delivery system has shown excellent potential to improve the solubility, biocompatibility and therapeutic effect of curcumin. In this review, we focus on the recent development of nano encapsulated curcumin and its potential for biomedical applications.

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Section: Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

<p>Nano Encapsulated Curcumin: And Its Potential for Biomedical Applications</p>

Chen¹,

Lu²,

Lee³

et al. 2020

IJN

141

View full text Add to dashboard Cite

show abstract

“…In this context, Li et al, have developed novel nanocarrier systems for tumor targeting and precise release of curcumin. These surface modifiable mesoporous silica nanomaterials have been exploited to deliver curcumin to breast cancer cell lines that were loaded with hyaluronan or polyethyleneimine-folic acid and were tested on mouse xenograft model [221]. The folic acid modified mesoporous silica nanomaterials showed an enhanced cellular uptake than hyaluronan mesoporous silica nanomaterials and both nanoformulations had better cellular uptake when compared with that of a non-targeted nanocarrier.…”

Section: Nanomaterials As Drug Delivery Agentsmentioning

confidence: 99%

Current trends and challenges in cancer management and therapy using designer nanomaterials

Navya¹,

et al. 2019

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Nanotechnology has the potential to circumvent several drawbacks of conventional therapeutic formulations. In fact, significant strides have been made towards the application of engineered nanomaterials for the treatment of cancer with high specificity, sensitivity and efficacy. Tailor-made nanomaterials functionalized with specific ligands can target cancer cells in a predictable manner and deliver encapsulated payloads effectively. Moreover, nanomaterials can also be designed for increased drug loading, improved half-life in the body, controlled release, and selective distribution by modifying their composition, size, morphology, and surface chemistry. To date, polymeric nanomaterials, metallic nanoparticles, carbon-based materials, liposomes, and dendrimers have been developed as smart drug delivery systems for cancer treatment, demonstrating enhanced pharmacokinetic and pharmacodynamic profiles over conventional formulations due to their nanoscale size and unique physicochemical characteristics. The data present in the literature suggest that nanotechnology will provide next-generation platforms for cancer management and anticancer therapy. Therefore, in this critical review, we summarize a range of nanomaterials which are currently being employed for anticancer therapies and discuss the fundamental role of their physicochemical properties in cancer management. We further elaborate on the topical progress made to date toward nanomaterial engineering for cancer therapy, including current strategies for drug targeting and release for efficient cancer administration. We also discuss issues of nanotoxicity, which is an often-neglected feature of nanotechnology. Finally, we attempt to summarize the current challenges in nanotherapeutics and provide an outlook on the future of this important field.

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“…This process led to exclusion of 50 articles according to exclusion criteria (Table S2). In the end, 26 articles were maintained and included in this systematic review (Table 1) (25)(26)(27)(28)(29)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50). A flowchart detailing this process is shown in Figure 3.…”

Section: Study Selectionmentioning

confidence: 99%

“…Similarly, attachment of HA, a natural polysaccharide consisting of repeating disaccharide units, to the surface of NPs, has been investigated since it binds to the cell surface molecule CD44, a surface protein widely expressed in breast cancer (68). Curcumin associated with HA-mesoporous silica NPs showed a significant~70% reduction in tumor weight, while no significant effect was observed for free curcumin (39). Other modifications of the curcumin-NP surface with ligands TABLE 3 | Risk of bias in individual studies (SYRCLE's Rob toll criteria).…”

Section: Summary Of Evidencementioning

confidence: 99%

In Vivo Efficacy and Toxicity of Curcumin Nanoparticles in Breast Cancer Treatment: A Systematic Review

et al. 2021

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Breast cancer is one of the most prevalent types of malignant tumors in the world, resulting in a high incidence of death. The development of new molecules and technologies aiming to apply more effective and safer therapy strategies has been intensively explored to overcome this situation. The association of nanoparticles with known antitumor compounds (including plant-derived molecules such as curcumin) has been considered an effective approach to enhance tumor growth suppression and reduce adverse effects. Therefore, the objective of this systematic review was to summarize published data regarding evaluations about efficacy and toxicity of curcumin nanoparticles (Cur-NPs) in in vivo models of breast cancer. The search was carried out in the databases: CINAHL, Cochrane, LILACS, Embase, FSTA, MEDLINE, ProQuest, BSV regional portal, PubMed, ScienceDirect, Scopus, and Web of Science. Studies that evaluated tumor growth in in vivo models of breast cancer and showed outcomes related to Cur-NP treatment (without association with other antitumor molecules) were included. Of the 528 initially gathered studies, 26 met the inclusion criteria. These studies showed that a wide variety of NP platforms have been used to deliver curcumin (e.g., micelles, polymeric, lipid-based, metallic). Attachment of poly(ethylene glycol) chains (PEG) and active targeting moieties were also evaluated. Cur-NPs significantly reduced tumor volume/weight, inhibited cancer cell proliferation, and increased tumor apoptosis and necrosis. Decreases in cancer stem cell population and angiogenesis were also reported. All the studies that evaluated toxicity considered Cur-NP treatment to be safe regarding hematological/biochemical markers, damage to major organs, and/or weight loss. These effects were observed in different in vivo models of breast cancer (e.g., estrogen receptor-positive, triple-negative, chemically induced) showing better outcomes when compared to treatments with free curcumin or negative controls. This systematic review supports the proposal that Cur-NP is an effective and safe therapeutic approach in in vivo models of breast cancer, reinforcing the currently available evidence that it should be further analyzed in clinical trials for breast cancer treatments.

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Curcumin-loaded redox-responsive mesoporous silica nanoparticles for targeted breast cancer therapy

Cited by 53 publications

References 42 publications

<p>Nano Encapsulated Curcumin: And Its Potential for Biomedical Applications</p>

<p>Nano Encapsulated Curcumin: And Its Potential for Biomedical Applications</p>

Current trends and challenges in cancer management and therapy using designer nanomaterials

In Vivo Efficacy and Toxicity of Curcumin Nanoparticles in Breast Cancer Treatment: A Systematic Review

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