Curcumin May Prevent Basement Membrane Disassembly by Matrix Metalloproteinases and Progression of the Bladder Cancer

Abstract

Authors present a review of crucial mechanisms contributing to the invasion of the basement membrane (BM) of the urothelium by cancer cells and to the progression of bladder cancer (BC). The breeching of the urothelial BM, facilitated by an aberrant activation of matrix metalloproteinases (MMP) is particularly perilous. Inhibition of activation of these proteinases constitutes a logic opportunity to restrain progression. Because of limited efficacy of current therapeutic methods, the search for the development of alternative approaches constitutes “the hot spot” of modern oncology. Recent studies revealed significant anticancer potential of natural phytochemicals. Especially, curcumin has emerged as a one of the most promising phytochemicals and showed its efficacy in several human malignancies. Therefore, this article addresses experimental and clinical data indicating multi-directional inhibitory effect of curcumin on the growth of bladder cancer. We particularly concentrate on the mechanisms, by which curcumin inhibits the MMP’s activities, thereby securing BM integrity and alleviating the eventual cancer invasion into the bladder muscles. Authors review the recently accumulating data, that curcumin constitutes a potent factor contributing to the more effective treatment of the bladder cancer.

Construction of endothelial cell signatures for predicting the diagnosis, prognosis and immunotherapy response of bladder cancer via machine learning

“…Doxorubicin, an important component of combination therapy for muscle‐invasive BC, interferes with cell cycle progression and leads to cancer cell death 49 . Curcumin has a wide range of anticancer activities; it can inhibit the proliferation of BC cells, induce the apoptosis of BC cells, prevent the metastasis of BC cells, promote the antitumor immune response, and enhance the effect of chemotherapeutic drugs when used in combination with chemical drugs 50–52 . However, curcumin has the disadvantage of low bioavailability, and the development of curcumin nanoparticles may significantly improve this problem 53 .…”

“…49 Curcumin has a wide range of anticancer activities; it can inhibit the proliferation of BC cells, induce the apoptosis of BC cells, prevent the metastasis of BC cells, promote the antitumor immune response, and enhance the effect of chemotherapeutic drugs when used in combination with chemical drugs. [50][51][52] However, curcumin has the disadvantage of low bioavailability, and the development of curcumin nanoparticles may significantly improve this problem. 53 We found that the mRNA levels of CYP1B1 were reduced after curcumin treatment.…”

Prognostic significance and identification of basement membrane-associated lncRNA in bladder cancer

“…Loss of laminin 5 expression in immunohistochemistry is strongly associated with increased BCa mortality ( 27 ). Highly aggressive tumors secrete laminin and collagen IV, and overexpression of these two proteins promotes tumor growth and angiogenesis ( 28 ). The usefulness of BM detection for the classified staging of BCa has also reached widespread recognition ( 25 ).…”

The anticancer effects of curcumin and clinical research progress on its effects on esophageal cancer

“…In addition, curcumin enhanced the expression of nonmetastatic gene 23 (Nm23), antimetastatic protein tissue inhibitor metalloproteinase (TIMP)-2, and E-cadherin, which inhibited the migration of tumor cells. In addition, Wroński et al (2021) revealed a mechanism of bladder cancer progression, in which cancer cells activated matrix metalloproteinases (MMPs) and invaded the urothelial basement membrane. Curcumin can inhibit the aberrant activation of MMPs and maintain the integrity of the basement membrane, thus suppressing eventual cancer invasion into the bladder.…”