Curcumin nanoemulsion for transdermal application: formulation and evaluation

Abstract

The aim of this work is to develop a curcumin nanoemulsion for transdermal delivery. The incorporation of curcumin inside a nanoglobul should improve curcumin stability and permeability. A nanoemulsion was prepared by the self-nanoemulsification method, using an oil phase of glyceryl monooleate, Cremophor RH40 and polyethylene glycol 400. Evaluation of the nanoemulsion included analysis of particle size, polydispersity index, zeta potential, physical stability, Raman spectrum and morphology. In addition, the physical performance of the nanoemulsion in Viscolam AT 100P gel was studied. A modified vertical diffusion cell and shed snake skin of Python reticulatus were used to study the in vitro permeation of curcumin. A spontaneously formed stable nanoemulsion has a loading capacity of 350 mg curcumin/10 g of oil phase. The mean droplet diameter, polydispersity index and zeta potential of optimized nanoemulsion were 85.0 ± 1.5 nm, 0.18 ± 0.0 and -5.9 ± 0.3 mV, respectively. Curcumin in a nanoemulsion was more stable than unencapsulated curcumin. Furthermore, nanoemulsification significantly improved the permeation flux of curcumin from the hydrophilic matrix gel; the release kinetic of curcumin changed from zero order to a Higuchi release profile. Overall, the developed nanoemulsion system not only improved curcumin permeability but also protected the curcumin from chemical degradation.

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

“…This also came in accordance with several other authors (Lucas-Abellán et al, 2007;Caddeo et al, 2008;Coimbra et al, 2011;Sessa et al, 2014), who declared that encapsulation of resveratrol in carriers, such as cyclodextrin complexes, liposomes and lecithin-based nanoemulsions were able to improve the stability of resveratrol. Similarly, this could be applied to curcumin, in which authors reported that its encapsulation in nanoformulations improves its stability (Rachmawati et al, 2015). The fact that the prepared nanoemulsion was able to maintain the concentration of the two polyphenols with no degradation, and preserve their antioxidant activity, proves that nanoemulsions provide an inert environment for both polyphenolic drugs.…”

Nanoemulsion Based Palm Olein as Vitamin E Carrier

“…In the recent years, nanoemulsion has gain interest as a colloidal delivery system within the food, pharmaceuticals, cosmeceuticals, and other industries to encapsulate, protect and deliver bioactive lipophilic components, such as drugs, vitamins, neutraceuticals and antioxidants [5][6][7]. Nanoemulsion is defined as emulsion system having particle size ranging from 20 -500 nm [8,9].…”

“…Basically, nanoemulsion can be prepared using two methods: the high energy method that involves the use of mechanical devices (e.g. ultrasonicator, rotor/stator system and high pressure homogenizer) and low energy method in which the chemical potential of the component is used such as phase inversion temperature (PIT), phase inversion composition (PIC) and spontaneous emulsification method [6][7]10].…”

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

“…166 Similarly curcumin nanoemulsions were developed using a self-nanoemulsifying method with the mean particle size of 85 nm and showed enhanced transdermal availability with high permeability and without degradation. 71 This might be useful in the skin care sectors for developing novel skin cream emulsions. In another study, lutein was successfully encapsulated into nanoemulsions in the size range of 150-350 nm and increased the release of the active compound compared to other lipid carriers.…”

“…The aforementioned products prevent skin aging due to oxidative stress and premature aging. [69][70][71][72][73] The combination of polyphenols with retinols enhances skin protection. Other than nanosizing, few delivery systems have been used to develop nanoantiaging creams and lotions for the enhanced activity of bioactive compounds to deeper layers of skin.…”