Curcumin-p-sulfonatocalix[4]resorcinarene (p-SC[4]R) interaction: thermo-physico chemistry, stability and biological evaluation

Abstract

The new 1:1 stoichiometry complex formation of curcumin-p-SC[4]R has been investigated with the aim to enhance the solubility, bioavailability, stability and anti-oxidant activity as well as decreased in vivo acute oral toxicity of curcumin by inclusion complexation. Thermodynamic parameters ∆S and ∆H are a negative value indicates that the inclusion complex was an exothermic process which occurred spontaneously. The inclusion complex was characterised by different analytical methods including FT-IR, PXRD, 1 H-NMR, SEM, DSC, ESI-Mass, UV-Vis spectroscopy and Elemental analysis.

An innovative extraction strategy for herbal medicine by adopting p‐sulphonatocalix[6]/[8]arenes

“…The typical bands at 2834 cm −1 , 2931 cm −1 were assigned to C–H stretching and weak peaks at 1022 cm −1 , 1220–1280 cm −1 were corresponded to C–O–C stretching vibration 33,34 . SC6A/SC8A exhibited a broad absorption around 3416 cm −1 for O–H group stretching vibration and a sharp peak around 1030–1180 cm −1 mainly arising from –SO 3 group 35,36 . The FTIR spectra of the physical mixture also retained the characteristic bands of tetrandrine and SC6A/SC8A with slight shifts, which suggested that no complexation occurred in the process of physical mixing.…”

“…33,34 SC6A/SC8A exhibited a broad absorption around 3416 cm À1 for O-H group stretching vibration and a sharp peak around 1030-1180 cm À1 mainly arising from -SO 3 group. 35,36 The FTIR spectra of the physical mixture also retained the characteristic bands of tetrandrine and SC6A/SC8A with slight shifts, which suggested that no complexation occurred in the process of physical mixing. However, the vibration peak at 2931 cm À1 , 2834 cm À1 and 1220-1280 cm À1 of tetrandrine disappeared in tetrandrine-SCnA complex, which may be due to the electrostatic interaction between the positively charged aromatic amines of tetrandrine and the negatively charged sulphonic group of SC6A/ SC8A, indicating a new structure formed between tetrandrine and SCnA.…”

Antibacterial Host–Guest Intercalated LDH-Adorned Polyurethane for Accelerated Dermal Wound Healing

“…NMR spectroscopy was used to clarify the encapsulation of guest drug molecules into different types of macrocycle cavities. Figure d shows the 13 C NMR spectra of curcumin, SC4A, the curcumin and SC4A physical mixture, and the Cur-SC4A inclusion complex . The successful inclusion of guest curcumin inside SC4A cavities is confirmed by the observable changes in peak shifts and intensities compared to the curcumin and SC4A physical mixture’s characteristic peaks.…”

An eco‐friendly extraction and purification method of nuciferine from Folium nelumbinis with p‐sulfonatocalix[6]arenes

“…Weak bands at 2,952 cm −1 and 2,839 cm −1 were due to C–H stretching and sharp peaks at 1,138 cm −1 and 1,104 cm −1 were assigned to C–O stretching (Figure 6). For SC6A, the broad band at 3,382 cm −1 for O–H group stretching vibration and the characteristic peaks at 1,165 cm −1 and 1,040 cm −1 represented the stretching vibration of the –SO 3 group 31,32 . The mixture powder exhibited a combination of the main absorption bands of nuciferine and SC6A, indicating that no complexation occurred in the process of physical mixing.…”