Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

Wang, Hao; Sui, Hai-juan; Zheng, Yan; Jiang, Yibing; Shi, Yijie; Liang, Jia; Zhao, Liang

doi:10.1039/c9nr01255a

Cited by 245 publications

(174 citation statements)

References 45 publications

Supporting

Mentioning

172

Contrasting

Unclassified

Order By: Relevance

“…Curcumin encapsulated in exosomes crosses the BBB and reaches the neuronal tissue where it inhibits the hyperphosphorylation of Tau proteins, thus reducing the symptoms of Alzheimer's disease. This mechanism is explained by the activation of the AKT/GSK-3β pathway [143].…”

Section: Nanoformulation: Molecules Extraction Techniques and Alzheimentioning

confidence: 99%

See 1 more Smart Citation

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Salehi

Calina

Docea

et al. 2020

JCM

138

View full text Add to dashboard Cite

The brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β-binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.

show abstract

Section: Nanoformulation: Molecules Extraction Techniques and Alzheimentioning

confidence: 99%

“…hyperphosphorylation of Tau proteins, thus reducing the symptoms of Alzheimer's disease. This mechanism is explained by the activation of the AKT/GSK-3β pathway [143]. Magnetic CUR nanoparticles can be used in neurodegenerative disorders under the influence of external magnetic fields [144].…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Salehi

Calina

Docea

et al. 2020

JCM

138

View full text Add to dashboard Cite

show abstract

“…[ 25 ] For example, one report illustrated that exosomes loaded with curcumin effectively improved cognitive function in C57BL/6 mice inducing AD model in vivo. [ 26 ] In another study, Xue and his colleagues used neutrophils as carrier, which showed significant improvement in BBB‐traversing ability. [ 27 ] Receptor‐mediated transcytosis (RMT) is the most commonly used strategy to enable chemotherapeutics to cross the BBB.…”

Section: Nps For Drug Delivery Into the Brain: Role And Advantagesmentioning

confidence: 99%

Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics

Mukherjee

Madamsetty

Bhattacharya

et al. 2020

Adv Funct Materials

107

View full text Add to dashboard Cite

Recent times have witnessed an upsurge in the incidence of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Prion disease, and amyotrophic lateral sclerosis. The treatment of the same remains a daunting challenge due to the limited access of therapeutic moieties across the blood–brain barrier. Engineered nanoparticles with a size less than 100 nm provide multifunctional abilities for solving these biomedical and pharmacological issues due to their unique physico‐chemical properties along with capability to cross the blood–brain barrier. Needless to mention, there is a scarcity of review articles summarizing recent developments of various nanomaterials including liposomes, polymeric nanoparticles, metal nanoparticles, and bio‐nanoparticles toward the therapeutic and theranostics applications for various neurodegenerative disorders. Here, a broad spectrum of nanomedicinal approaches to eradicate neurodegenerative disorders is provided, along with a brief account of neuroprotection and neuronal tissue regeneration, current clinical status, issues related to safety, toxicity, challenges, and future outlook.

show abstract

“…Recently, neuroinflammation induced by proinflammatory cytokines was suggested as a novel pathogenesis of ASD, particularly in irritability and socialization problems [275]. As a therapeutic approach, stem-cell-derived exosomes containing anti-inflammatory molecules could be used as efficient carriers for delivering anti-inflammatory molecules across the blood-brain barrier [276]. These attempts have already been made to alleviate the symptoms of Alzheimer's disease [276].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…As a therapeutic approach, stem-cell-derived exosomes containing anti-inflammatory molecules could be used as efficient carriers for delivering anti-inflammatory molecules across the blood-brain barrier [276]. These attempts have already been made to alleviate the symptoms of Alzheimer's disease [276].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Genetic and Epigenetic Etiology Underlying Autism Spectrum Disorder

Yoon

Choi

Lee

et al. 2020

JCM

105

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized by difficulties in social interaction, language development delays, repeated body movements, and markedly deteriorated activities and interests. Environmental factors, such as viral infection, parental age, and zinc deficiency, can be plausible contributors to ASD susceptibility. As ASD is highly heritable, genetic risk factors involved in neurodevelopment, neural communication, and social interaction provide important clues in explaining the etiology of ASD. Accumulated evidence also shows an important role of epigenetic factors, such as DNA methylation, histone modification, and noncoding RNA, in ASD etiology. In this review, we compiled the research published to date and described the genetic and epigenetic epidemiology together with environmental risk factors underlying the etiology of the different phenotypes of ASD.

show abstract

Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

Abstract: Curcumin-primed exosomes (Exo-Cur) can better relieve the symptoms of AD by inhibiting phosphorylation of Tau protein through AKT/GSK-3β pathway.

Cited by 245 publications

References 45 publications

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics

Genetic and Epigenetic Etiology Underlying Autism Spectrum Disorder

Contact Info

Product

Resources

About