Curcumin protects against acoustic trauma in the rat cochlea

Soyalıç, Harun; Gevrek, Fıkret; Karaman, Serhat

doi:10.1016/j.ijporl.2017.05.029

Cited by 19 publications

(8 citation statements)

References 22 publications

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“…However, CCM was principally effective in maintaining the hearing function, reflected by a significant improvement in DOPAE at most tested frequencies even with GEN or NaS administration. Similar findings were previously recorded in the studies of Soyalıç et al ( 2016 ) and Soyalıç et al ( 2017 ). In this regard, CCM has been identified as vasodilatory and used to lower blood pressure, benefitting blood circulation to Corti’s organ (Nugroho et al 2008 ).…”

Section: Discussionsupporting

confidence: 92%

“…The CCM otoprotective ability may be closely related to its potent antioxidant and antiapoptotic activities. Correspondingly, CCM usage decreased cellular apoptosis and had a profound safety effect on auditory function in an acoustic trauma rat model (Soyalıç et al 2017 ). CCM also stopped caspase-3 activation, modifying the expression of the Bcl-2 family in spiral ganglion neurons activated by peroxynitrite (Liu et al 2011 ).…”

Section: Discussionmentioning

confidence: 99%

“…Also, CCM has strong anti-inflammatory (Aggarwal and Harikumar 2009 ), antiapoptotic (Abd-Elhakim et al 2021b ), antigenotoxic (Saber et al 2019 ), and immunostimulant (Mollazadeh et al 2019 ) activities. Besides, CCM has shown important protective effects against widespread ototoxic substances and hearing disorders (Bucak et al 2015 ; Soyalıç et al 2017 ; Soyalıç et al 2016 ). In addition, CCM protected cochlear fibroblasts from diabetes-related oxidative damage in rat models (Haryuna et al 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Curcumin attenuates gentamicin and sodium salicylate ototoxic effects by modulating the nuclear factor-kappaB and apoptotic pathways in rats

Abd‐Elhakim

Abdel-Motal

Malhat³

et al. 2022

Environ Sci Pollut Res

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This study aimed to investigate the effectiveness of curcumin (CCM) against gentamicin (GEN) and sodium salicylates (NaS)-induced ototoxic effects in rats. For 15 consecutive days, seven rat groups were given 1 mL/rat physiological saline orally, 1 mL/rat olive oil orally, 50 mg/kg bwt CCM orally, 120 mg/kg bwt GEN intraperitoneally, 300 mg/kg bwt NaS intraperitoneally, CCM+GEN, or CCM+NaS. The distortion product otoacoustic emission measurements were conducted. The rats’ hearing function and balance have been behaviorally assessed using auditory startle response, Preyer reflex, and beam balance scale tests. The serum lipid peroxidation and oxidative stress biomarkers have been measured. Immunohistochemical investigations of the apoptotic marker caspase-3 and the inflammatory indicator nuclear factor kappa (NF-κB) in cochlear tissues were conducted. GEN and NaS exposure resulted in deficit hearing and impaired ability to retain balance. GEN and NaS exposure significantly decreased the reduced glutathione level and catalase activity but increased malondialdehyde content. GEN and NaS exposure evoked pathological alterations in cochlear and vestibular tissues and increased caspase-3 and NF-κB immunoexpression. CCM significantly counteracted the GEN and NaS injurious effects. These outcomes concluded that CCM could be a naturally efficient therapeutic agent against GEN and NaS-associated ototoxic side effects. Graphical abstract

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Curcumin attenuates gentamicin and sodium salicylate ototoxic effects by modulating the nuclear factor-kappaB and apoptotic pathways in rats

Abd‐Elhakim

Abdel-Motal

Malhat³

et al. 2022

Environ Sci Pollut Res

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“…We subjected the powder through processing procedures as we described in our previously published article. [22] Briefly, 2.5 g dry curcumin powder (Sigma-Aldrich) was placed in successive dilutions of dimethylsulfoxide (DMSO), and ethanol, and dissolved with the aid of magnetic mixer under room temperature. Priorly, DMSO curcumin solution was centrifuged at 5000 rpm for 10 min- utes.…”

Section: Preparation Of Curcumin Extract Solutionmentioning

confidence: 99%

Investigation of the effects of curcumin, vitamin E and their combination in cisplatin-induced testicular apoptosis using immunohistochemical technique

Gevrek

Erdemır

2018

Turkish Journal of Urology

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“…Five slides from each group were used to count apoptotic cells. The apoptotic index was evaluated as a percentage of the apoptotic and control cells (Soyalıç, Gevrek, & Karaman, ; Soyalıç et al., ).…”

Section: Methodsmentioning

confidence: 99%

The ameliorative effects ofGinkgo bilobaon apoptosis, LH-R expression and sperm morphology anomaly in testicular torsion and detorsion

et al. 2018

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Torsion/detorsion (T/D) induces testicular damages in both germinal epithelial and interstitial tissues. Ginkgo biloba extract (GbE) exerts antioxidant and free radical scavenger. We investigated the effect of GbE on testicular tissues, Leydig and sperm cells in rats injured with T/D. Twenty-eight Wistar albino rats were randomly assigned into four groups (Control, GbE, Treatment: T/D+GbE, T/D). T/D performed to the rats in torsion, treatment received GbE (50 mg/kg) 1 hr before T/D, GbE group received only GbE (50 mg/kg) and control was defined as sham group. After T/D, the testes along with epididymis were removed and processed. LH-R expression, apoptosis, sperm morphology and histopathological damage scores were determined for each group. Testicular T/D caused significant increases in apoptosis and sperm morphology anomaly, and a significant decrease in Johnsen's testicular biopsy scores, LH-R expression of Leydig cell and normal sperm cell count. GbE ameliorated testicular histopathology and caused significant increases in LH-R expression, normal sperm cell count in the treated and particularly GbE group. Consequently, GbE may prevent testicular injury and enhance Leydig and sperm cell activity following both T/D and normal situation owing to its antioxidant, anti-apoptotic, free radical scavenger and anti-inflammatory effects.

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Curcumin protects against acoustic trauma in the rat cochlea

Cited by 19 publications

References 22 publications

Curcumin attenuates gentamicin and sodium salicylate ototoxic effects by modulating the nuclear factor-kappaB and apoptotic pathways in rats

Curcumin attenuates gentamicin and sodium salicylate ototoxic effects by modulating the nuclear factor-kappaB and apoptotic pathways in rats

Investigation of the effects of curcumin, vitamin E and their combination in cisplatin-induced testicular apoptosis using immunohistochemical technique

The ameliorative effects ofGinkgo bilobaon apoptosis, LH-R expression and sperm morphology anomaly in testicular torsion and detorsion

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